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Gene Symbol
Gene NameAliasesPrevious_Symbol

ERBB2

v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)NEU, HER-2v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)


Gene ERBB2 gene interaction
View Neighborhood Gene

Result number fewer <<<< << < ALL > >> >>> more

MeSH term
FrequencyCondition_Probility

Female

2980.0

Humans

6370.0

Pregnancy

100.0

Randomized Controlled Trials

30.0

Cell Culture Techniques

20.0

Cell Differentiation/*physiology

20.0

Adult

810.0

Child

150.0

Male

820.0

Cluster Analysis

42.0

Genes, erbB-2

2733.0

*Genetic Markers

41.0

In Situ Hybridization, Fluorescence

311.0

Nucleic Acid Hybridization/methods

22.0

Prognosis

570.0

Research Support, Non-U.S. Gov't

4200.0

Tumor Markers, Biological/genetics/metabolism

212.0

1-Phosphatidylinositol 3-Kinase/metabolism

91.0

Breast Neoplasms/metabolism

54.0

Enzyme Activation

280.0

*Gene Expression Regulation

50.0

Mitogen-Activated Protein Kinases/metabolism

212.0

Neuregulin-1/*physiology

222.0

Receptor, erbB-2/*metabolism

6039.0

Research Support, U.S. Gov't, P.H.S.

1990.0

Tumor Cells, Cultured

1630.0

Adenocarcinoma/*metabolism

22.0

Animals

2040.0

Blotting, Western

400.0

Breast Neoplasms/*metabolism

196.0

*Drug Resistance, Neoplasm

42.0

Immunoenzyme Techniques

170.0

Precipitin Tests

220.0

Rats

370.0

Receptor, erbB-2/*immunology

847.0

Research Support, U.S. Gov't, Non-P.H.S.

