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Taipei Medical University

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Gene Symbol
Gene NameAliasesPrevious_Symbol

MLH1

mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)HNPCCmutL (E. coli) homolog 1 (colon cancer, nonpolyposis type 2)


Gene MLH1 gene interaction
View Neighborhood Gene

Result number fewer <<<< << < ALL > >> >>> more

MeSH term
FrequencyCondition_Probility

Adult

1260.0

Aged

970.0

Aged, 80 and over

440.0

*Base Pair Mismatch

3841.0

*DNA Repair

517.0

DNA-Binding Proteins/analysis

45.0

Female

2050.0

Humans

3770.0

Immunohistochemistry

660.0

Male

1720.0

Middle Aged

1550.0

Neoplasm Proteins/analysis

72.0

Proto-Oncogene Proteins/analysis

63.0

Research Support, Non-U.S. Gov't

2640.0

Base Sequence

400.0

DNA Mutational Analysis

581.0

Genomic Instability

212.0

Loss of Heterozygosity

182.0

Microsatellite Repeats/*genetics

3613.0

Molecular Sequence Data

500.0

Survival Rate

80.0

Tumor Markers, Biological/genetics/metabolism

212.0

Age of Onset

181.0

Amino Acid Sequence

160.0

Colorectal Neoplasms, Hereditary Nonpolyposis/*genetics/pathology

440.0

DNA, Neoplasm/chemistry/genetics

21.0

*DNA-Binding Proteins

1176.0

Family Health

151.0

Genotype

120.0

Mutation

390.0

Neoplasm Proteins/genetics

5311.0

Phenotype

380.0

Proto-Oncogene Proteins/genetics

315.0

Sequence Homology, Amino Acid

110.0

Adenosinetriphosphatase/genetics/metabolism

28.0

*Aneuploidy

44.0

Animals

550.0

*DNA Repair Enzymes

3940.0

DNA-Binding Proteins/genetics/metabolism

51.0

Exons

150.0

*Meiosis

412.0

Mice

450.0

Mice, Inbred C57BL

80.0

Mice, Mutant Strains

50.0

Microsatellite Repeats

524.0

Neoplasm Proteins/genetics/metabolism

43.0

Base Pair Mismatch

5030.0

*DNA Methylation

253.0

Endometrial Neoplasms/*genetics/metabolism/pathology

233.0

Neoplasm Proteins/biosynthesis/*genetics

99.0

Promoter Regions (Genetics)

120.0

Research Support, U.S. Gov't, P.H.S.

1230.0

*Germ-Line Mutation

266.0

Microsatellite Repeats/genetics

256.0

Predictive Value of Tests

80.0

Proto-Oncogene Proteins/biosynthesis/*genetics

58.0

DNA/*metabolism

30.0

DNA Damage

50.0

Models, Biological

40.0

Neoplasms/*genetics

41.0

Research Support, U.S. Gov't, Non-P.H.S.

