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Taipei Medical University

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Gene Symbol
Gene NameAliasesPrevious_Symbol

JAK2

Janus kinase 2 (a protein tyrosine kinase)


Gene JAK2 gene interaction
View Neighborhood Gene

Result number fewer <<<< << < ALL > >> >>> more

MeSH term
FrequencyCondition_Probility

Animals

3430.0

Humans

5510.0

Oligonucleotide Array Sequence Analysis

50.0

Aged

90.0

Aged, 80 and over

40.0

Fatal Outcome

20.0

Female

500.0

Swine

20.0

Cytokines/pharmacology

71.0

DNA/*metabolism

20.0

*DNA-Binding Proteins

30.0

Disease Models, Animal

50.0

Mice

1760.0

Mice, Inbred BALB C

110.0

Phosphoproteins/*metabolism

183.0

Protein-Tyrosine Kinase/*metabolism

14317.0

*Proto-Oncogene Proteins

34520.0

Research Support, Non-U.S. Gov't

4070.0

Research Support, U.S. Gov't, Non-P.H.S.

270.0

Signal Transduction/*physiology

534.0

Trans-Activation (Genetics)/drug effects

52.0

Transcription Factors/*metabolism

80.0

Tumor Cells, Cultured

1060.0

1-Phosphatidylinositol 3-Kinase/metabolism

142.0

DNA-Binding Proteins/physiology

103.0

Gene Expression Regulation/physiology

31.0

Human Growth Hormone/*physiology

333.0

Liver/metabolism

60.0

*Milk Proteins

12226.0

Mitogen-Activated Protein Kinases/physiology

32.0

Promoter Regions (Genetics)/genetics

40.0

Protein-Tyrosine Kinase/physiology

2117.0

Receptor, Insulin/physiology

216.0

Receptors, Somatotropin/physiology

480.0

Research Support, U.S. Gov't, P.H.S.

2270.0

Trans-Activators/physiology

1510.0

*Adaptor Proteins, Signal Transducing

312.0

*Adaptor Proteins, Vesicular Transport

124.0

Dimerization

201.0

Dose-Response Relationship, Drug

310.0

Male

480.0

Phosphoproteins/metabolism

152.0

Phosphorylation/drug effects

384.0

Phosphotyrosine/analysis

35.0

Prolactin/pharmacology

718.0

Protein Processing, Post-Translational/drug effects

54.0

Protein-Tyrosine Kinase/metabolism

11412.0

Proteins/metabolism

363.0

Signal Transduction/*drug effects

298.0

DNA-Binding Proteins/*metabolism

813.0

Enzyme Activation/drug effects

343.0

Interleukin-10/*pharmacology

22.0

JNK Mitogen-Activated Protein Kinases

61.0

Mitogen-Activated Protein Kinases/*metabolism

112.0

Phosphorylation

2723.0

Rats

840.0

Signal Transduction/drug effects

172.0

Trans-Activators/*metabolism

858.0

p38 Mitogen-Activated Protein Kinases

111.0

*Chromosome Aberrations

20.0

Hodgkin Disease/*genetics/pathology

222.0

Mutation

270.0

Endothelium, Vascular/cytology/*metabolism

21.0

Enzyme Activation

932.0

Gene Transfer Techniques

30.0

Signal Transduction/physiology

161.0

Amino Acid Sequence

770.0

Molecular Sequence Data

1080.0

Receptors, Interleukin/*chemistry

228.0

3T3 Cells

281.0

Fibroblasts/cytology/physiology

22.0

Interferon Type II/metabolism

20.0

Mitogen-Activated Protein Kinases/metabolism

212.0

Phosphoserine/*metabolism

27.0

*Protein-Serine-Threonine Kinases

91.0

Proto-Oncogene Proteins/metabolism

141.0

Cells, Cultured

750.0

*Intercellular Signaling Peptides and Proteins

20.0

RNA, Messenger/metabolism

90.0

Recombinant Fusion Proteins/pharmacology

44.0

Reverse Transcriptase Polymerase Chain Reaction

180.0

Signal Transduction

1402.0

Amino Acid Motifs

20.0

Cell Division

320.0

Cell Line

1740.0

Genes, myc

31.0

*Neoplasm Proteins

141.0

Protein-Tyrosine Kinase/*physiology

2317.0

*Receptors, Cytokine

107.0

Structure-Activity Relationship

210.0

Thrombopoietin/pharmacology

59.0

Tyrosine/metabolism

746.0

COS Cells

291.0

Carrier Proteins/genetics/*metabolism

30.0

Cell Fractionation

51.0

Cysteine Endopeptidases/*metabolism

20.0

Interferon Type II/pharmacology

91.0

Interleukin-3/pharmacology

145.0

*Intracellular Signaling Peptides and Proteins

294.0

Leupeptins/pharmacology

32.0

Multienzyme Complexes/antagonists & inhibitors/*metabolism

29.0

Proteasome Endopeptidase Complex

30.0

Protein-Tyrosine Kinase/genetics/*metabolism

96.0

Repressor Proteins/metabolism

52.0

Signal Transduction/drug effects/physiology

104.0

Tyrosine/*metabolism

257.0

Ubiquitin/*metabolism

31.0

Genes, Reporter

170.0

Mutagenesis, Site-Directed

240.0

Protein Structure, Tertiary

150.0

Trans-Activation (Genetics)

