MeSH term
Frequency | Condition_Probility | Amino Acid Sequence | 41 | 0.0 |
Animals | 75 | 0.0 |
Cell Line | 44 | 0.0 |
Enzyme Activation | 31 | 0.0 |
Humans | 167 | 0.0 |
Jurkat Cells | 45 | 3.0 |
Lymphocyte Specific Protein Tyrosine Kinase p56(lck)/genetics/*metabolism | 4 | 57.0 |
Mice | 48 | 0.0 |
Molecular Sequence Data | 52 | 0.0 |
Mutation | 10 | 0.0 |
*Nuclear Proteins | 4 | 0.0 |
Research Support, U.S. Gov't, P.H.S. | 82 | 0.0 |
Transcription, Genetic | 5 | 0.0 |
Transfection | 23 | 0.0 |
Cell Line, Transformed | 3 | 0.0 |
Enzyme Activation/immunology | 5 | 3.0 |
Lymphocyte Activation/*immunology | 2 | 0.0 |
Membrane Microdomains/metabolism | 2 | 6.0 |
Proline/metabolism | 2 | 3.0 |
Protein-Tyrosine Kinase/*metabolism | 25 | 3.0 |
Receptors, Antigen, T-Cell/immunology/metabolism/*physiology | 3 | 75.0 |
Receptors, Immunologic/*physiology | 2 | 1.0 |
Research Support, Non-U.S. Gov't | 137 | 0.0 |
Tyrosine/metabolism | 20 | 1.0 |
English Abstract | 3 | 0.0 |
Multigene Family | 2 | 0.0 |
*Oligonucleotide Array Sequence Analysis | 2 | 1.0 |
Protein-Tyrosine Kinase/*genetics/metabolism | 2 | 4.0 |
Tumor Cells, Cultured | 25 | 0.0 |
Tumor Markers, Biological | 2 | 0.0 |
Phosphorylation/drug effects | 7 | 0.0 |
Male | 12 | 0.0 |
Mice, Inbred BALB C | 5 | 0.0 |
Phosphorylation | 65 | 0.0 |
Phosphotyrosine/metabolism | 9 | 2.0 |
Models, Molecular | 3 | 0.0 |
Protein Binding | 22 | 0.0 |
Protons | 2 | 2.0 |
Spectrometry, Fluorescence | 2 | 0.0 |
*src Homology Domains | 3 | 1.0 |
Protein Processing, Post-Translational | 3 | 0.0 |
Protein Structure, Tertiary | 10 | 0.0 |
Protein-Tyrosine Kinase/metabolism | 19 | 2.0 |
Receptors, Antigen, T-Cell/metabolism | 13 | 7.0 |
Research Support, U.S. Gov't, Non-P.H.S. | 10 | 0.0 |
T-Lymphocytes/immunology/metabolism | 3 | 2.0 |
Ubiquitin/*metabolism | 2 | 1.0 |
src Homology Domains | 14 | 2.0 |
Amino Acid Motifs | 4 | 0.0 |
*Antigens, CD3 | 2 | 10.0 |
COS Cells | 9 | 0.0 |
Chimeric Proteins/metabolism | 5 | 2.0 |
Lymphocyte Specific Protein Tyrosine Kinase p56(lck)/metabolism | 16 | 29.0 |
Phosphotyrosine/*metabolism | 2 | 3.0 |
Signal Transduction | 33 | 0.0 |
Blotting, Western | 10 | 0.0 |
Cytoplasm/metabolism | 4 | 0.0 |
DNA Mutational Analysis | 3 | 0.0 |
Electrophoresis, Polyacrylamide Gel | 3 | 0.0 |
Gene Deletion | 2 | 0.0 |
Glutathione Transferase/metabolism | 4 | 0.0 |
Membrane Proteins/*chemistry/metabolism | 2 | 9.0 |
Point Mutation | 6 | 0.0 |
Precipitin Tests | 11 | 0.0 |
Proto-Oncogene Proteins/metabolism | 11 | 0.0 |
Recombinant Fusion Proteins/metabolism | 11 | 0.0 |
src-Family Kinases/chemistry/*metabolism | 2 | 28.0 |
Base Sequence | 17 | 0.0 |
Cloning, Molecular | 11 | 0.0 |