150.0

DNA Repair

518.0

Immunohistochemistry/methods

30.0

Tumor Markers, Biological/*analysis

50.0

Base Pair Mismatch/genetics

2248.0

Child, Preschool

50.0

DNA Repair/genetics

3621.0

DNA, Neoplasm/*genetics

41.0

Epigenesis, Genetic

27.0

Gene Silencing

41.0

*Genomic Instability

215.0

Immunoenzyme Techniques

140.0

Infant

20.0

Neoplasm Proteins/*genetics/metabolism

128.0

Polymerase Chain Reaction

480.0

Promoter Regions (Genetics)/genetics

80.0

Tumor Cells, Cultured

240.0

*Adenosinetriphosphatase

2230.0

Cell Line

200.0

Cisplatin/pharmacology

42.0

*DNA Damage

71.0

DNA Primers

80.0

DNA-Binding Proteins/genetics/*physiology

20.0

*Escherichia coli Proteins

31.0

Mice, Knockout

70.0

Protein p53/metabolism

40.0

Reverse Transcriptase Polymerase Chain Reaction

150.0

Colorectal Neoplasms, Hereditary Nonpolyposis/*genetics

5760.0

Conserved Sequence

20.0

DNA Repair/physiology

25.0

DNA-Binding Proteins/*genetics/physiology

33.0

Mutation, Missense

70.0

Proto-Oncogene Proteins/physiology

32.0

Base Pair Mismatch/*genetics

2240.0

Colorectal Neoplasms/*genetics

2210.0

Endometrial Neoplasms/*genetics

816.0

Neoplasms, Multiple Primary/*genetics

25.0

Case-Control Studies

70.0

Colorectal Neoplasms, Hereditary Nonpolyposis/ethnology/*genetics

266.0

Comparative Study

480.0

Gene Frequency

50.0

*Genetic Predisposition to Disease

141.0

Germ-Line Mutation

399.0

Haplotypes

40.0

Heterozygote Detection

40.0

Neoplasm Proteins/*genetics

797.0

*Polymorphism, Single Nucleotide

30.0

Crossing Over, Genetic/genetics

213.0

In Situ Hybridization, Fluorescence

50.0

Meiosis/*genetics

37.0

Neoplasm Proteins/metabolism

71.0

Recombination, Genetic/*genetics

22.0

Spermatocytes/cytology/metabolism

215.0

Endometrial Neoplasms/chemistry/*genetics

250.0

Endometrium/*chemistry

28.0

*Microsatellite Repeats

2410.0

Neoplasm Proteins/analysis/*genetics

412.0

Proto-Oncogene Proteins/analysis/*genetics

24.0

*Drug Resistance, Neoplasm

21.0

*Antigens, Nuclear

21.0

CHO Cells

20.0

*DNA Helicases

20.0

DNA Repair/*genetics

4513.0

DNA, Complementary/analysis

20.0

Gene Expression

100.0

Hamsters

20.0

*Saccharomyces cerevisiae Proteins

181.0

Adenosinetriphosphatase/metabolism

32.0

Cell Nucleus/*metabolism

20.0

DNA Helicases/metabolism

27.0

DNA-Binding Proteins/metabolism

90.0

Fungal Proteins/metabolism

42.0

Models, Genetic

80.0

Nuclear Proteins/metabolism

30.0

Rats

20.0

*Recombination, Genetic

51.0

Time Factors

130.0

Age Factors

140.0

Cohort Studies

60.0

Neoplasm Staging

110.0

Proto-Oncogene Proteins/*genetics

606.0

Mutation/*physiology

21.0

Saccharomyces cerevisiae/genetics

40.0

DNA, Neoplasm/genetics

182.0

Germ-Line Mutation/*genetics

159.0

Pedigree

480.0

Cells, Cultured

90.0

Cloning, Molecular

80.0

DNA, Complementary/metabolism

20.0

Dose-Response Relationship, Drug

30.0

Electrophoresis, Polyacrylamide Gel

40.0

Fibroblasts/metabolism

20.0

Hydrolysis

20.0

Protein Binding

50.0

Protein Structure, Tertiary

20.0

Proteins/metabolism

30.0

DNA-Binding Proteins/*physiology

20.0

*Mutation

290.0

Neoplasm Proteins/*physiology

33.0

Ultraviolet Rays

50.0

