Pubdiz
Taipei Medical University

Pubdiz from Gene to Disease ��] ��Ʈw

A B C D E F G H I J K L M N O P Q R X Y Z



Gene Symbol
Gene NameAliasesPrevious_Symbol

MGMT

O-6-methylguanine-DNA methyltransferase


Gene MGMT gene interaction
View Neighborhood Gene

Result number fewer <<<< << < ALL > >> >>> more

MeSH term
FrequencyCondition_Probility

Adult

750.0

Aged

640.0

Aged, 80 and over

260.0

Comparative Study

350.0

Female

1210.0

Humans

3180.0

Immunoenzyme Techniques

30.0

Lymphatic Metastasis

50.0

Male

1080.0

Middle Aged

870.0

Neoplasm Invasiveness

40.0

Neoplasm Staging

60.0

O(6)-Methylguanine-DNA Methyltransferase/*metabolism

1477.0

Research Support, Non-U.S. Gov't

2280.0

Smoking/*metabolism

24.0

Up-Regulation

30.0

Alleles

70.0

Cell Transformation, Neoplastic/genetics

31.0

Child

230.0

Child, Preschool

190.0

*DNA Methylation

8312.0

DNA, Neoplasm/chemistry/genetics

21.0

Gene Expression Profiling

40.0

*Gene Expression Regulation, Neoplastic

130.0

*Gene Silencing

42.0

*Genes, Tumor Suppressor

70.0

Infant

100.0

Neoplasm Proteins/biosynthesis/*genetics

22.0

Polymerase Chain Reaction

460.0

Promoter Regions (Genetics)/*genetics

141.0

Research Support, U.S. Gov't, P.H.S.

1240.0

Tumor Cells, Cultured

640.0

*Tumor Suppressor Proteins

70.0

Adolescent

260.0

Base Sequence

400.0

DNA Primers

80.0

DNA Repair/*genetics

113.0

*Genes, p53

61.0

Infant, Newborn

20.0

Mutation

200.0

O(6)-Methylguanine-DNA Methyltransferase/*genetics

2887.0

Polymorphism, Single-Stranded Conformational

60.0

Animals

860.0

Antineoplastic Agents/*pharmacology

171.0

Blotting, Northern

140.0

*Drug Resistance, Neoplasm

63.0

Glutathione Transferase/metabolism

30.0

Mice

530.0

Mice, Inbred BALB C

80.0

Neoplasm Transplantation

110.0

O(6)-Methylguanine-DNA Methyltransferase/metabolism

428.0

P-Glycoprotein/metabolism

23.0

Blotting, Western

290.0

CpG Islands/genetics

53.0

DNA, Neoplasm/metabolism

53.0

Fluorescent Antibody Technique, Indirect

20.0

Gene Silencing

113.0

Ligases/genetics/metabolism

28.0

O(6)-Methylguanine-DNA Methyltransferase/*genetics/*metabolism

6100.0

*Promoter Regions (Genetics)

180.0

RNA, Messenger/metabolism

80.0

Reverse Transcriptase Polymerase Chain Reaction

190.0

Biopsy

60.0

Case-Control Studies

60.0

Cell Transformation, Neoplastic

40.0

Disease Progression

100.0

Promoter Regions (Genetics)