150.0

Transcription, Genetic

280.0

src-Family Kinases/*metabolism

42.0

Antigens, CD/metabolism

101.0

DNA-Binding Proteins/metabolism

814.0

Down-Regulation

90.0

Enzyme Inhibitors/pharmacology

552.0

Kinetics

350.0

Membrane Glycoproteins/metabolism

61.0

Protein-Tyrosine-Phosphatase/antagonists & inhibitors

25.0

*Signal Transduction/drug effects

99.0

English Abstract

70.0

Erythropoietin/pharmacology

97.0

Precipitin Tests

381.0

Receptors, Erythropoietin/*physiology

321.0

Trans-Activators/metabolism

919.0

DNA-Binding Proteins/*physiology

122.0

Gene Expression Regulation/drug effects/physiology

34.0

Granulocyte-Macrophage Colony-Stimulating Factor/*pharmacology

106.0

Immediate-Early Proteins/genetics

36.0

Macrophages/cytology/*physiology

323.0

Trans-Activators/*physiology

135.0

Endothelium, Vascular/cytology

20.0

Interferon Type II/*pharmacology

225.0

*Nuclear Proteins

20.0

Receptors, Interferon/biosynthesis

240.0

Mice, Knockout

90.0

Receptor, Epidermal Growth Factor/*physiology

21.0

Cell Differentiation

160.0

Interleukin-5/*pharmacology

1031.0

Phosphotyrosine/metabolism

4510.0

Protein Subunits

20.0

Receptors, Interleukin/metabolism

46.0

Amino Acid Substitution

20.0

Cell Division/drug effects/physiology

51.0

Mice, Transgenic

60.0

Receptors, Erythropoietin/genetics/*physiology

250.0

Acute Disease

40.0

Adolescent

60.0

Blotting, Southern

40.0

DNA Primers/chemistry

30.0

Genes, abl/*genetics

211.0

In Situ Hybridization, Fluorescence

110.0

Oncogene Proteins/genetics

22.0

*Philadelphia Chromosome

22.0

Blotting, Northern

70.0

Blotting, Western

410.0

Protein-Tyrosine Kinase/antagonists & inhibitors

115.0

Cytokines/*physiology

42.0

Growth Hormone/*physiology

519.0

Immunoblotting

140.0

Receptors, Somatotropin/metabolism

1043.0

Up-Regulation/*drug effects

22.0

Apoptosis/drug effects

101.0

Carrier Proteins/physiology

32.0

Cell Division/drug effects

371.0

DNA-Binding Proteins/genetics

40.0

Gene Expression

170.0

Leptin/*metabolism/pharmacology

2100.0

Mitogen-Activated Protein Kinase 1/metabolism

133.0

Mitogen-Activated Protein Kinase 3

193.0

Proteins/genetics

91.0

RNA, Messenger/analysis

120.0

*Receptors, Cell Surface

61.0

Recombinant Proteins

50.0

*Repressor Proteins

353.0

*Signal Transduction

904.0

Trans-Activators/genetics

41.0

*Transcription Factors

150.0

Transfection

1160.0

Hela Cells

110.0

Receptors, Cytokine/*metabolism

67.0

Up-Regulation

40.0

Receptors, Erythropoietin/*metabolism

423.0

Apoptosis

70.0

Cell Lineage

40.0

Cell Nucleus/metabolism

201.0

Cell Survival

70.0

Chromones/pharmacology

73.0

Flow Cytometry

80.0

Genes, Dominant

60.0

Luciferases/metabolism

91.0

Microscopy, Confocal

50.0

Morpholines/pharmacology

72.0

NF-kappa B/metabolism

40.0

Promoter Regions (Genetics)