Colorectal Neoplasms, Hereditary Nonpolyposis/epidemiology/*genetics

675.0

Genetic Predisposition to Disease

180.0

Genetic Screening/*methods

53.0

Sensitivity and Specificity

170.0

Chromatography, High Pressure Liquid/*methods

32.0

*DNA Mutational Analysis

31.0

Polymorphism, Genetic

80.0

Sequence Analysis, DNA

120.0

Endometrial Neoplasms/*genetics/pathology

515.0

English Abstract

90.0

Receptors, Estrogen/genetics

23.0

Colorectal Neoplasms/*genetics/pathology

78.0

Genes, ras

41.0

O(6)-Methylguanine-DNA Methyltransferase/genetics

27.0

Colorectal Neoplasms, Hereditary Nonpolyposis/*pathology

2100.0

Neoplasm Proteins/*analysis

30.0

Proto-Oncogene Proteins/*analysis/genetics

26.0

Colorectal Neoplasms/genetics

24.0

Colorectal Neoplasms, Hereditary Nonpolyposis/genetics

1739.0

*Gene Deletion

60.0

Polymerase Chain Reaction/*methods

30.0

Frameshift Mutation

61.0

Neoplasms, Second Primary/*genetics

29.0

Colonic Neoplasms/pathology

23.0

Disease Progression

60.0

Follow-Up Studies

70.0

DNA-Binding Proteins/*genetics

281.0

Gene Expression Regulation, Neoplastic

100.0

*Gene Rearrangement

20.0

Point Mutation

60.0

Polymerase Chain Reaction/methods

70.0

DNA/genetics

50.0

*Immunoglobulin Class Switching

215.0

In Vitro

20.0

Recombination, Genetic

90.0

Sequence Homology, Nucleic Acid

60.0

CpG Islands/genetics

64.0

Colorectal Neoplasms, Hereditary Nonpolyposis/*genetics/*metabolism

3100.0

Mutation/*genetics

90.0

DNA, Neoplasm/analysis

172.0

Neoplasm Proteins/genetics/*metabolism

31.0

Proto-Oncogene Proteins/genetics/metabolism

63.0

DNA/chemistry/genetics

30.0

Hela Cells

70.0

Sequence Analysis, DNA/methods

22.0

Colorectal Neoplasms/epidemiology/*genetics

215.0

Endometrial Neoplasms/epidemiology/*genetics

250.0

*Heterozygote

82.0

Variation (Genetics)/*genetics

20.0

Blotting, Western

70.0

*Mutation, Missense

40.0

DNA Mutational Analysis/*methods

53.0

DNA-Binding Proteins/genetics

151.0

Fungal Proteins/genetics

63.0

*Genes, Tumor Suppressor

60.0

Phosphoric Monoester Hydrolases/genetics

34.0

Plasmids

20.0

Receptors, Transforming Growth Factor beta/genetics

23.0

Tumor Suppressor Proteins/genetics

22.0

Macromolecular Substances

20.0

Protein Subunits

20.0

Syndrome

30.0

Colorectal Neoplasms/metabolism/pathology

212.0

DNA Repair/*physiology

76.0

Phosphorylation

40.0

Thioguanine/pharmacology

211.0

Genes, p53

71.0

Neoplasm Proteins/genetics/*physiology

36.0

Alleles

200.0

Colectomy

27.0

Colonoscopy

49.0

CpG Islands/*genetics

33.0

DNA Primers/genetics

20.0

Intestinal Mucosa/pathology

23.0

Mass Screening

31.0

Risk Assessment

50.0

Codon

20.0

Child

140.0

Rectal Neoplasms/*genetics/pathology

222.0

Prospective Studies

60.0

Prognosis

160.0

Survival Analysis

90.0

Disease-Free Survival

50.0

Retrospective Studies

50.0

Adolescent

150.0

Heterozygote

160.0

Netherlands/epidemiology

21.0

Registries

31.0

Risk Factors

130.0

Sex Factors

40.0

Fungal Proteins/*genetics

119.0

Gene Deletion

110.0

Reproducibility of Results

30.0

Colonic Neoplasms/*genetics/metabolism/pathology

210.0

Genes, APC

33.0

Tumor Markers, Biological/metabolism

20.0

*Codon, Nonsense

23.0