620.0

Transfection

650.0

Aged

760.0

Breast Neoplasms/*metabolism/pathology

42.0

Comparative Study

770.0

Disease-Free Survival

121.0

Lymph Nodes/pathology

20.0

Lymphatic Metastasis

100.0

Middle Aged

980.0

Vascular Endothelial Growth Factor A

60.0

Administration, Oral

20.0

Aged, 80 and over

360.0

Disease Progression

110.0

Receptor, Epidermal Growth Factor/metabolism

315.0

Receptor, erbB-2/metabolism

4125.0

Receptors, Estrogen/*metabolism

41.0

Receptors, Progesterone/metabolism

73.0

Cell Adhesion

70.0

Cell Division

260.0

DNA Primers/chemistry

40.0

Fibroblasts/metabolism

40.0

Immunoblotting

170.0

Mutagenesis, Site-Directed

80.0

Phosphorylation

941.0

Plasmids

30.0

Polymerase Chain Reaction

220.0

Receptor, Epidermal Growth Factor/genetics/*physiology

26.0

Receptor, erbB-2/genetics/*physiology

457.0

Retroviridae/genetics

71.0

Signal Transduction

520.0

Tyrosine/metabolism

262.0

*Chromosome Mapping

80.0

Chromosomes, Human, Pair 17/*genetics

63.0

Genes, erbB-2/genetics

830.0

Neoplasm Invasiveness/genetics

36.0

Neoplasm Staging

241.0

Survival Analysis

130.0

Amino Acid Sequence

440.0

Epithelium/metabolism

51.0

Ligands

481.0

Models, Biological

70.0

Molecular Sequence Data

610.0

Mucins/genetics/*metabolism

25.0

Sequence Homology, Amino Acid

190.0

Chromatography, Liquid

21.0

Sensitivity and Specificity

90.0

Antigens, CD44/metabolism

22.0

Cell Division/drug effects

391.0

Gene Expression Regulation/drug effects

30.0

Phosphorylation/drug effects

151.0

Receptor, Epidermal Growth Factor/*physiology

53.0

1-Phosphatidylinositol 3-Kinase/*metabolism

41.0

Cell Cycle Proteins/metabolism

41.0

Cyclins/metabolism

30.0

Enzyme Inhibitors/pharmacology

200.0

Epidermal Growth Factor/pharmacology

182.0

Flow Cytometry

140.0

Mitogen-Activated Protein Kinases/*metabolism

40.0

Neuregulin-1/pharmacology

746.0

Signal Transduction/drug effects

81.0

Time Factors

280.0

p38 Mitogen-Activated Protein Kinases

60.0

Mice

1130.0

Mice, Mutant Strains

30.0

*Mutation

40.0

Biopsy

60.0

English Abstract

170.0

Multigene Family

40.0

*Oligonucleotide Array Sequence Analysis

73.0

Tumor Markers, Biological

92.0

Antibodies, Monoclonal/*therapeutic use

61.0

Bacteriophages/genetics

28.0

Cloning, Molecular

160.0

Endocytosis

51.0

Antineoplastic Agents, Phytogenic/*pharmacology

31.0

*Apoptosis

50.0

Breast Neoplasms/metabolism/pathology

25.0

CDC2 Protein Kinase/*metabolism

32.0

Cells, Cultured

350.0

Cyclin B/metabolism

33.0

DNA Fragmentation

30.0

Drug Resistance, Neoplasm

81.0

In Situ Nick-End Labeling

20.0

Mitosis

40.0

Paclitaxel/*pharmacology

57.0

Tyrosine/*metabolism

41.0

Cell Line

650.0

Dogs

60.0

Protein Binding

320.0

Antibodies, Monoclonal/pharmacology

60.0

Antineoplastic Agents/*pharmacology

90.0

Epidermal Growth Factor/*pharmacology

60.0

G1 Phase/drug effects

21.0

Growth Substances/pharmacology

31.0

*Intercellular Signaling Peptides and Proteins

81.0

*Protein-Serine-Threonine Kinases

182.0

Proto-Oncogene Proteins/metabolism

201.0

Pyrimidines/*pharmacology

23.0

Pyrroles/*pharmacology

24.0

Receptor, Epidermal Growth Factor/*antagonists & inhibitors

86.0

Receptor, erbB-2/*antagonists & inhibitors

640.0

Signal Transduction/drug effects/physiology

31.0

Substrate Specificity

40.0

Dimerization

271.0

Intercellular Signaling Peptides and Proteins/pharmacology

27.0

Receptor, Epidermal Growth Factor/*metabolism

374.0

Receptor, erbB-2/*physiology

936.0

Receptor, erbB-3/*physiology

240.0

Blotting, Northern

190.0

*DNA-Binding Proteins

30.0

*Gene Expression Regulation, Neoplastic

191.0

Promoter Regions (Genetics)

100.0

Proto-Oncogene Proteins/*biosynthesis/genetics

33.0

Reverse Transcriptase Polymerase Chain Reaction

430.0

Transcription, Genetic

130.0

Drug Design

30.0

Kinetics

210.0

Models, Molecular

130.0

Protein Conformation

90.0

Receptor, erbB-2/chemistry/metabolism

266.0

Receptor, erbB-3/chemistry/metabolism

2100.0

Immunohistochemistry/methods

71.0

Neoplasm Proteins/*analysis

20.0

Pedigree

30.0

Proportional Hazards Models

71.0

Receptor, erbB-2/*analysis

1113.0

Amino Acid Motifs

40.0

Amino Acids/chemistry

43.0

COS Cells

120.0

Glutamic Acid/chemistry

38.0

Mutation

200.0

Protein Structure, Tertiary

180.0

Trans-Activation (Genetics)