390.0

Transcription, Genetic

160.0

Tissue Distribution

20.0

Carcinoma, Non-Small-Cell Lung/*genetics

34.0

DNA, Neoplasm/*analysis

21.0

Gene Expression Regulation, Neoplastic/genetics

21.0

Genetic Markers

30.0

Lung Neoplasms/*genetics

31.0

Tumor Markers, Biological/*analysis

30.0

CpG Islands/*genetics

1212.0

DNA, Neoplasm/*genetics

73.0

Immunohistochemistry

210.0

CpG Islands

207.0

DNA Methylation

192.0

Prognosis

120.0

Smoking/*adverse effects

20.0

Survival Rate

80.0

Protein p16/metabolism

23.0

Sensitivity and Specificity

30.0

Astrocytoma/*genetics

36.0

Brain Neoplasms/*genetics

21.0

Cadherins/metabolism

21.0

DNA-Binding Proteins/metabolism

30.0

Epigenesis, Genetic

27.0

Neoplasm Proteins/*metabolism

20.0

Sex Factors

20.0

Loss of Heterozygosity

60.0

English Abstract

140.0

Follow-Up Studies

50.0

Gene Expression Regulation, Neoplastic

160.0

Cell Division

70.0

Cell Line

240.0

Electrophoresis, Agar Gel

20.0

Flow Cytometry

40.0

Transfection

250.0

Adenocarcinoma/genetics

22.0

Colorectal Neoplasms/*genetics

31.0

Microsatellite Repeats/*genetics

31.0

Phenotype

100.0

Brain/enzymology

31.0

DNA Damage

80.0

DNA, Complementary/genetics

20.0

Enzyme Induction

30.0

Guanine/*analogs & derivatives/analysis

240.0

Liver/enzymology

20.0

Mice, Inbred C3H

71.0

Mice, Inbred C57BL

90.0

Mice, Transgenic

110.0

O(6)-Methylguanine-DNA Methyltransferase/genetics/*physiology

350.0

Recombinant Fusion Proteins/physiology

20.0

Transferrin/genetics

24.0

Transgenes

30.0

Drug Evaluation

20.0

Enzyme Inhibitors/pharmacology

50.0

Glutathione/metabolism

31.0

O(6)-Methylguanine-DNA Methyltransferase/genetics/*metabolism

1090.0

Plasmids

50.0

Protein p53/metabolism

20.0

Ca(2+)-Calmodulin Dependent Protein Kinase/genetics

625.0

DNA Primers/chemistry

60.0

Gene Expression

140.0

Glutathione Transferase/genetics

72.0

Isoenzymes/genetics

72.0

O(6)-Methylguanine-DNA Methyltransferase/genetics

1760.0

Protein p16/genetics

89.0

Receptors, Retinoic Acid/genetics

55.0

Transcription Factors/genetics

20.0

Transplantation, Heterologous

111.0

Antineoplastic Agents/*therapeutic use

82.0

*DNA Helicases

31.0

DNA Repair/genetics

84.0

DNA-Binding Proteins/genetics

60.0

Gene Expression Regulation, Neoplastic/drug effects

20.0

HT29 Cells

31.0

Mice, Nude

140.0

*Organic Cation Transport Proteins

414.0

Proteins/genetics

30.0

RNA, Neoplasm/genetics/metabolism

21.0

*Transcription Factors

30.0

Xenograft Model Antitumor Assays

31.0

Point Mutation

60.0

Analysis of Variance

20.0

Colorectal Neoplasms/enzymology

266.0

Immunohistochemistry/methods

20.0

Liver Neoplasms/*enzymology

28.0

Neoplasm Proteins/*analysis

20.0

O(6)-Methylguanine-DNA Methyltransferase/*analysis

375.0

Survival Analysis

130.0

Genes, Tumor Suppressor

101.0

Genetic Predisposition to Disease

20.0

DNA, Neoplasm/genetics

30.0

Gene Expression Regulation, Enzymologic

111.0

Genes, p53/*genetics

20.0

*Mutation

110.0

Cell Survival/drug effects

121.0

Drug Resistance, Neoplasm

132.0

Genetic Vectors

90.0

Hela Cells

210.0

Nimustine/*pharmacology

583.0

O(6)-Methylguanine-DNA Methyltransferase/*genetics/metabolism

642.0

RNA, Messenger/genetics

80.0

Retroviridae/genetics

30.0

Solubility

20.0

Structure-Activity Relationship

40.0

Cloning, Molecular

100.0

*DNA Repair

233.0

Escherichia coli/genetics

30.0

O(6)-Methylguanine-DNA Methyltransferase/*genetics/pharmacology

266.0

Lymphoma/*genetics

24.0

Mass Screening

21.0

DNA Mutational Analysis

50.0

Promoter Regions (Genetics)/genetics

90.0

Proto-Oncogene Proteins B-raf/*genetics

216.0

Drug Resistance

162.0

Enzyme Inhibitors/*pharmacology

50.0

Etoposide/pharmacology

21.0

RNA, Messenger/*metabolism

40.0

*Point Mutation

40.0

Alkylation

710.0

Base Pair Mismatch

53.0

CHO Cells

100.0

Cricetulus

20.0

*DNA Glycosylases

34.0

DNA-(Apurinic or Apyrimidinic Site) Lyase

46.0

Deoxyribonuclease IV (Phage T4-Induced)