Colorectal Neoplasms, Hereditary Nonpolyposis/*genetics/metabolism

4100.0

*Exons

20.0

RNA, Messenger/biosynthesis/genetics

20.0

Genetic Screening

151.0

Incidence

90.0

Neoplasm Proteins/biosynthesis/genetics

53.0

Proto-Oncogene Proteins/biosynthesis/genetics

78.0

DNA Methylation

101.0

Glioblastoma/*genetics

22.0

Protein p53/genetics

21.0

3T3 Cells

20.0

Chromosome Painting

24.0

DNA-Binding Proteins/genetics/*metabolism

40.0

Meiosis/genetics

310.0

*Nuclear Proteins

20.0

Tissue Distribution

20.0

Transcription, Genetic

40.0

Transfection

60.0

Neoplasm Proteins/*metabolism

112.0

Proto-Oncogene Proteins/*metabolism

50.0

DNA Topoisomerases, Type II/*antagonists & inhibitors

28.0

Doxorubicin/pharmacology

31.0

Drug Resistance, Neoplasm

30.0

Ovarian Neoplasms/*genetics

20.0

Gene Expression Regulation, Neoplastic/genetics

42.0

*Gene Silencing

21.0

Promoter Regions (Genetics)/*genetics

20.0

Germ-Line Mutation/genetics

710.0

Exons/genetics

50.0

Ploidies

31.0

Likelihood Functions

21.0

*Variation (Genetics)

20.0

Breast Neoplasms/genetics

20.0

Genes, BRCA1

31.0

Ovarian Neoplasms/genetics

31.0

Carcinoma/*genetics/pathology

23.0

*Gene Expression Regulation, Neoplastic

70.0

Neoplasm Proteins/*biosynthesis

55.0

Neoplasms, Multiple Primary/*genetics/pathology

220.0

Proto-Oncogene Proteins/*biosynthesis

53.0

Genetic Screening/methods

54.0

Breast Neoplasms/*genetics

20.0

*Frameshift Mutation

21.0

DNA/genetics/metabolism

20.0

Tumor Markers, Biological/*metabolism

20.0

Diagnosis, Differential

40.0

Genetic Predisposition to Disease/genetics

30.0

Netherlands

21.0

Penetrance

21.0

Colonic Neoplasms/*genetics/pathology

24.0

Genes, ras/genetics

21.0

Multivariate Analysis

40.0

Statistics, Nonparametric

40.0

Colonic Neoplasms/genetics

46.0

Endometrial Neoplasms/genetics

425.0

Rectal Neoplasms/genetics

222.0

Stomach Neoplasms/genetics

312.0

Urologic Neoplasms/genetics

2100.0

*Genes, p53

20.0

Codon, Terminator/genetics

23.0

Colonic Neoplasms/drug therapy/genetics

250.0

Oligonucleotide Array Sequence Analysis

40.0

Blotting, Northern

30.0

DNA, Neoplasm/*analysis

52.0

*Gene Expression Profiling

20.0

Cell Nucleus/metabolism

40.0

DNA Replication

51.0

Precipitin Tests

30.0

*CpG Islands

22.0

Precancerous Conditions/genetics

29.0

Cytogenetic Analysis/methods

212.0

In Situ Hybridization, Fluorescence/*methods

22.0

Synaptonemal Complex/*genetics

2100.0

Carrier Proteins/*genetics

20.0

Chromatography, High Pressure Liquid

30.0

Loss of Heterozygosity/genetics

53.0

Nucleic Acid Denaturation

44.0

United States

20.0

Crosses, Genetic

50.0

Intestinal Neoplasms/genetics

250.0

Mice, Inbred BALB C

40.0

Mice, Transgenic

20.0

*Point Mutation

40.0

DNA, Neoplasm/*genetics/metabolism

218.0

Gene Expression Profiling

20.0

Dimerization

60.0

Tumor Markers, Biological/*biosynthesis

22.0

Colorectal Neoplasms, Hereditary Nonpolyposis/genetics/pathology

457.0

*Loss of Heterozygosity

61.0

DNA Mutational Analysis/methods

41.0

Sequence Analysis, RNA/*methods

240.0

*Sequence Deletion

41.0

Cytoskeletal Proteins/*biosynthesis

211.0

*Immunohistochemistry

22.0

Neoplasm Metastasis

20.0

Linkage (Genetics)