140.0

Protein Binding

440.0

Time Factors

290.0

Granulocyte Colony-Stimulating Factor/pharmacology

21.0

Recombinant Fusion Proteins

30.0

Tyrosine

76.0

Carrier Proteins/*metabolism

60.0

DNA, Complementary/metabolism

60.0

*Gene Expression Regulation, Enzymologic

30.0

Plasmids/metabolism

70.0

Antineoplastic Agents/pharmacology

20.0

Butadienes/pharmacology

35.0

Imidazoles/pharmacology

31.0

Interleukin-13/*metabolism

216.0

Interleukin-4/*metabolism

37.0

Ligands

140.0

Nitriles/pharmacology

65.0

Pyridines/pharmacology

20.0

Tyrphostins/pharmacology

2516.0

MAP Kinase Signaling System

83.0

Models, Biological

200.0

Erythropoietin/metabolism/pharmacology

337.0

Receptors, Cell Surface/metabolism

40.0

Receptors, Erythropoietin/chemistry/*metabolism

360.0

Cell Line, Tumor

180.0

Fibroblasts

61.0

Gene Deletion

60.0

Protein-Tyrosine-Phosphatase/metabolism

97.0

Vanadates/pharmacology

53.0

DNA-Binding Proteins/analysis

33.0

*Gene Expression

20.0

Trans-Activators/analysis

26.0

Base Sequence

810.0

*Chromosomes, Human, Pair 12

20.0

DNA-Binding Proteins/*genetics

50.0

Middle Aged

100.0

Oncogene Proteins, Fusion/*genetics

52.0

*Protein-Tyrosine Kinase

41.0

Repressor Proteins/*genetics

20.0

*Translocation, Genetic

30.0

DNA/metabolism

181.0

Endothelium, Vascular/metabolism

20.0

Genistein/pharmacology

65.0

*Oxidative Stress

20.0

Protein-Tyrosine Kinase/antagonists & inhibitors/*metabolism

712.0

Gene Expression Profiling

30.0

Receptors, Granulocyte-Macrophage Colony-Stimulating Factor/*metabolism

444.0

Carrier Proteins/pharmacology

23.0

Caseins/genetics

218.0

Prolactin/*physiology

410.0

Promoter Regions (Genetics)/drug effects

21.0

Proteins/pharmacology

23.0

Receptors, Prolactin/*metabolism

416.0

Protein-Tyrosine Kinase/chemistry/*metabolism

25.0

Protein-Tyrosine-Phosphatase/*metabolism

86.0

Proteins/chemistry/*metabolism

22.0

Sequence Homology, Amino Acid

220.0

Substrate Specificity

90.0

Adult

140.0

Caseins/metabolism

29.0

Gene Expression Regulation/drug effects/*immunology

26.0

Phosphoproteins/genetics

21.0

RNA, Messenger/drug effects/metabolism

21.0

Signal Transduction/drug effects/*immunology

513.0

Trans-Activators/drug effects/metabolism

29.0

Cell Membrane/metabolism

50.0

Cyclodextrins/pharmacology

27.0

DNA-Binding Proteins/genetics/*metabolism

151.0

Fibroblasts/metabolism

40.0

Trans-Activators/genetics/*metabolism

154.0

*beta-Cyclodextrins

24.0

Apoptosis/*physiology

20.0

Flavonoids/pharmacology

103.0

Human Growth Hormone/*pharmacology

1642.0

Hydrogen Peroxide/pharmacology

20.0

In Situ Nick-End Labeling

20.0

Naphthalenes/pharmacology

33.0

Oxidants/pharmacology

23.0

Oxidative Stress

20.0

Proto-Oncogene Proteins c-raf/metabolism

44.0

Rats, Wistar

60.0

ras Proteins/metabolism

85.0

src-Family Kinases/metabolism

52.0

Antineoplastic Agents/*pharmacology

60.0

DNA, Neoplasm/biosynthesis

21.0

Protein-Tyrosine Kinase/*antagonists & inhibitors/metabolism

614.0

Tumor Stem Cell Assay

31.0

Tyrphostins/*pharmacology

416.0

Interferon Type II/*metabolism

46.0

Recombinant Fusion Proteins/metabolism

150.0

Two-Hybrid System Techniques

20.0

Erythropoietin/*pharmacology

1311.0

Hematopoietic Stem Cells/metabolism

21.0

K562 Cells

30.0

Phosphotyrosine/*metabolism

58.0

Growth Hormone/*pharmacology

2128.0

Protein Isoforms

20.0

Rats, Sprague-Dawley

150.0

Recombinant Proteins/metabolism

170.0

Cloning, Molecular

270.0

Growth Substances/*pharmacology

20.0

Macaca mulatta

20.0

Proto-Oncogene Proteins/physiology

32.0

Receptors, Cytokine/metabolism

88.0

Thrombopoietin/*physiology

315.0

CHO Cells/metabolism

25.0

Cell Transformation, Neoplastic/*metabolism

25.0

Hamsters

300.0

Kidney/cytology

21.0

*MAP Kinase Kinase Kinase 1

21.0

Mitogen-Activated Protein Kinase 8

33.0

Protein-Serine-Threonine Kinases/metabolism

101.0

Rats, Inbred BUF

29.0

Serine/*metabolism

22.0

Transcription Factors/metabolism

140.0

rhoA GTP-Binding Protein/*metabolism

23.0

Fusion Proteins, bcr-abl/*metabolism

38.0

Glutathione Transferase/metabolism

30.0

Mice, Nude

30.0

Cell Differentiation/drug effects

70.0

Cytoplasm/chemistry

21.0

Hematopoietic Stem Cells/cytology/*drug effects

59.0

Microscopy, Fluorescence

40.0

Protein Transport

50.0

Trans-Activators/pharmacology/physiology

2100.0

Recombinant Fusion Proteins/chemistry

22.0

*Gene Expression Profiling

20.0

Protein-Tyrosine Kinase/genetics/physiology

213.0

1-Phosphatidylinositol 3-Kinase/antagonists & inhibitors/metabolism

22.0

Cell Cycle/drug effects

50.0

Cell Survival/drug effects/physiology

44.0

Protein Kinase C/antagonists & inhibitors/metabolism

22.0

Protein-Tyrosine Kinase/antagonists & inhibitors/metabolism

812.0

DNA Primers

140.0

Hydrolysis

30.0

Polymerase Chain Reaction

190.0

Carrier Proteins/genetics/metabolism

31.0

Chelating Agents/pharmacology

22.0

Antigens, CD34/analysis

60.0

Carrier Proteins/*genetics

30.0

Infant, Newborn

20.0

Interleukin-3/*pharmacology

75.0

Prolactin/*pharmacology

1113.0

RNA, Messenger/genetics

80.0

Recombinant Proteins/pharmacology

