MeSH term
Frequency | Condition_Probility | Adult | 2 | 0.0 |
Humans | 110 | 0.0 |
Male | 9 | 0.0 |
Middle Aged | 2 | 0.0 |
1-Phosphatidylinositol 3-Kinase/*metabolism | 11 | 4.0 |
Animals | 70 | 0.0 |
Cell Line | 36 | 0.0 |
Cell Line, Tumor | 4 | 0.0 |
Enzyme Activation | 39 | 1.0 |
Hydrophobicity | 4 | 5.0 |
Immunoprecipitation | 3 | 1.0 |
Phosphorylation | 74 | 0.0 |
Protein Kinases/*metabolism | 3 | 0.0 |
Protein-Serine-Threonine Kinases/*metabolism | 26 | 3.0 |
Proteins/metabolism | 3 | 0.0 |
Proto-Oncogene Proteins/*metabolism | 15 | 1.0 |
Research Support, Non-U.S. Gov't | 82 | 0.0 |
Research Support, U.S. Gov't, P.H.S. | 32 | 0.0 |
Serine/metabolism | 10 | 3.0 |
Amino Acid Sequence | 36 | 0.0 |
Binding Sites | 25 | 0.0 |
Comparative Study | 4 | 0.0 |
Crystallography, X-Ray | 2 | 0.0 |
Glutathione Transferase/metabolism | 5 | 0.0 |
Lipids/metabolism | 2 | 0.0 |
Models, Molecular | 6 | 0.0 |
Mutagenesis, Site-Directed | 9 | 0.0 |
Mutation | 13 | 0.0 |
Protein Structure, Tertiary | 18 | 0.0 |
Protein-Serine-Threonine Kinases/*chemistry/genetics/*metabolism | 5 | 33.0 |
Recombinant Fusion Proteins/metabolism | 3 | 0.0 |
Cell Transformation, Neoplastic/*metabolism | 2 | 5.0 |
Female | 6 | 0.0 |
Mice | 32 | 0.0 |
Mice, Inbred BALB C | 4 | 0.0 |
Research Support, U.S. Gov't, Non-P.H.S. | 7 | 0.0 |
Signal Transduction/physiology | 3 | 0.0 |
Tumor Cells, Cultured | 10 | 0.0 |
Apoptosis/*drug effects | 2 | 0.0 |
Dose-Response Relationship, Drug | 8 | 0.0 |
Kinetics | 8 | 0.0 |
Phosphoserine/metabolism | 3 | 3.0 |
Phosphothreonine/metabolism | 3 | 7.0 |
Protein-Serine-Threonine Kinases/*antagonists & inhibitors | 3 | 6.0 |
Androstadienes/pharmacology | 9 | 3.0 |
DNA-Binding Proteins/*metabolism | 2 | 0.0 |
Enzyme Inhibitors/pharmacology | 15 | 0.0 |
Flavonoids/pharmacology | 3 | 0.0 |
Glycogen Synthase Kinase 3 | 5 | 5.0 |
Sirolimus/pharmacology | 5 | 6.0 |
Transcription Factors/*metabolism | 3 | 0.0 |
Cell Division | 7 | 0.0 |
Chromatography, Gel | 3 | 0.0 |
Electrophoresis, Polyacrylamide Gel | 3 | 0.0 |
Plasmids/metabolism | 6 | 0.0 |
Protein Binding | 24 | 0.0 |
Protein Kinases/*chemistry | 2 | 20.0 |
Time Factors | 10 | 0.0 |
Cells, Cultured | 11 | 0.0 |
DNA-Binding Proteins/metabolism | 2 | 0.0 |
*Nuclear Proteins | 9 | 0.0 |
Signal Transduction/drug effects/physiology | 2 | 0.0 |
Transcription Factors/metabolism | 4 | 0.0 |
Cell Membrane/metabolism | 3 | 0.0 |
Gene Deletion | 2 | 0.0 |
Jurkat Cells | 3 | 0.0 |