70.0

*Multidrug Resistance-Associated Proteins

611.0

Cell Cycle/drug effects

30.0

Drug Screening Assays, Antitumor

20.0

Hydrogen Peroxide/toxicity

28.0

Peroxides/*toxicity

250.0

Gene Expression Regulation, Neoplastic/*genetics

21.0

Lymphatic Metastasis

40.0

Neoplasm Proteins/deficiency/*genetics

222.0

CpG Islands

31.0

*Neoplasm Proteins

101.0

Proto-Oncogene Proteins/genetics/*metabolism

20.0

Regression Analysis

20.0

Adenomatous Polyposis Coli Protein

45.0

Neoplasm Proteins/biosynthesis

22.0

Protein Biosynthesis

40.0

Recurrence

20.0

Colorectal Neoplasms, Hereditary Nonpolyposis/diagnosis/*genetics

1083.0

Proto-Oncogene Proteins/analysis/genetics

414.0

Enzyme Inhibitors/pharmacology

30.0

Fluorescent Antibody Technique

40.0

DNA-Binding Proteins/biosynthesis/*genetics

32.0

In Situ Hybridization

20.0

Risk

40.0

*Acid Anhydride Hydrolases

41.0

*Chromosomes, Human, Pair 3

30.0

DNA/metabolism

40.0

Down-Regulation

20.0

Hybrid Cells

30.0

Mice, SCID

20.0

Proteins/*genetics

80.0

Genetic Markers

90.0

Tumor Markers, Biological/analysis

20.0

Dacarbazine/*analogs & derivatives/pharmacology

327.0

Drug Resistance, Neoplasm/*genetics

22.0

Dinucleotide Repeats

33.0

Colonic Neoplasms/*genetics

33.0

Mutation/genetics

70.0

Polymorphism, Single-Stranded Conformational

120.0

*Polymorphism, Genetic

60.0

Antineoplastic Agents/pharmacology

30.0

Carboplatin/pharmacology

222.0

Alternative Splicing/*genetics

31.0

Protein-Serine-Threonine Kinases/genetics

21.0

Proteins/genetics

111.0

Variation (Genetics)