241.0

src Homology Domains

264.0

Gene Expression/drug effects

70.0

Insulin-Like Growth Factor I/genetics

29.0

Liver/drug effects/metabolism

22.0

RNA, Messenger/genetics/metabolism

30.0

Neoplasm Proteins/metabolism

20.0

Oncogene Proteins, Fusion/metabolism

213.0

Antibodies/pharmacology

41.0

Cell Count

20.0

Cell Division/*drug effects

72.0

Culture Media, Serum-Free

20.0

DNA/biosynthesis

61.0

Drug Synergism

100.0

Indoles/pharmacology

52.0

Mitogen-Activated Protein Kinases/antagonists & inhibitors

35.0

Pertussis Toxin

31.0

Protein Kinase C/antagonists & inhibitors

53.0

Rabbits

110.0

Virulence Factors, Bordetella/pharmacology

52.0

Receptors, Somatotropin/*physiology

562.0

Receptor Cross-Talk/physiology

220.0

Sequence Deletion

190.0

Protein-Tyrosine Kinase/*analysis

26.0

Trans-Activators/*analysis

28.0

Interleukin-6/*physiology

56.0

Biological Transport

30.0

*Endocytosis

21.0

Receptors, Somatotropin/chemistry/genetics/*metabolism

375.0

Recombinant Proteins/chemistry/metabolism

60.0

Signal Transduction/drug effects/*physiology

125.0

Ubiquitins/*metabolism

21.0

MAP Kinase Kinase 1

63.0

MAP Kinase Signaling System/drug effects

44.0

Mitogen-Activated Protein Kinase Kinases/antagonists & inhibitors

24.0

Neoplasm Proteins/*metabolism

40.0

Protein Processing, Post-Translational/*drug effects

611.0

Protein-Serine-Threonine Kinases/antagonists & inhibitors

44.0

Transforming Growth Factor beta/*pharmacology

20.0

1-Phosphatidylinositol 3-Kinase/*metabolism

72.0

Kidney

61.0

Leptin/*pharmacology

310.0

Phosphoproteins/*physiology

22.0

Proto-Oncogene Proteins c-bcl-2/metabolism

20.0

Cell Adhesion Molecules/*metabolism

20.0

Cytoskeletal Proteins/metabolism

41.0

Hematopoietic Stem Cells/*physiology

32.0

Nuclear Proteins/metabolism

50.0

Protein Kinases/metabolism

51.0

Antineoplastic Agents/therapeutic use

20.0

Carrier Proteins/*genetics/metabolism

20.0

Tyrphostins/therapeutic use

2100.0

DNA-Binding Proteins/genetics/physiology

22.0

Carrier Proteins/metabolism

60.0

Cytokines/*metabolism

72.0

Electrophoresis, Polyacrylamide Gel

120.0

Growth Hormone/*metabolism

1121.0

Immunoprecipitation

20.0

RNA/metabolism

20.0

Recombinant Proteins/chemistry

30.0

Breast Neoplasms

31.0

Cell Nucleus/*metabolism

20.0

DNA-Binding Proteins/metabolism/*physiology

43.0

Plasmids

20.0

Trans-Activators/metabolism/*physiology

46.0

Human Growth Hormone/pharmacology

529.0

Lipopolysaccharides/*pharmacology

20.0

RNA, Messenger/biosynthesis

70.0

Transcription, Genetic/*drug effects

41.0

Calcium/*metabolism

30.0

Hematopoiesis/physiology

24.0

Comparative Study

320.0

Consensus Sequence

50.0

Conserved Sequence

40.0

Homeostasis

20.0

Models, Molecular

70.0

Protein-Tyrosine Kinase/*chemistry

315.0

Sequence Alignment

70.0

Protein-Tyrosine Kinase/*immunology

213.0

Binding Sites

230.0

Chimeric Proteins/metabolism

42.0

Mutagenesis

100.0

Oncogene Proteins, Fusion/*metabolism

210.0

Enzyme Inhibitors/*pharmacology

20.0

Leukemia/pathology

39.0

Piperazines/*pharmacology

23.0

Pyrimidines/*pharmacology

34.0

Biological Transport/drug effects

20.0

Cell Nucleus/drug effects/metabolism

23.0

Muscle, Smooth, Vascular/cytology/drug effects/metabolism

228.0

Transduction, Genetic

20.0

Cell Line, Transformed

60.0

Fluorescent Antibody Technique

60.0

Trans-Activators

24.0

Child, Preschool

60.0

Transcription Factors/*genetics

20.0

Interleukin-6/pharmacology

72.0

Interferon-gamma, Recombinant/*pharmacology

53.0

Molecular Weight

100.0

Quinones/pharmacology

42.0

Apoptosis/drug effects/physiology

22.0

Cell Adhesion/drug effects

20.0

Transcription Factors/physiology

31.0

Transcription, Genetic/drug effects/physiology

25.0

1-Phosphatidylinositol 3-Kinase/antagonists & inhibitors

22.0

Animals, Newborn

20.0

Cyclic AMP-Dependent Protein Kinases/antagonists & inhibitors

27.0

DNA-Binding Proteins/genetics/*physiology

20.0

Insulin/biosynthesis

225.0

Receptors, Prolactin/genetics

240.0

Trans-Activators/genetics/*physiology

22.0

Calcium/metabolism

90.0

Gene Expression Regulation, Neoplastic/*drug effects

41.0

Protein-Tyrosine Kinase/genetics

54.0

Sheep

61.0

Interleukin-13/*pharmacology

48.0

Interleukin-4/*pharmacology

83.0

Signal Transduction/*drug effects/physiology

23.0

Trans-Activators/antagonists & inhibitors/*metabolism

28.0

Mice, Inbred C57BL

60.0

Signal Transduction/genetics/*immunology

44.0

Immunosorbent Techniques

93.0

Receptors, Somatotropin/genetics/*metabolism

428.0

Tetradecanoylphorbol Acetate/pharmacology

50.0

DNA/genetics/metabolism

51.0

Interleukin-6/*antagonists & inhibitors/pharmacology

233.0

Mutation/genetics

20.0

Protein-Serine-Threonine Kinases/genetics/metabolism

21.0

Protein-Tyrosine-Phosphatase/antagonists & inhibitors/metabolism

214.0

*Receptor Cross-Talk

214.0

rhoA GTP-Binding Protein/metabolism

22.0

Gene Expression Regulation, Enzymologic/drug effects/*physiology

27.0

Genes, ras

41.0

Isoenzymes/genetics/*metabolism

22.0

Mitogen-Activated Protein Kinase Kinases/metabolism

21.0

*Promoter Regions (Genetics)