Microscopy, Confocal | 4 | 0.0 |
Phosphorylation/drug effects | 6 | 0.0 |
Protein Kinase C/*metabolism | 5 | 1.0 |
Protein Transport | 2 | 0.0 |
Protein-Serine-Threonine Kinases/metabolism | 13 | 1.0 |
Signal Transduction | 21 | 0.0 |
1-Phosphatidylinositol 3-Kinase/antagonists & inhibitors/*metabolism | 3 | 4.0 |
Cell Division/physiology | 2 | 0.0 |
Chromones/pharmacology | 4 | 1.0 |
Morpholines/pharmacology | 4 | 1.0 |
1-Phosphatidylinositol 3-Kinase/metabolism | 13 | 2.0 |
Antineoplastic Agents/*pharmacology | 4 | 0.0 |
Apoptosis/drug effects | 2 | 0.0 |
Caspases/metabolism | 2 | 0.0 |
Enzyme Activation/drug effects | 6 | 0.0 |
Enzyme Inhibitors/*pharmacology | 2 | 0.0 |
Molecular Sequence Data | 34 | 0.0 |
Staurosporine/analogs & derivatives | 2 | 8.0 |
COS Cells | 8 | 0.0 |
Cell Line, Transformed | 5 | 0.0 |
Cercopithecus aethiops | 2 | 0.0 |
Peptides | 2 | 3.0 |
Proto-Oncogene Proteins/metabolism | 12 | 1.0 |
Recombinant Fusion Proteins/genetics/metabolism | 5 | 0.0 |
Acetylation | 2 | 0.0 |
Gene Expression Regulation, Enzymologic | 4 | 0.0 |
Isoenzymes/*metabolism | 6 | 2.0 |
Oxidation-Reduction | 2 | 0.0 |
Substrate Specificity | 16 | 0.0 |
Apoptosis | 4 | 0.0 |
Cell Survival | 2 | 0.0 |
DNA, Complementary/metabolism | 5 | 0.0 |
Two-Hybrid System Techniques | 3 | 0.0 |
Blotting, Western | 9 | 0.0 |
Cysteine Endopeptidases/metabolism | 2 | 0.0 |
Down-Regulation | 4 | 0.0 |
Multienzyme Complexes/metabolism | 2 | 1.0 |
Precipitin Tests | 10 | 0.0 |
Proteasome Endopeptidase Complex | 2 | 0.0 |
Protein Conformation | 6 | 0.0 |
*Signal Transduction | 10 | 0.0 |
Transfection | 20 | 0.0 |
Enzyme Activation/physiology | 3 | 1.0 |
Amino Acid Motifs | 6 | 0.0 |
Catalytic Domain | 4 | 1.0 |
In Vitro | 7 | 0.0 |
Phylogeny | 2 | 0.0 |
Protein Kinases/*chemistry/genetics/*metabolism | 2 | 40.0 |
Signal Transduction/*physiology | 4 | 0.0 |
Temperature | 3 | 0.0 |
Microscopy, Fluorescence | 4 | 0.0 |
Mitogen-Activated Protein Kinases/metabolism | 4 | 0.0 |
Models, Biological | 11 | 0.0 |
Myristic Acids/metabolism | 2 | 14.0 |
Cell Survival/drug effects | 2 | 0.0 |
Insulin-Like Growth Factor I/pharmacology | 5 | 2.0 |
Phosphatidylinositol Phosphates/metabolism | 5 | 10.0 |
Recombinant Proteins/metabolism | 8 | 0.0 |
Serine/*metabolism | 3 | 3.0 |
Threonine/*metabolism | 3 | 7.0 |
Carrier Proteins/metabolism | 4 | 0.0 |
Phosphoproteins/metabolism | 4 | 0.0 |
Ribosomal Protein S6 Kinases/*metabolism | 3 | 12.0 |