48.0

Hamsters

140.0

Methylation

203.0

Mice, Knockout

40.0

Mutagenesis

30.0

Mutagens/toxicity

25.0

O(6)-Methylguanine-DNA Methyltransferase/physiology

266.0

Alkylating Agents/*toxicity

216.0

Carmustine/toxicity

457.0

Cells, Cultured

80.0

Colony-Forming Units Assay

20.0

*DNA Damage

71.0

Drug Resistance/*genetics

36.0

Hematopoietic Stem Cells/*drug effects/enzymology

250.0

Lomustine/toxicity

2100.0

Moloney murine leukemia virus/genetics

26.0

Nimustine/toxicity

3100.0

Retroviridae/*genetics

53.0

O(6)-Methylguanine-DNA Methyltransferase/*biosynthesis

466.0

Time Factors

180.0

*Carcinogens

26.0

DNA Adducts

22.0

Exons

50.0

Genes, ras/genetics

21.0

Heterozygote

20.0

Carcinoma/*genetics

21.0

Genes, p53/genetics

31.0

Stomach Neoplasms/*genetics

21.0

Antineoplastic Agents/pharmacology

71.0

Drug Resistance, Neoplasm/*genetics

66.0

*Genes, MDR

38.0

Microsatellite Repeats

30.0

Oligodendroglioma/*genetics

220.0

Chromosome Aberrations

20.0

Oncogenes

20.0

Drug Resistance, Neoplasm/physiology

320.0

RNA, Catalytic/*metabolism

213.0

Methylnitrosourea

333.0

Antineoplastic Agents, Alkylating/pharmacology

311.0

Chromosome Mapping

30.0

Genome, Human

20.0

Antineoplastic Agents, Alkylating/therapeutic use

313.0

Brain Neoplasms/*drug therapy

225.0

Carmustine/analogs & derivatives/*therapeutic use

2100.0

Glioma/*drug therapy

333.0

Antineoplastic Agents/therapeutic use

41.0

Combined Modality Therapy

60.0

Nimustine/therapeutic use

4100.0

Neoplasms/*genetics

20.0

Age Factors

20.0

Brain/*enzymology

31.0

Brain Neoplasms/*enzymology

535.0

*Acid Anhydride Hydrolases

31.0

Genes, p16/genetics

29.0

Isoenzymes/metabolism

20.0

DNA/metabolism

90.0

Neoplasm Metastasis

30.0

Treatment Outcome

70.0

Ca(2+)-Calmodulin Dependent Protein Kinase/*genetics

315.0

DNA, Neoplasm/genetics/metabolism

33.0

Polymerase Chain Reaction/methods

90.0

O(6)-Methylguanine-DNA Methyltransferase/biosynthesis/*genetics

6100.0

Cadherins/genetics

814.0

Risk Factors

60.0

Tissue Inhibitor of Metalloproteinase-3/genetics

535.0

Genes, Tumor Suppressor/*physiology

43.0

Blotting, Southern

70.0

Dacarbazine/*analogs & derivatives/*pharmacology

250.0

Dose-Response Relationship, Drug

110.0

*Genetic Vectors

20.0

Models, Genetic

70.0

Dacarbazine/*toxicity

2100.0

Guanine/analogs & derivatives/metabolism

320.0

Rats

140.0

Rats, Sprague-Dawley

40.0

Amino Acid Sequence

140.0

Molecular Sequence Data

410.0

Molecular Weight

40.0

Serine Endopeptidases/metabolism

21.0

Antineoplastic Agents, Alkylating/pharmacology/*therapeutic use

266.0

Disease-Free Survival

50.0

Gene Expression Regulation, Enzymologic/drug effects

21.0

*Endonucleases

33.0

*Polymorphism, Single Nucleotide

20.0

Sequence Analysis, DNA

50.0

Protein Biosynthesis

50.0

Cell Cycle/genetics

21.0

DNA Repair

314.0

Research Support, U.S. Gov't, Non-P.H.S.