DNA Primers | 4 | 0.0 |
Lymphocyte Activation | 15 | 0.0 |
Protein-Tyrosine Kinase/genetics/*metabolism | 5 | 3.0 |
Hamsters | 3 | 0.0 |
Neoplasm Metastasis | 2 | 0.0 |
T-Lymphocytes, Cytotoxic/*immunology | 2 | 0.0 |
DNA-Binding Proteins/*metabolism | 2 | 0.0 |
Nuclear Proteins/metabolism | 2 | 0.0 |
Oncogene Proteins/metabolism | 2 | 2.0 |
Phosphoproteins/*metabolism | 5 | 1.0 |
Signal Transduction/immunology | 5 | 1.0 |
ras GTPase-Activating Proteins/metabolism | 2 | 15.0 |
src-Family Kinases/metabolism | 9 | 4.0 |
Adult | 11 | 0.0 |
Child | 2 | 0.0 |
Genotype | 2 | 0.0 |
Models, Biological | 10 | 0.0 |
T-Lymphocytes/*metabolism | 10 | 2.0 |
Cell Line, Tumor | 7 | 0.0 |
Protein-Tyrosine Kinase/*antagonists & inhibitors | 2 | 1.0 |
*Antigens, CD | 3 | 0.0 |
DNA, Complementary | 4 | 0.0 |
Female | 14 | 0.0 |
Lymphocyte Specific Protein Tyrosine Kinase p56(lck)/genetics | 3 | 60.0 |
Membrane Proteins/genetics | 2 | 0.0 |
Middle Aged | 8 | 0.0 |
*Cell Cycle Proteins | 2 | 0.0 |
Cells, Cultured | 7 | 0.0 |
Crosses, Genetic | 3 | 0.0 |
Ligands | 4 | 0.0 |
Mice, Inbred C57BL | 11 | 0.0 |
Mice, Transgenic | 3 | 0.0 |
Vanadates/pharmacology | 5 | 3.0 |
*Adaptor Proteins, Signal Transducing | 10 | 0.0 |
Gene Expression Regulation, Enzymologic | 2 | 0.0 |
Immunoblotting | 4 | 0.0 |
Kinetics | 16 | 0.0 |
Plasmids/metabolism | 5 | 0.0 |
Proteins/metabolism | 6 | 0.0 |
Receptors, Antigen, T-Cell/*metabolism | 15 | 10.0 |
*Signal Transduction | 20 | 1.0 |
Time Factors | 13 | 0.0 |
Genes, Reporter | 3 | 0.0 |
Interleukin-2/genetics | 3 | 3.0 |
Isoenzymes/metabolism | 4 | 0.0 |
Phospholipase C/metabolism | 2 | 0.0 |
T-Lymphocytes/enzymology/immunology | 2 | 16.0 |
Mutagenesis, Site-Directed | 10 | 0.0 |
Sequence Alignment | 3 | 0.0 |
Sequence Homology, Amino Acid | 6 | 0.0 |
Structure-Activity Relationship | 2 | 0.0 |
Substrate Specificity | 7 | 0.0 |
Signal Transduction/physiology | 2 | 0.0 |
Cell Division | 7 | 0.0 |
Dose-Response Relationship, Drug | 3 | 0.0 |
Enzyme Inhibitors/pharmacology | 6 | 0.0 |
Genes, Dominant | 2 | 0.0 |
Lymphocyte Specific Protein Tyrosine Kinase p56(lck)/genetics/metabolism | 3 | 37.0 |
Pyrazoles/pharmacology | 2 | 4.0 |
Pyrimidines/pharmacology | 3 | 2.0 |
Lymphocyte Specific Protein Tyrosine Kinase p56(lck)/*metabolism | 16 | 40.0 |
Antigens, CD4/metabolism | 3 | 0.0 |
Quinones/pharmacology | 3 | 2.0 |
Antibodies, Monoclonal/pharmacology | 4 | 0.0 |
Antigens, CD3/metabolism | 8 | 4.0 |
Enzyme Activation/drug effects | 5 | 0.0 |
Ionophores/pharmacology | 2 | 1.0 |
Membrane Proteins/metabolism | 6 | 1.0 |
Mitogen-Activated Protein Kinases/metabolism | 3 | 0.0 |
Protein Kinase C/metabolism | 3 | 0.0 |
Mice, Inbred DBA | 3 | 0.0 |