*Ribosomal Protein S6 Kinases, 90-kDa | 2 | 20.0 |
Pyruvate Dehydrogenase Complex/*metabolism | 3 | 16.0 |
Adenosine Triphosphate/metabolism | 4 | 0.0 |
Mitochondria/enzymology | 2 | 1.0 |
Protein Isoforms | 4 | 0.0 |
Sequence Homology, Amino Acid | 16 | 0.0 |
Vanadates/pharmacology | 4 | 2.0 |
src-Family Kinases/metabolism | 3 | 1.0 |
Ca(2+)-Calmodulin Dependent Protein Kinase/metabolism | 4 | 1.0 |
Glycogen Synthase Kinases | 3 | 5.0 |
Insulin/physiology | 3 | 9.0 |
Peptides/metabolism | 2 | 0.0 |
*Protein-Serine-Threonine Kinases | 13 | 1.0 |
*Signal Transduction/drug effects | 2 | 2.0 |
*Proto-Oncogene Proteins | 8 | 0.0 |
Imidazoles/pharmacology | 2 | 0.0 |
Mice, Knockout | 4 | 0.0 |
Mitogen-Activated Protein Kinase 1/metabolism | 2 | 0.0 |
Protein Subunits | 2 | 0.0 |
Pyridines/pharmacology | 2 | 0.0 |
p38 Mitogen-Activated Protein Kinases | 3 | 0.0 |
3T3 Cells | 5 | 0.0 |
Cell Division/*drug effects | 2 | 0.0 |
Signal Transduction/*drug effects | 3 | 0.0 |
Proto-Oncogene Proteins/antagonists & inhibitors/*metabolism | 2 | 7.0 |
Rats | 10 | 0.0 |
Ribosomal Protein S6 Kinases/metabolism | 4 | 5.0 |
Tetradecanoylphorbol Acetate/pharmacology | 3 | 0.0 |
Alleles | 3 | 0.0 |
Enzyme-Linked Immunosorbent Assay | 3 | 0.0 |
Hela Cells | 2 | 0.0 |
Immunoblotting | 6 | 0.0 |
Immunohistochemistry | 3 | 0.0 |
Isoenzymes/metabolism | 3 | 0.0 |
Trans-Activation (Genetics) | 2 | 0.0 |
Protein-Serine-Threonine Kinases/*genetics/metabolism | 2 | 3.0 |
Sequence Analysis, DNA | 2 | 0.0 |
Phosphatidylinositols/metabolism | 2 | 1.0 |
Protein Kinase C/chemistry/*metabolism | 2 | 18.0 |
Mitogen-Activated Protein Kinase Kinases/metabolism | 2 | 1.0 |
Mitogen-Activated Protein Kinases/*metabolism | 5 | 0.0 |
Protein-Tyrosine Kinase/metabolism | 4 | 0.0 |
Structure-Activity Relationship | 3 | 0.0 |
3T3-L1 Cells | 2 | 8.0 |
Insulin/metabolism | 2 | 1.0 |
Recombinant Proteins/chemistry/metabolism | 2 | 0.0 |
Serine/chemistry | 3 | 2.0 |
Peptides/chemistry | 3 | 0.0 |
Protein Kinase C/metabolism | 3 | 0.0 |
Insulin/pharmacology | 3 | 1.0 |
Protein-Serine-Threonine Kinases/genetics/*metabolism | 7 | 2.0 |
Recombinant Proteins/genetics/metabolism | 3 | 0.0 |
Reverse Transcriptase Polymerase Chain Reaction | 2 | 0.0 |
Serine | 2 | 2.0 |
Threonine | 2 | 3.0 |
Catalysis | 3 | 0.0 |
Hydrogen Peroxide/pharmacology | 3 | 1.0 |
Cloning, Molecular | 6 | 0.0 |
Protein Kinase C/genetics/*metabolism | 2 | 6.0 |