40.0

Cattle

80.0

Lymphokines/*pharmacology

20.0

Receptor Protein-Tyrosine Kinases/metabolism

20.0

Lymphokines/pharmacology

42.0

Peptides/*pharmacology

52.0

Carrier Proteins/chemistry/genetics/*metabolism

32.0

Receptor, Insulin/metabolism

67.0

Binding, Competitive

40.0

Protein-Tyrosine Kinase/genetics/metabolism

34.0

Cell Division/physiology

60.0

Crystallography, X-Ray

20.0

Gene Expression Regulation

180.0

Human Growth Hormone/chemistry/*physiology

2100.0

Protein Processing, Post-Translational

111.0

Phenylalanine

311.0

Receptors, Somatotropin/chemistry/genetics/*physiology

266.0

Recombinant Proteins/metabolism/pharmacology

43.0

Enzyme Inhibitors/metabolism

31.0

Granulocyte-Macrophage Colony-Stimulating Factor/pharmacology

82.0

Androstadienes/pharmacology

41.0

Densitometry

21.0

Signal Transduction/drug effects/genetics

38.0

Transfection/genetics

21.0

Apoptosis/*drug effects

20.0

Cell Survival/drug effects

70.0

*Proto-Oncogene Proteins c-bcl-2

20.0

Stem Cell Factor/*pharmacology

46.0

Gene Expression Regulation/drug effects

80.0

Interleukin-2/pharmacology

61.0

Receptors, Erythropoietin/genetics/metabolism

218.0

Exons

30.0

Introns

30.0

Luciferases/genetics/metabolism

20.0

Phylogeny

30.0

Promoter Regions (Genetics)/*genetics

20.0

Protein-Tyrosine Kinase/*genetics

62.0

Regulatory Sequences, Nucleic Acid

40.0

Sequence Analysis, DNA

40.0

Immunohistochemistry

90.0

Maleimides/pharmacology

22.0

Proteins/physiology

21.0

Infant

40.0

Depression, Chemical

21.0

Interleukin-6/metabolism

20.0

Protein-Tyrosine Kinase/*antagonists & inhibitors

95.0

Signal Transduction/drug effects/immunology

24.0

Peptide Mapping

40.0

Receptors, Cytokine/physiology

311.0

Receptors, Prolactin/physiology

222.0

Cell Culture Techniques

20.0

Eosinophils/*immunology

35.0

DNA, Complementary

120.0

CHO Cells

241.0

Enhancer Elements (Genetics)