Enzyme Activation/genetics | 2 | 2.0 |
Protein Structure, Secondary | 2 | 0.0 |
Receptors, Antigen, T-Cell/genetics/*metabolism | 3 | 16.0 |
Recombinant Proteins/metabolism | 8 | 0.0 |
Sequence Deletion | 5 | 0.0 |
Tyrosine/*metabolism | 5 | 1.0 |
src Homology Domains/genetics | 2 | 3.0 |
Binding Sites | 11 | 0.0 |
Hydrogen Peroxide/pharmacology | 2 | 0.0 |
Peptide Mapping | 3 | 0.0 |
Phosphotyrosine/analysis | 2 | 3.0 |
src-Family Kinases/*metabolism | 7 | 4.0 |
Protein Kinase C/*metabolism | 3 | 1.0 |
Tyrosine | 2 | 1.0 |
T-Lymphocytes/metabolism | 3 | 1.0 |
Up-Regulation | 2 | 0.0 |
Membrane Microdomains/*metabolism | 2 | 4.0 |
Proto-Oncogene Proteins/*metabolism | 13 | 1.0 |
Comparative Study | 11 | 0.0 |
Lymphocyte Specific Protein Tyrosine Kinase p56(lck)/biosynthesis | 2 | 66.0 |
Ubiquitins/*metabolism | 2 | 1.0 |
Receptors, Antigen, T-Cell/*physiology | 4 | 2.0 |
Signal Transduction/*physiology | 6 | 0.0 |
T-Lymphocytes/*physiology | 6 | 2.0 |
3T3 Cells | 3 | 0.0 |
Recombinant Proteins/chemistry/metabolism | 2 | 0.0 |
Restriction Mapping | 4 | 0.0 |
Antibodies | 2 | 0.0 |
Antigens, CD95/*metabolism | 2 | 1.0 |
Carrier Proteins/metabolism | 4 | 0.0 |
Solubility | 4 | 0.0 |
Cell Transformation, Neoplastic/*genetics | 2 | 1.0 |
DNA-Binding Proteins/metabolism | 5 | 0.0 |
Proto-Oncogene Proteins/*genetics | 3 | 0.0 |
Transcription Factors/metabolism | 3 | 0.0 |
*Ubiquitin-Protein Ligases | 2 | 0.0 |
Flow Cytometry | 5 | 0.0 |
Ionomycin/pharmacology | 3 | 1.0 |
Signal Transduction/*immunology | 3 | 0.0 |
Tetradecanoylphorbol Acetate/pharmacology | 7 | 0.0 |
Signal Transduction/drug effects | 3 | 0.0 |
src-Family Kinases/*antagonists & inhibitors | 3 | 18.0 |
Protein Binding/immunology | 2 | 1.0 |
src Homology Domains/*immunology | 2 | 14.0 |
Crystallography, X-Ray | 2 | 0.0 |
Lymphocyte Specific Protein Tyrosine Kinase p56(lck)/*chemistry | 2 | 100.0 |
Herpesvirus 2, Saimiriine/*metabolism | 2 | 50.0 |
Viral Proteins/*metabolism | 2 | 3.0 |
Antigens, CD28/*metabolism | 2 | 1.0 |
Promoter Regions (Genetics) | 9 | 0.0 |
Trans-Activation (Genetics) | 2 | 0.0 |
Gene Products, nef/genetics/*metabolism | 3 | 9.0 |
HIV-1/*metabolism | 2 | 0.0 |
Recombinant Fusion Proteins/genetics/metabolism | 2 | 0.0 |
Antigens, CD4/*metabolism | 4 | 1.0 |
Biological Transport | 2 | 0.0 |
Macromolecular Substances | 3 | 0.0 |
Tetradecanoylphorbol Acetate/*pharmacology | 2 | 0.0 |
HIV-1/*physiology | 4 | 0.0 |
Lymphocyte Activation/*physiology | 2 | 2.0 |
Microscopy, Fluorescence | 2 | 0.0 |
Ca(2+)-Calmodulin Dependent Protein Kinase/metabolism | 4 | 1.0 |
Calcium/metabolism | 3 | 0.0 |
*Membrane Proteins | 3 | 0.0 |
Mitogen-Activated Protein Kinase 1 | 2 | 1.0 |