50.0

Valine/chemistry

29.0

Breast Neoplasms/genetics

52.0

Doxorubicin/pharmacology

41.0

Gene Amplification

385.0

*Genes, erbB-2

4350.0

Mice, Knockout

70.0

Receptor, Epidermal Growth Factor/genetics

119.0

Gene Dosage

143.0

Gene Expression Profiling

111.0

Oligonucleotide Array Sequence Analysis

171.0

Stomach Neoplasms/*genetics/metabolism

27.0

Cell Transformation, Neoplastic

71.0

*Gene Amplification

328.0

Gene Expression Regulation, Neoplastic

381.0

*Neoplasm Invasiveness

34.0

Receptor, Epidermal Growth Factor

20.0

Receptor, erbB-2/*biosynthesis

1734.0

Antibiotics, Antineoplastic/*pharmacology

43.0

Clinical Trials

80.0

Growth Inhibitors/pharmacology

21.0

Heat-Shock Proteins 90/*antagonists & inhibitors

541.0

Protein Kinases/metabolism

40.0

Quinones/*pharmacology

516.0

Receptors, Growth Factor/*metabolism

32.0

Transcription Factors/metabolism

60.0

Gene Expression

250.0

Receptor, erbB-2/genetics/metabolism

533.0

Chromosomes, Human, Pair 17/genetics

74.0

RNA, Messenger/biosynthesis/genetics

40.0

Up-Regulation

110.0

3T3 Cells

160.0

Antineoplastic Combined Chemotherapy Protocols/*pharmacology

36.0

Breast Neoplasms/drug therapy/metabolism

333.0

Cell Survival/drug effects

80.0

Drug Synergism

90.0

*Proto-Oncogene Proteins

80.0

Breast Neoplasms/*pathology

94.0

Cell Cycle

100.0

Phenotype

120.0

Immunohistochemistry

610.0

Receptor, erbB-3/*metabolism

628.0

Heat-Shock Proteins 90/metabolism

26.0

Lung Neoplasms/genetics/*metabolism

211.0

Mitogen-Activated Protein Kinase 1/metabolism

61.0

Protein-Serine-Threonine Kinases/metabolism

40.0

RNA, Messenger/metabolism

200.0

Receptor, Epidermal Growth Factor/genetics/*metabolism

106.0

Receptor, erbB-2/genetics/*metabolism

1442.0

Tumor Cells, Cultured/drug effects

71.0

Antibiotics, Antineoplastic/*therapeutic use

28.0

Protein-Tyrosine Kinase/antagonists & inhibitors

20.0

Antineoplastic Combined Chemotherapy Protocols/*therapeutic use

61.0

Breast Neoplasms/*drug therapy/metabolism/pathology

428.0

Collagen

31.0

Cyclophosphamide/administration & dosage

31.0

Drug Screening Assays, Antitumor

72.0

Epirubicin/administration & dosage

25.0

Gels

22.0

Predictive Value of Tests

110.0

*Taxoids

23.0

Tumor Markers, Biological/metabolism

41.0

Adolescent

140.0

Neoplasm Metastasis

181.0

Antineoplastic Agents/*therapeutic use

51.0

Drug Therapy, Combination

20.0

Estrogen Antagonists/*therapeutic use

315.0

Tamoxifen/*therapeutic use

67.0

Antigens, CD44/*metabolism

21.0

Microscopy, Confocal

70.0

Gene Expression Regulation, Neoplastic/*physiology

42.0

Metaplasia

22.0

Receptor, Epidermal Growth Factor/analysis

63.0

Receptor, erbB-3/*analysis

240.0

Signal Transduction/physiology

101.0

Child, Preschool

80.0

Infant

40.0

Mice, Nude

180.0

Neoplasm Transplantation

151.0

Receptor, erbB-2/*genetics

1848.0

Enzyme Inhibitors/*chemical synthesis/pharmacology

316.0

Proto-Oncogene Proteins/*antagonists & inhibitors

28.0

Structure-Activity Relationship

100.0

Cercopithecus aethiops

30.0

Neuregulins/*metabolism

375.0

Proteins/genetics/*metabolism

20.0

Receptor, erbB-3/genetics/*metabolism

266.0

*Chromosome Aberrations

91.0

Dogs/*genetics

24.0

Cell Differentiation

50.0

Signal Transduction/*genetics

43.0

Apoptosis/physiology