20.0

Leukocyte Count

20.0

Carcinoma, Hepatocellular/metabolism

22.0

Insulin/*pharmacology

62.0

Insulin-Like Growth Factor I/pharmacology

21.0

*Transcription, Genetic

20.0

DNA-Binding Proteins/biosynthesis

22.0

Proto-Oncogene Proteins c-fos/metabolism

21.0

Receptors, Somatotropin/chemistry/*metabolism

350.0

Trans-Activators/biosynthesis

25.0

Dexamethasone/pharmacology

30.0

Growth Hormone/pharmacology

411.0

Receptors, Interleukin-6/genetics/*metabolism

266.0

Stimulation, Chemical

40.0

Cricetulus

20.0

Macromolecular Substances

180.0

Recombinant Fusion Proteins/physiology

31.0

*Cell Transformation, Neoplastic

30.0

Cytoplasm/metabolism

60.0

Genes, fos

65.0

Embryo

20.0

Insulin-Like Growth Factor I/*pharmacology

21.0

Cell Adhesion

60.0

Protein-Tyrosine Kinase/antagonists & inhibitors/metabolism/*physiology

325.0

Tissue Distribution

40.0

Receptors, Interferon/metabolism

512.0

U937 Cells

30.0

1-Phosphatidylinositol 3-Kinase/physiology

21.0

Interferon-gamma, Recombinant/pharmacology

42.0

*Protein Biosynthesis

40.0

Models, Genetic

20.0

Cytokines/metabolism

30.0

DNA-Binding Proteins/chemistry/*metabolism

31.0

Interleukin-3/metabolism

26.0

Transcription Factors/chemistry/*metabolism

32.0

*Genes, myc

31.0

Interleukin-2/*pharmacology

51.0

Thrombin/*pharmacology

32.0

Up-Regulation/drug effects

20.0

Hodgkin Disease/*genetics

211.0

Nucleic Acid Hybridization

20.0

*Saccharomyces cerevisiae Proteins

20.0

Signal Transduction/genetics

20.0

DNA-Binding Proteins/chemistry/genetics/metabolism

26.0

Protein-Tyrosine Kinase/chemistry/metabolism

212.0

Protein Kinase C/*metabolism

20.0

Mitogen-Activated Protein Kinases/genetics/*metabolism

24.0

Angiotensin II/*physiology

411.0

DNA-Binding Proteins/*biosynthesis

21.0

Enzyme Induction

50.0

NADPH Oxidase/*physiology

228.0

Protein-Tyrosine Kinase/*biosynthesis

520.0

Reactive Oxygen Species/metabolism

51.0

Trans-Activators/*biosynthesis

23.0

Receptors, Interleukin/*metabolism

515.0

Tyrosine/genetics/metabolism

210.0

DNA-Binding Proteins/biosynthesis/*metabolism

23.0

Trans-Activators/biosynthesis/*metabolism

213.0

Lymphocyte Activation/*drug effects

20.0

Carcinoma, Hepatocellular

30.0

*Growth Inhibitors

23.0

*Interleukin-6

51.0

*Lymphokines

24.0

Hypophysectomy

35.0

Proteins/*metabolism

151.0

Rats, Inbred F344

30.0

Receptors, Somatotropin/drug effects/*physiology

266.0

Liver/*metabolism

40.0

Carrier Proteins/genetics

20.0

Chromosome Mapping

60.0

Point Mutation

50.0

Cytokines/physiology

42.0

Erythroid Progenitor Cells/*cytology

210.0

Erythropoietin/physiology

216.0

Alleles

20.0

*Gene Expression Regulation, Developmental

20.0

Phenotype

30.0

Species Specificity

30.0

Leptin/*physiology

218.0

Proteins/genetics/*physiology

32.0

Enzyme Activation/genetics

33.0

*Genes, fos

23.0

Protein-Tyrosine Kinase/analysis/*metabolism

228.0

Receptors, Somatotropin/*metabolism

420.0

Pedigree

20.0

Receptors, Erythropoietin/*genetics

27.0

Prolactin/*metabolism

35.0

Proteins/genetics/metabolism

21.0

*Trans-Activators

20.0

Tumor Necrosis Factor-alpha/*pharmacology

20.0

DNA, Complementary/genetics

60.0

Diagnosis, Differential

20.0

*src Homology Domains

63.0

Cell Differentiation/drug effects/physiology

22.0

Granulocyte Colony-Stimulating Factor/*pharmacology

43.0

Receptors, Granulocyte Colony-Stimulating Factor/*physiology

233.0

Enzyme Activation/immunology

43.0

*Mitogen-Activated Protein Kinases

72.0

*Apoptosis

40.0

Computer Simulation

20.0

Drug Design

20.0

Quinazolines/*pharmacology

22.0

Age Factors

20.0

Ca(2+)-Calmodulin Dependent Protein Kinase/metabolism

144.0

Granulocyte-Macrophage Colony-Stimulating Factor/metabolism

23.0

Interleukin-2/metabolism

21.0

Mitogen-Activated Protein Kinase 1

43.0

Protein Biosynthesis

30.0

Transcription Factors/biosynthesis

33.0

Cyclins/genetics/metabolism

23.0

Gene Expression Regulation, Neoplastic

50.0

Neutrophils/*enzymology

21.0

Phosphotyrosine/blood

333.0

Molecular Structure

20.0

Recombinant Fusion Proteins/genetics

21.0

Proteins/*physiology

42.0

Proto-Oncogene Proteins/*physiology

20.0

Receptors, Erythropoietin/metabolism

722.0

*Ubiquitin-Protein Ligases

50.0

Proteins/genetics/*metabolism

30.0

Receptors, Granulocyte Colony-Stimulating Factor/*genetics

233.0

Receptors, Interleukin/chemistry/*physiology

266.0

Antineoplastic Agents/*pharmacology/therapeutic use

22.0

Granulocyte-Macrophage Colony-Stimulating Factor/physiology

27.0

src-Family Kinases/*antagonists & inhibitors

212.0

Gene Expression Regulation, Enzymologic

30.0

Protein Kinase C/metabolism

40.0

Stress, Mechanical

20.0

Granulocyte Colony-Stimulating Factor/*metabolism

222.0

Hematopoiesis

41.0

Proto-Oncogene Proteins/*metabolism

100.0

Genes, fos/genetics

36.0

Granulocyte-Macrophage Colony-Stimulating Factor/*physiology

316.0

Signal Transduction/*immunology

61.0

DNA Primers/genetics

30.0

Tumor Necrosis Factor-alpha/pharmacology

40.0

Thrombopoietin/*metabolism

27.0

Glutathione Transferase/genetics

20.0

Receptors, Somatotropin/genetics/metabolism

350.0

Aorta

21.0

Histocompatibility Antigens Class I/biosynthesis

24.0

Carrier Proteins/*pharmacology

24.0

Gene Expression Regulation, Leukemic

22.0

Neoplasm Proteins/physiology

23.0

Tumor Cells, Cultured/drug effects

30.0

Genes, MHC Class II

20.0

Antiviral Agents/*pharmacology

21.0

HL-60 Cells

50.0

Suppression, Genetic

23.0

Lymphocyte Activation/drug effects

20.0

In Vitro

100.0

Cell Membrane/chemistry

21.0

Protein Conformation

90.0

Human Growth Hormone/*metabolism

215.0

Pregnancy

20.0

Mammals

30.0

Receptors, Cytokine/*physiology

415.0

Binding Sites/genetics

20.0

Human Growth Hormone/genetics/*metabolism

266.0

Interferon-alpha/*pharmacology

53.0

Lymphocyte Activation

30.0

Recombinant Proteins/biosynthesis

30.0

Recombinant Fusion Proteins/chemistry/metabolism

21.0

Interleukin-13/pharmacology/*physiology

228.0

Mice, Mutant Strains

20.0

Protein-Tyrosine-Phosphatase/genetics/*metabolism

36.0

Clone Cells

20.0

Protein-Tyrosine Kinase/metabolism/*physiology

311.0

Proteins/metabolism/*physiology

24.0

Receptors, Interleukin/biosynthesis

318.0

Half-Life

20.0

Ca(2+)-Calmodulin Dependent Protein Kinase/*metabolism

72.0

Antigens, CD/chemistry/*physiology

214.0

Chimeric Proteins/chemistry/metabolism

35.0

Interleukin-6/pharmacology/*physiology

218.0

Liver Neoplasms

20.0

Membrane Glycoproteins/chemistry/*physiology

213.0

Erythropoietin/biosynthesis/genetics/*physiology

2100.0

Human Growth Hormone/pharmacology/*physiology

266.0

Receptor, Epidermal Growth Factor/*metabolism

60.0

Luciferases/genetics

41.0

Peptide Fragments/chemistry/immunology

23.0

Recombinant Fusion Proteins/biosynthesis

40.0

DNA-Binding Proteins/*genetics/metabolism

20.0

Interleukin-6/*pharmacology

62.0

Trans-Activators/*genetics/metabolism

32.0

Eosinophils/physiology

215.0

*Hematopoiesis

31.0

Interleukin-5/*physiology

333.0

Cell Differentiation/physiology

30.0

Isomerism

20.0

Oxidation-Reduction

30.0

Transcription Factors/genetics

20.0

*Trans-Activation (Genetics)