Mitogen-Activated Protein Kinase 3 | 4 | 0.0 |
*Mitogen-Activated Protein Kinases | 3 | 0.0 |
Phosphoproteins/metabolism | 3 | 0.0 |
ras Proteins/*metabolism | 2 | 1.0 |
In Vitro | 6 | 0.0 |
Prognosis | 2 | 0.0 |
1-Phosphatidylinositol 3-Kinase/metabolism | 3 | 0.0 |
ras Proteins/metabolism | 2 | 1.0 |
Antigens, CD8/metabolism | 2 | 3.0 |
Cell Separation | 3 | 0.0 |
Drug Synergism | 3 | 0.0 |
Signal Transduction/drug effects/*immunology | 2 | 5.0 |
Thymus Gland/cytology | 2 | 2.0 |
Muromonab-CD3/pharmacology | 2 | 2.0 |
T-Lymphocytes | 3 | 1.0 |
Cell Differentiation | 3 | 0.0 |
Cell Lineage | 2 | 0.0 |
Lymphocyte Specific Protein Tyrosine Kinase p56(lck)/*physiology | 4 | 40.0 |
Receptors, Antigen, T-Cell/genetics | 2 | 2.0 |
src Homology Domains/immunology | 2 | 7.0 |
Cell Membrane/metabolism | 5 | 0.0 |
Lymphocyte Specific Protein Tyrosine Kinase p56(lck)/analysis | 2 | 33.0 |
Cell Fractionation | 3 | 1.0 |
Mice, Inbred C3H | 3 | 0.0 |
Mice, Mutant Strains | 3 | 0.0 |
RNA, Messenger/analysis | 3 | 0.0 |
Species Specificity | 3 | 0.0 |
Signal Transduction/*drug effects | 3 | 0.0 |
Gene Expression | 8 | 0.0 |
Tissue Distribution | 2 | 0.0 |
RNA, Messenger/genetics | 6 | 0.0 |
RNA, Neoplasm/genetics | 2 | 0.0 |
T-Lymphocytes/enzymology | 3 | 7.0 |
Clonal Anergy | 2 | 5.0 |
Cross-Linking Reagents | 2 | 0.0 |
Interleukin-2/biosynthesis | 3 | 0.0 |
Peptides/chemistry/metabolism | 2 | 4.0 |
Recombinant Proteins/biosynthesis | 3 | 0.0 |
Hela Cells | 4 | 0.0 |
T-Lymphocytes/*immunology | 7 | 0.0 |
Genes, ras/genetics | 2 | 1.0 |
Fluorescent Antibody Technique | 2 | 0.0 |
Rats | 7 | 0.0 |
Rats, Wistar | 2 | 0.0 |
Cercopithecus aethiops | 3 | 0.0 |
Conserved Sequence | 2 | 0.0 |
Lymphocyte Specific Protein Tyrosine Kinase p56(lck) | 54 | 24.0 |
Phosphotyrosine | 10 | 3.0 |
Spodoptera | 2 | 0.0 |
JNK Mitogen-Activated Protein Kinases | 2 | 0.0 |
MAP Kinase Kinase 1 | 3 | 1.0 |
Membrane Proteins/*metabolism | 2 | 0.0 |
*Mitogen-Activated Protein Kinase Kinases | 2 | 2.0 |
Protein-Serine-Threonine Kinases/*metabolism | 3 | 0.0 |
Proto-Oncogene Proteins c-raf | 4 | 3.0 |
Polymerase Chain Reaction | 6 | 0.0 |
Proto-Oncogene Proteins/genetics/*metabolism | 3 | 0.0 |
Enzyme Precursors/metabolism | 3 | 2.0 |
Adolescent | 2 | 0.0 |
Aged | 6 | 0.0 |
Antigens, CD45/analysis | 2 | 0.0 |
G(M1) Ganglioside/*analysis | 2 | 100.0 |
Membrane Microdomains/*physiology | 2 | 10.0 |
Proto-Oncogene Proteins/*physiology | 4 | 1.0 |
Guanosine Diphosphate/metabolism | 2 | 1.0 |
1-Phosphatidylinositol 3-Kinase | 4 | 2.0 |
Antigens, CD4/biosynthesis/metabolism | 2 | 40.0 |
HIV Envelope Protein gp120/*pharmacology | 2 | 4.0 |
HIV-1/*immunology | 2 | 0.0 |
Spectrum Analysis, Mass | 2 | 0.0 |