160.0

Cell Cycle

50.0

Enzyme Activation

20.0

Prospective Studies

40.0

Retrospective Studies

50.0

Antineoplastic Agents, Alkylating/*pharmacology

923.0

Gene Targeting

20.0

Nitrogen Mustard Compounds/*pharmacology

337.0

Sister Chromatid Exchange/drug effects

526.0

Cell Line, Tumor

50.0

*CpG Islands

1012.0

Down-Regulation

70.0

Adenoma/genetics

36.0

Genes, ras/*genetics

33.0

Guanine/metabolism

211.0

Antimetabolites, Antineoplastic/*pharmacology

22.0

Fluorouracil/*pharmacology

25.0

Forecasting

20.0

*Gene Expression Profiling

40.0

*Models, Theoretical

23.0

*Oligonucleotide Array Sequence Analysis

21.0

Predictive Value of Tests

90.0

Regression Analysis

20.0

Stomach Neoplasms/*drug therapy/*genetics

2100.0

Cell Division/drug effects

40.0

*DNA-Binding Proteins

70.0

Enzyme Stability/genetics

27.0

Methylnitronitrosoguanidine/pharmacology

625.0

*Polymorphism, Genetic

50.0

Precipitin Tests

50.0

RNA, Messenger/biosynthesis

20.0

Brain Neoplasms/*genetics/pathology

34.0

Nimustine/pharmacology

571.0

RNA, Messenger/analysis

100.0

Tumor Cells, Cultured/drug effects

50.0

Brain/metabolism

20.0

Carmustine/*pharmacology

1157.0

Drug Synergism

100.0

Glioblastoma/*genetics/metabolism

216.0

Antineoplastic Agents/*toxicity

46.0

Tumor Cells, Cultured/*drug effects

24.0

O(6)-Methylguanine-DNA Methyltransferase/*antagonists & inhibitors

350.0

Drug Resistance, Multiple/*genetics

23.0

Enzyme Stability

31.0

*Gene Therapy

20.0

Guanine/*analogs & derivatives/pharmacology

1032.0

K562 Cells

20.0

Genes, p53

51.0

Brain Neoplasms/pathology

210.0

Carmustine/pharmacology

418.0

Transduction, Genetic

20.0

Carcinogens

45.0

Hypersensitivity

216.0

L-Lactate Dehydrogenase/analysis

25.0

Codon/genetics

30.0

Guanine/*analogs & derivatives/metabolism

624.0

*Mutagenesis

23.0

O(6)-Methylguanine-DNA Methyltransferase/*biosynthesis/genetics

266.0

Organ Specificity

20.0

Spleen/enzymology

26.0

Alkylating Agents/pharmacology

514.0

Alkylating Agents/*pharmacology

421.0

Drug Resistance, Neoplasm/genetics

34.0

Nitroso Compounds/therapeutic use

2100.0

Antineoplastic Agents, Alkylating/*therapeutic use

422.0

Brain Neoplasms/*drug therapy/*enzymology

3100.0

Glioma/*drug therapy/*enzymology

4100.0

Alkyl and Aryl Transferases/*metabolism

266.0

Crosses, Genetic

20.0

Lung/*enzymology

23.0

DNA-Binding Proteins/*genetics

30.0

Etoposide/toxicity

211.0

Neoplasm Proteins/*genetics

40.0

Proto-Oncogene Proteins/*genetics

20.0

*Transcription, Genetic

50.0

Genes, ras

31.0

Retroviridae

34.0

DNA Footprinting

20.0

Dexamethasone/*pharmacology

20.0

Sequence Deletion

30.0

Cell Differentiation

20.0

DNA, Complementary/*genetics