Protein-Serine-Threonine Kinases/*chemistry/*metabolism | 2 | 8.0 |
Sequence Alignment | 4 | 0.0 |
Proto-Oncogene Proteins/chemistry/*metabolism | 3 | 5.0 |
Proto-Oncogene Proteins/genetics/metabolism | 4 | 2.0 |
*Tumor Suppressor Proteins | 2 | 0.0 |
Sequence Analysis | 2 | 0.0 |
Threonine/metabolism | 6 | 6.0 |
Recombinant Fusion Proteins/chemistry/genetics/metabolism | 2 | 1.0 |
Escherichia coli/genetics | 2 | 0.0 |
Proto-Oncogene Proteins/genetics/*metabolism | 2 | 0.0 |
Base Sequence | 6 | 0.0 |
Green Fluorescent Proteins | 2 | 0.0 |
Luminescent Proteins/genetics | 2 | 1.0 |
Phenotype | 2 | 0.0 |
Proto-Oncogene Proteins/genetics | 2 | 0.0 |
Proto-Oncogene Proteins/antagonists & inhibitors/genetics/*metabolism | 2 | 28.0 |
Retinoblastoma Protein/metabolism | 2 | 0.0 |
Signal Transduction/drug effects/genetics | 2 | 5.0 |
Tumor Suppressor Proteins/metabolism | 2 | 1.0 |
Recombinant Proteins/chemistry/genetics/metabolism | 3 | 0.0 |
Consensus Sequence | 2 | 0.0 |
Insulin/*metabolism | 2 | 2.0 |
Receptor, Insulin/metabolism | 3 | 3.0 |
Mutation/genetics | 3 | 0.0 |
DNA Primers | 2 | 0.0 |
Protein Kinases/chemistry/*genetics/metabolism | 2 | 100.0 |
Protein-Serine-Threonine Kinases/chemistry/*genetics/*metabolism | 2 | 13.0 |
Protein-Tyrosine Kinase/genetics/metabolism | 2 | 2.0 |
Cyclic AMP-Dependent Protein Kinases/metabolism | 2 | 1.0 |
Cell Membrane/enzymology | 2 | 0.0 |
Phosphatidylinositol Phosphates/*metabolism | 2 | 6.0 |
Protein-Serine-Threonine Kinases/biosynthesis/genetics/*metabolism | 2 | 28.0 |
Protein-Serine-Threonine Kinases/genetics/metabolism | 3 | 2.0 |
Adipocytes/*metabolism | 2 | 4.0 |
Hypoglycemic Agents/*pharmacology | 2 | 4.0 |
Insulin/*pharmacology | 2 | 0.0 |
Protein-Serine-Threonine Kinases/*metabolism/*physiology | 2 | 14.0 |
CHO Cells | 3 | 0.0 |
Hamsters | 3 | 0.0 |
Tyrosine/metabolism | 3 | 0.0 |
Ribosomal Protein S6 Kinases, 70-kDa/metabolism | 3 | 15.0 |
Protein-Serine-Threonine Kinases/*chemistry/metabolism | 2 | 12.0 |
MAP Kinase Signaling System/*physiology | 4 | 4.0 |
Thymidylate Synthase/metabolism | 2 | 9.0 |
Rats, Sprague-Dawley | 2 | 0.0 |
Protein-Serine-Threonine Kinases/genetics | 2 | 1.0 |
Cell-Free System | 2 | 0.0 |
Cytosol/metabolism | 2 | 0.0 |
NF-kappa B/metabolism | 2 | 0.0 |
Tumor Necrosis Factor-alpha/pharmacology | 2 | 0.0 |
*Gene Expression Regulation, Enzymologic | 2 | 0.0 |
Growth Substances/metabolism | 2 | 1.0 |
14-3-3 Proteins | 2 | 1.0 |
Phosphoproteins/*chemistry | 2 | 6.0 |