T-Lymphocytes/*enzymology | 8 | 13.0 |
Antigens, CD45/*metabolism | 3 | 9.0 |
src-Family Kinases/antagonists & inhibitors/*metabolism | 2 | 11.0 |
Glutathione Transferase/genetics | 2 | 0.0 |
Antigens, CD/physiology | 2 | 0.0 |
Recombinant Proteins | 2 | 0.0 |
Clone Cells | 2 | 0.0 |
Aged, 80 and over | 2 | 0.0 |
Blotting, Northern | 8 | 0.0 |
*Promoter Regions (Genetics) | 2 | 0.0 |
Blotting, Southern | 2 | 0.0 |
Protein-Tyrosine Kinase/*genetics | 8 | 3.0 |
Recombinant Fusion Proteins/chemistry/genetics/metabolism | 2 | 1.0 |
src-Family Kinases/*physiology | 2 | 5.0 |
*Chromosome Mapping | 4 | 0.0 |
Hybrid Cells | 2 | 0.0 |
In Situ Hybridization | 2 | 0.0 |
Leukemia, T-Cell | 5 | 14.0 |
T-Lymphocytes/immunology/*physiology | 2 | 3.0 |
Protein-Tyrosine Kinase/chemistry/*metabolism | 3 | 8.0 |
Proto-Oncogene Proteins/chemistry/*metabolism | 2 | 3.0 |
*Lymphocyte Activation | 7 | 0.0 |
T-Lymphocytes/enzymology/*immunology | 3 | 13.0 |
Proto-Oncogene Proteins/genetics/metabolism | 2 | 1.0 |
Tyrosine/*analogs & derivatives/metabolism | 2 | 3.0 |
Luciferases/metabolism | 2 | 0.0 |
Receptors, Antigen, T-Cell/physiology | 4 | 2.0 |
Tyrosine/analogs & derivatives/metabolism | 5 | 4.0 |
Chromosome Mapping | 3 | 0.0 |
*Chromosomes, Human, Pair 1 | 5 | 1.0 |
*Chromosomes, Human, Pair 7 | 3 | 1.0 |
Codon | 2 | 0.0 |
Receptors, Antigen, T-Cell, alpha-beta/*genetics | 2 | 2.0 |
*Translocation, Genetic | 3 | 0.0 |
Interleukin-2/pharmacology | 2 | 0.0 |
*Lymphocytes | 2 | 12.0 |
Gene Expression Regulation, Leukemic | 2 | 2.0 |
*Genes, src | 2 | 5.0 |
Protein-Tyrosine Kinase/*physiology | 4 | 2.0 |
DNA Primers/chemistry | 2 | 0.0 |
Reference Values | 2 | 0.0 |
Receptors, Antigen, T-Cell/*immunology | 2 | 1.0 |
Antigens, CD8/*metabolism | 2 | 6.0 |
*src-Family Kinases | 3 | 7.0 |
T-Lymphocytes/cytology/*metabolism | 2 | 6.0 |
Gene Expression Regulation, Neoplastic | 2 | 0.0 |
Drug Screening Assays, Antitumor | 3 | 0.0 |
Mice, Nude | 5 | 0.0 |
Neoplasm Transplantation | 4 | 0.0 |
Genes, fos | 2 | 1.0 |
Interleukin-2/*pharmacology | 3 | 1.0 |
*Proto-Oncogenes | 3 | 0.0 |
T-Lymphocytes/physiology | 2 | 1.0 |
DNA, Complementary/metabolism | 2 | 0.0 |
*Gene Expression Regulation | 2 | 0.0 |
RNA, Messenger/metabolism | 3 | 0.0 |
Gene Expression Regulation | 4 | 0.0 |
DNA Probes | 2 | 0.0 |
*Down-Regulation | 2 | 0.0 |
*Oncogenes | 3 | 0.0 |
Antigens, CD4/analysis | 2 | 0.0 |
*Gene Expression Regulation, Neoplastic | 2 | 0.0 |
Sequence Homology, Nucleic Acid | 2 | 0.0 |
Protein Conformation | 2 | 0.0 |
Tyrosine/chemistry | 2 | 1.0 |
Cell Survival/drug effects | 2 | 0.0 |
NF-kappa B/*metabolism | 2 | 0.0 |
Membrane Microdomains/*chemistry | 2 | 25.0 |