40.0

B-Lymphocytes/*physiology

21.0

Antigens, CD/*metabolism

40.0

Membrane Glycoproteins/*metabolism

30.0

Receptors, Interleukin/*physiology

416.0

*Tyrphostins

35.0

Erythropoietin/metabolism/*pharmacology

266.0

Child

50.0

Antineoplastic Agents/*therapeutic use

20.0

Blotting, Western/methods

21.0

Antibodies, Monoclonal/immunology

20.0

Lymphocyte Activation/*physiology

22.0

Gene Library

50.0

Solubility

20.0

Interferon Type II/*antagonists & inhibitors/pharmacology

266.0

GTP-Binding Proteins/*metabolism

20.0

Gene Expression Regulation/*drug effects

60.0

Growth Inhibitors/pharmacology

32.0

Umbilical Veins

20.0

Interleukin-5/*metabolism

225.0

Jurkat Cells

20.0

Receptors, Prolactin/metabolism

212.0

Cycloheximide/pharmacology

20.0

Liver Neoplasms, Experimental/metabolism

210.0

Protein Synthesis Inhibitors/pharmacology

20.0

Baculoviridae/genetics

31.0

Protein-Tyrosine Kinase/chemistry/genetics/*metabolism

28.0

Receptors, Granulocyte-Macrophage Colony-Stimulating Factor/physiology

250.0

Receptor Protein-Tyrosine Kinases/*metabolism

41.0

Chickens

20.0

Receptors, Granulocyte Colony-Stimulating Factor/metabolism

216.0

*Gene Expression Regulation

60.0

Interferon Type II/*physiology

57.0

Proto-Oncogene Protein p21(ras)/metabolism

33.0

Recombinant Proteins/chemistry/genetics/metabolism

30.0

Spodoptera

41.0

Neutrophils/*metabolism

31.0

Protein-Tyrosine Kinase/*chemistry/genetics/*metabolism

211.0

Tyrosine/chemistry

64.0

Receptors, Cell Surface/*metabolism

20.0

Receptors, Prolactin/genetics/*metabolism

350.0

Staurosporine/pharmacology

42.0

Chimeric Proteins

22.0

Biopolymers

21.0

Translocation, Genetic

20.0

Proto-Oncogene Protein c-kit/*metabolism

36.0

Trans-Activators/chemistry/*metabolism

23.0

Alternative Splicing

20.0

Antibodies/immunology

20.0

Erythropoietin, Recombinant/*pharmacology

28.0

Receptors, Angiotensin/antagonists & inhibitors

24.0

Models, Structural

21.0

Cyclic AMP/metabolism

20.0

Growth Hormone/metabolism

24.0

Protein-Serine-Threonine Kinases/*metabolism

30.0

Serine/chemistry

21.0

1-Phosphatidylinositol 3-Kinase

85.0

Interferons/*pharmacology

22.0

Phosphotransferases (Alcohol Group Acceptor)/metabolism

45.0

Receptor, IGF Type 1/metabolism

26.0

Antibodies, Monoclonal/pharmacology

20.0

Antigens, CD/immunology

20.0

Monocytes/*metabolism

30.0

Receptors, IgG/*biosynthesis/genetics

250.0

*Mutation

20.0

Rats, Inbred Lew

20.0

Receptors, Somatotropin/genetics

214.0

Culture Media

20.0

Fibrosarcoma

36.0

Recombinant Proteins/biosynthesis/pharmacology

26.0

Cell Nucleus/*enzymology

25.0

Mitogen-Activated Protein Kinase Kinases

25.0

Nitric Oxide/metabolism

31.0

Receptors, Prolactin/genetics/metabolism

240.0

Recombinant Proteins/genetics/metabolism

20.0

Epidermal Growth Factor/pharmacology

50.0

Interferon-beta/*pharmacology

46.0

*Mitogen-Activated Protein Kinase Kinases

22.0

Proto-Oncogene Proteins c-raf

32.0

Proto-Oncogene Proteins c-fos/genetics

23.0

*Cell Cycle Proteins

60.0

Phosphotransferases (Alcohol Group Acceptor)/*metabolism

44.0

Proline

35.0

Protein-Tyrosine Kinase/*genetics/metabolism

48.0

Trans-Activators/*genetics

20.0

Receptors, Interleukin-3/*metabolism

228.0

Receptors, Interleukin-6

44.0

Cell Adhesion Molecules/isolation & purification/*metabolism

250.0

Protein-Tyrosine Kinase/isolation & purification/*metabolism

735.0

Proto-Oncogene Proteins/genetics/metabolism

21.0

Receptors, Interleukin-4

710.0

Recombinant Proteins/biosynthesis/isolation & purification/metabolism

23.0

1-Phosphatidylinositol 3-Kinase/antagonists & inhibitors/*metabolism

23.0

Enzyme Activation/physiology

31.0

Thrombopoietin/*pharmacology

1111.0

Interleukin-4/*physiology

24.0

T-Lymphocytes

31.0

Mitosis/drug effects

21.0

Protein Kinases/*metabolism

20.0

Glycosylation

20.0

Adipocytes/drug effects/*metabolism

215.0

Cytokines/*pharmacology

92.0

Receptors, Interleukin-3/*physiology

2100.0

Lipids/biosynthesis

210.0

Luciferases/biosynthesis

33.0

Growth Hormone/*metabolism/pharmacology

250.0