30.0

BRCA2 Protein

50.0

Breast Neoplasms/diagnosis/*genetics

27.0

Transcription Factors/genetics

30.0

Neoplasm Invasiveness

30.0

DNA, Neoplasm/genetics/metabolism

22.0

Transcription Factors/*genetics

20.0

History, 19th Century

310.0

History, 20th Century

32.0

Colorectal Neoplasms/*genetics/metabolism

39.0

Sequence Deletion/genetics

21.0

DNA/analysis

30.0

DNA Primers/chemistry

30.0

Evolution, Molecular

30.0

*Founder Effect

32.0

Introns

40.0

Finland/epidemiology

32.0

Herpesvirus 4, Human/genetics

22.0

Cell Cycle Proteins/metabolism

30.0

Signal Transduction

20.0

Colorectal Neoplasms/diagnosis/*genetics

333.0

Genome, Human

30.0

Adenocarcinoma/*genetics

21.0

Diploidy

32.0

Chromosomal Instability/genetics

266.0

Colorectal Neoplasms, Hereditary Nonpolyposis/complications/*genetics

2100.0

Family

41.0

Proto-Oncogene Proteins/metabolism

40.0

RNA, Messenger/biosynthesis

30.0

Reverse Transcriptase Polymerase Chain Reaction/methods

30.0

Karyotyping

30.0

Mutation, Missense/*genetics

21.0

Fungal Proteins/*genetics/physiology

222.0

DNA, Complementary/genetics

20.0

DNA-Binding Proteins/*biosynthesis

32.0

Electrophoresis, Gel, Two-Dimensional

30.0

Saccharomyces cerevisiae/*genetics

63.0

Mice, Inbred Strains

20.0

RNA, Messenger/genetics

20.0

Species Specificity

30.0

Portugal

23.0

Genes, BRCA1/genetics

22.0

Genetic Predisposition to Disease/*genetics

41.0

Great Britain/epidemiology

21.0

Odds Ratio

20.0

Chromosome Aberrations

20.0

Neoplasm Proteins/analysis/genetics

28.0

Genetic Markers/genetics

40.0

Colorectal Neoplasms, Hereditary Nonpolyposis/*diagnosis/genetics

2100.0

Genetic Techniques

22.0

*Genetic Screening

73.0

DNA, Satellite/genetics

32.0

Genetic Complementation Test

30.0

Neoplasm Proteins

39.0

Adenomatous Polyposis Coli/genetics

310.0

Cell Survival

20.0

Chromosome Mapping

60.0

Chromosomes, Human, Pair 3

42.0

*Carrier Proteins

111.0

Immunoglobulin Class Switching/*genetics

220.0

Italy/epidemiology

31.0

Cytoskeletal Proteins/genetics

23.0

Protein Synthesis Inhibitors/pharmacology

20.0

Radiation, Ionizing

32.0

*Alleles

50.0

Neoplasms, Experimental/*genetics

216.0

Kinetics

20.0

Sequence Alignment

30.0

Cytoskeletal Proteins/*genetics

21.0

*Genes, APC

33.0

*Mutagenesis

23.0

Methylation

30.0

*Promoter Regions (Genetics)

50.0

DNA Transposable Elements

21.0

Sequence Deletion

30.0

Tumor Cells, Cultured/drug effects

20.0

Endometrial Neoplasms/complications/*genetics

266.0

Genes, Tumor Suppressor

50.0

Probability

20.0

Tumor Markers, Biological/genetics

22.0

Logistic Models

20.0

DNA Replication/genetics

23.0

DNA-Binding Proteins/*metabolism

40.0

Transcription, Genetic/genetics

20.0

*Proto-Oncogene Proteins

80.0

Haploidy

21.0

Genes, Tumor Suppressor/genetics

21.0

DNA, Neoplasm

43.0

DNA-Binding Proteins/*genetics/metabolism

51.0

Proto-Oncogene Proteins/*genetics/metabolism

32.0

RNA, Messenger/metabolism

30.0

Cell Line, Tumor

70.0

Homozygote

20.0

Neurofibromatosis 1/*genetics

21.0

Colorectal Neoplasms/*genetics/*pathology

28.0

Statistics

20.0

DNA Repair/genetics/*physiology

29.0

Oligonucleotide Probes/genetics

21.0

DNA-Binding Proteins/*analysis

23.0

Proteins/*analysis

21.0

Disease Susceptibility

60.0

Neoplasm Proteins/*deficiency/genetics

233.0

Organ Specificity

20.0

RNA, Messenger/analysis

30.0

Protein p53/physiology

22.0

Fungal Proteins/genetics/*metabolism

23.0

Nucleic Acid Heteroduplexes

36.0

Genes, p16

33.0

Blotting, Southern

30.0

Gene Amplification

20.0

RNA-Directed DNA Polymerase

21.0

Gene Rearrangement

20.0

Cell Differentiation

30.0

Finland

20.0

Genes, Fungal

32.0

Mutagenesis

50.0

DNA, Fungal/genetics

35.0

*Genes, Fungal

32.0

Chi-Square Distribution

20.0

*Repetitive Sequences, Nucleic Acid

41.0

Neoplasms/genetics

32.0

Genetic Counseling

21.0

Cell Transformation, Neoplastic/genetics

20.0

Chromosome Deletion

30.0

*Caenorhabditis elegans Proteins

43.0

Colorectal Neoplasms, Hereditary Nonpolyposis/blood/*genetics

2100.0

*Gene Conversion

26.0

*Homozygote

21.0

Cell Transformation, Neoplastic

20.0

Lymphatic Metastasis/pathology

22.0

Neoplasm Invasiveness/pathology

23.0

Neoplasm Proteins/*deficiency/physiology

2100.0

Protein p53/*genetics

21.0

Sex Distribution

31.0

Cost-Benefit Analysis

32.0

Carcinoma/*genetics

21.0

Protein p53/*metabolism

20.0

Adenosinetriphosphatase/*genetics/metabolism

27.0

Mass Screening/methods

24.0

Age Distribution

20.0

Genetic Predisposition to Disease/*ethnology

216.0

Jews/*genetics

32.0

United States/epidemiology

20.0

Colorectal Neoplasms, Hereditary Nonpolyposis/*epidemiology/*genetics

266.0

Gene Expression Regulation/*drug effects

20.0