20.0

*Gene Transfer Techniques

20.0

Brain Neoplasms/*drug therapy/pathology

225.0

Guanine/analogs & derivatives/pharmacology

430.0

Methyl Methanesulfonate/pharmacology

25.0

Streptozocin/*pharmacology

375.0

3T3 Cells

50.0

Gene Expression Regulation

20.0

Methylnitronitrosoguanidine/toxicity

440.0

Recombinant Proteins/biosynthesis

30.0

Vincristine/toxicity

228.0

Ependymoma/enzymology

266.0

Medulloblastoma/enzymology

250.0

Apoptosis/genetics

20.0

*Models, Genetic

21.0

Mutagens/pharmacology

37.0

Sister Chromatid Exchange/*drug effects

310.0

Carmustine/*therapeutic use

250.0

Glioblastoma/drug therapy/*enzymology/*mortality

2100.0

Nitrosourea Compounds/*pharmacology

342.0

*Gene Expression Regulation, Enzymologic

61.0

Antibodies

20.0

Lung Neoplasms/*enzymology

28.0

DNA Adducts/genetics

240.0

Recombinant Proteins/biosynthesis/metabolism

21.0

Antibodies, Monoclonal

20.0

Binding Sites

50.0

Cell Nucleus/metabolism

40.0

Deoxyribonuclease I/metabolism

21.0

Epitope Mapping

31.0

Rabbits

20.0

Antineoplastic Agents/adverse effects

26.0

*Escherichia coli Proteins

31.0

Colon/metabolism

21.0

Colorectal Neoplasms/*genetics/pathology

44.0

Substrate Specificity

30.0

Tumor Cells, Cultured/drug effects/enzymology

412.0

Chromatin/metabolism

20.0

CpG Islands/*physiology

218.0

Cytosine/metabolism

38.0

Methyltransferases/*genetics

2726.0

O(6)-Methylguanine-DNA Methyltransferase

11065.0

T-Lymphocytes

20.0

Biological Markers

20.0

Bone Marrow Cells

20.0

Bone Marrow Transplantation

31.0

Methyltransferases/*genetics/metabolism

615.0

Chromatin/*metabolism

21.0

Gene Expression/drug effects

30.0

Methyltransferases/genetics/*metabolism

723.0

Restriction Mapping

100.0

RNA, Messenger/*genetics

20.0

Antineoplastic Agents/chemistry/*pharmacology

28.0

Methyltransferases/*antagonists & inhibitors

215.0

China

20.0

Gene Amplification

20.0

Binding Sites/genetics

20.0

DNA/*genetics

30.0

Escherichia coli/enzymology/genetics

23.0

Mutagenesis, Site-Directed

40.0

Cell Compartmentation

20.0

Protein Binding

40.0

Antineoplastic Combined Chemotherapy Protocols/*therapeutic use

40.0

Cisplatin/administration & dosage

41.0

Gene Expression Regulation, Neoplastic/*drug effects

20.0

Carmustine/*toxicity

466.0

Methyltransferases/*metabolism

1927.0

Cell Nucleus/enzymology

33.0

Liver/*enzymology

20.0

Bronchoalveolar Lavage

28.0

Sulfites/pharmacology

26.0

Central Nervous System Neoplasms/*genetics

321.0

Ependymoma/*genetics

218.0

Methyltransferases/analysis/*metabolism

266.0

Sequence Homology, Amino Acid

40.0

Transcription Factor, Sp1/metabolism

20.0

Antibodies, Monoclonal/immunology

20.0