Receptors, Interleukin-7

211.0

Proteins/chemistry

24.0

Son of Sevenless Proteins

35.0

Receptor, Epidermal Growth Factor/metabolism

40.0

Peptides/*genetics

22.0

Cell Transformation, Neoplastic

20.0

B-Lymphocytes/drug effects/immunology/*physiology

240.0

Thymidine/metabolism

20.0

Hybrid Cells

20.0

Proto-Oncogene Proteins/antagonists & inhibitors

317.0

DNA-Binding Proteins/isolation & purification/*metabolism

34.0

Phosphoproteins/isolation & purification/*metabolism

412.0

Proteins/isolation & purification/*metabolism

39.0

Trans-Activators/isolation & purification/*metabolism

215.0

Interleukin-12/*pharmacology

36.0

Serine/metabolism

20.0

*Protein Processing, Post-Translational/drug effects

211.0

Sequence Homology, Nucleic Acid

50.0

Blood Platelets/drug effects/*enzymology

215.0

Platelet Activation/*drug effects

23.0

Platelet Aggregation/drug effects

20.0

Thrombin/pharmacology

20.0

Culture Media, Serum-Free/pharmacology

21.0

Growth Hormone/metabolism/*pharmacology

250.0

Cross-Linking Reagents

20.0

Oligonucleotide Probes

30.0

Interferon-alpha/pharmacology

33.0

Phosphoproteins/isolation & purification/metabolism

720.0

Hematopoietic Stem Cells

23.0

Oligodeoxyribonucleotides

80.0

Oligodeoxyribonucleotides/chemistry

20.0

Cytoplasm

23.0

HIV-1/*physiology

20.0

Aspirin/pharmacology

23.0

Blood Platelets/*drug effects/metabolism

25.0

Platelet Aggregation Inhibitors/pharmacology

23.0

*Protein Processing, Post-Translational

20.0

Cell Nucleus/physiology

22.0

Phosphoproteins/analysis

25.0

*Antigens, CD

20.0

Receptors, Somatotropin/*chemistry/genetics/*physiology

2100.0

Membrane Proteins/metabolism

20.0

Angiotensin II/*pharmacology

43.0

Cytosol/metabolism

20.0

Interleukin-11/*pharmacology

212.0

Intercellular Adhesion Molecule-1/metabolism

21.0

Catalysis

40.0

Receptors, Interleukin-2/*metabolism

22.0

T-Lymphocytes/*metabolism

20.0

Phosphotyrosine

249.0

*Tyrosine/analogs & derivatives/metabolism

266.0

Recombinant Proteins/biosynthesis/metabolism/pharmacology

433.0

Cercopithecus aethiops

50.0

*Protein Kinase Inhibitors

23.0

Staurosporine

33.0

Interleukin-4/pharmacology

30.0

Tyrosine/analogs & derivatives/analysis

410.0

Tyrosine/analogs & derivatives/metabolism

108.0

Interleukin-3/*physiology

320.0

Oligonucleotides, Antisense/pharmacology

31.0

Angiotensin II/*metabolism

24.0

Epidermal Growth Factor/metabolism

20.0

Colony-Forming Units Assay

30.0

Erythropoietin, Recombinant/pharmacology

225.0

Aurintricarboxylic Acid/*pharmacology

222.0

Linkage (Genetics)

20.0

Tyrosine/*analogs & derivatives/metabolism

23.0

Transcription, Genetic/drug effects

40.0

Stem Cell Factor

33.0

Alkaloids/pharmacology

21.0

Antibodies, Monoclonal

30.0

Receptors, Somatotropin/analysis/genetics/*metabolism

2100.0

Protein Binding/drug effects

20.0

Receptors, Erythropoietin/biosynthesis/*physiology

240.0

Chromosome Aberrations

20.0

Thermodynamics

20.0

Cell Membrane/*metabolism

20.0

Tyrosine/*analogs & derivatives/analysis/metabolism

333.0

Enzyme Induction/drug effects/genetics

228.0

Protein Transport/drug effects

23.0

DNA-Binding Proteins/biosynthesis/genetics

22.0

Trans-Activators/biosynthesis/genetics

25.0

Receptors, Cytokine/chemistry/*metabolism

233.0

Muscle, Smooth, Vascular/*cytology

29.0

rac1 GTP-Binding Protein/metabolism

22.0

Mitogen-Activated Protein Kinase 1/*metabolism

21.0

Protein-Tyrosine-Phosphatase/genetics/*physiology

325.0

Epithelial Cells/cytology

22.0

Karyotyping

20.0

MAP Kinase Signaling System/*drug effects

25.0

Phosphoserine/metabolism

22.0

Aorta/cytology

22.0

Electroporation

23.0

Vasoconstrictor Agents/*pharmacology

25.0

Mitogen-Activated Protein Kinases/antagonists & inhibitors/*metabolism

22.0

Acetophenones/pharmacology

313.0

Caspases/metabolism

20.0

*Drug Design

22.0

Enzyme-Linked Immunosorbent Assay

20.0

Electrophoretic Mobility Shift Assay

20.0

Active Transport, Cell Nucleus

20.0

Receptor, erbB-2/metabolism

21.0

Collagen Type II/*genetics

29.0

Guanosine Triphosphate/metabolism

20.0