Recombinant Fusion Proteins/metabolism

40.0

Codon

30.0

L-Lactate Dehydrogenase/metabolism

21.0

Lymphocytes/enzymology

22.0

Pharmacogenetics

21.0

RNA, Messenger/genetics/metabolism

20.0

Antineoplastic Agents, Alkylating/*toxicity

220.0

Deoxyguanosine/*analogs & derivatives/pharmacology

233.0

Kinetics

100.0

Methyltransferases/antagonists & inhibitors

333.0

Methyltransferases/*physiology

571.0

Multivariate Analysis

20.0

Proportional Hazards Models

20.0

Gene Transfer Techniques

20.0

DNA Probes

30.0

Glioma/enzymology

233.0

Caspases/genetics

312.0

In Vitro

30.0

Reference Values

50.0

Ethylnitrosourea/*analogs & derivatives/pharmacology

266.0

Methyltransferases/antagonists & inhibitors/*metabolism

333.0

Chemotherapy, Adjuvant

20.0

Methyltransferases/genetics

211.0

Neoplasm Recurrence, Local

20.0

RNA, Neoplasm/metabolism

22.0

Precancerous Conditions/*genetics/pathology

210.0

Drug Administration Schedule

20.0

DNA/analysis

20.0

Nuclear Proteins/genetics

31.0

Genes, Structural

40.0

Cell Adhesion/physiology

20.0

Colonic Neoplasms/drug therapy/enzymology

266.0

Culture Media

20.0

Drug Screening Assays, Antitumor

41.0

Medulloblastoma/*drug therapy/*enzymology

2100.0

Brain Neoplasms/*enzymology/pathology

225.0

Breast Neoplasms/*enzymology/pathology

26.0

*Gene Expression

40.0

*Genes, ras

31.0

Cattle

20.0

Astrocytoma/enzymology

240.0

Carmustine/administration & dosage

215.0

Streptozocin/administration & dosage

233.0

Tumor Stem Cell Assay

21.0

Clone Cells

20.0

Methyltransferases/biosynthesis/*genetics

360.0

Methylenetetrahydrofolate Reductase (NADPH2)/*genetics

21.0

Neoplasm Proteins/genetics

71.0

Polymorphism, Genetic

20.0

Tumor Cells, Cultured/*enzymology

225.0

Methyltransferases/metabolism

26.0

Thioguanine/pharmacology

211.0

Escherichia coli/enzymology

23.0

Oligodeoxyribonucleotides

20.0

Glioblastoma/*drug therapy

228.0

Methyltransferases/*analysis

330.0

DNA/*metabolism

51.0

Electrophoresis, Polyacrylamide Gel

30.0

Antibody Specificity

20.0

Gene Expression/genetics

31.0

Cell Survival

20.0

Polymorphism, Restriction Fragment Length

20.0

Nucleic Acid Hybridization

30.0

Sequence Homology, Nucleic Acid

20.0

*Genotype

20.0

Odds Ratio

20.0

p14ARF Protein/genetics

523.0

Genes, Structural, Neoplasm/genetics

28.0

O(6)-Methylguanine-DNA Methyltransferase/*biosynthesis/*genetics

2100.0

Chronic Disease

20.0

Retinoblastoma Protein/genetics

25.0

Neoplasms/*genetics/*metabolism

240.0

Japan

30.0

Neoplasm Proteins/*biosynthesis

22.0

Proto-Oncogene Proteins/*biosynthesis

21.0

Adenoma/*genetics/pathology

27.0

Adenomatous Polyposis Coli Protein/genetics

212.0

Germ-Line Mutation

20.0

Genes, APC

22.0