20.0

Cell Movement/*physiology

31.0

Cell Survival/*physiology

23.0

Receptor Protein-Tyrosine Kinases/metabolism

41.0

Down-Regulation

180.0

RNA, Messenger/analysis

120.0

Receptor, Epidermal Growth Factor/analysis/*genetics

29.0

Binding, Competitive

70.0

Dose-Response Relationship, Drug

150.0

Enzyme-Linked Immunosorbent Assay

60.0

Gene Library

20.0

Glutathione Transferase/metabolism

20.0

Recombinant Fusion Proteins/metabolism

50.0

src Homology Domains

50.0

Adenocarcinoma/genetics/metabolism/pathology

26.0

Antibodies/immunology

41.0

Breast Neoplasms/genetics/metabolism/pathology

310.0

*Cell Movement

21.0

Apoptosis/*drug effects

40.0

Breast Neoplasms/pathology

65.0

Enzyme Inhibitors/*pharmacology

91.0

Gene Expression Regulation

120.0

Heat-Shock Proteins 90/*metabolism

312.0

Mice, Inbred BALB C

50.0

Breast Neoplasms

124.0

Cell Membrane/metabolism

60.0

Cytosol/metabolism

20.0

Protein Transport

20.0

Recombinant Proteins/metabolism

80.0

Breast Neoplasms/genetics/metabolism

36.0

*Gene Dosage

44.0

*Gene Expression

80.0

Genes, erbB-2/*genetics

1437.0

Androstadienes/pharmacology

41.0

Binding Sites

200.0

Neuregulin-1/metabolism

430.0

Oncogene Proteins v-erbB/metabolism

555.0

Phosphoproteins/genetics/*metabolism

21.0

Proto-Oncogene Proteins/*metabolism

131.0

Breast Neoplasms/diagnosis/genetics/*metabolism

240.0

Cyclin D1/biosynthesis/genetics

315.0

Estrogen Receptor alpha

93.0

Protein Biosynthesis

40.0

Proteins/genetics

30.0

Proto-Oncogene Proteins c-myc/biosynthesis/genetics

211.0

RNA, Neoplasm/biosynthesis

21.0

Receptor, erbB-2/biosynthesis/genetics

840.0

Receptors, Estrogen/*biosynthesis/genetics

233.0

Cycloheximide/pharmacology

30.0

*Genes, erbB

545.0

Insulin/*pharmacology

20.0

MAP Kinase Signaling System

41.0

Neuregulin-1/physiology

250.0

*Trans-Activation (Genetics)

40.0

Tumor Necrosis Factor-alpha/*pharmacology

30.0

Genes, erbB

675.0

*Receptor, erbB-2

3100.0

Receptor, erbB-3

2731.0

Alternative Splicing

30.0

DNA, Complementary/genetics

30.0

Peptide Mapping

20.0

Protein Isoforms

71.0

Cell Cycle/drug effects

71.0

Receptor, erbB-2/*biosynthesis/metabolism

2100.0

Xenograft Model Antitumor Assays

73.0

DNA-Binding Proteins/biosynthesis/genetics

22.0

Pancreatic Neoplasms/genetics/*metabolism/pathology

216.0

Protein p53/biosynthesis/genetics

48.0

Antibiotics, Antineoplastic/pharmacology

33.0

Cell Survival

20.0

Chromones/pharmacology

52.0

Cyclin E/metabolism

21.0

Genes, Dominant

30.0

Morpholines/pharmacology

52.0

Sirolimus/pharmacology

22.0

Neoplasms, Experimental/*drug therapy/pathology

222.0

Quinazolines/*pharmacology/therapeutic use

233.0

Cell Division/*drug effects

31.0

Plasmids/genetics

40.0

Cell Membrane/*metabolism

31.0

DNA Mutational Analysis

30.0

Genetic Vectors

60.0

Receptor, Epidermal Growth Factor/*chemistry

213.0

Antineoplastic Agents/pharmacology

91.0

Butadienes/pharmacology

23.0

Cell Division/physiology

70.0

MAP Kinase Signaling System/*physiology

33.0

Microscopy, Fluorescence

80.0

Mitogen-Activated Protein Kinase 7

213.0

Nitriles/pharmacology

21.0

Phthalimides/pharmacology

2100.0

Receptor, Epidermal Growth Factor/antagonists & inhibitors/*metabolism

26.0

Recombinant Fusion Proteins/genetics/metabolism

20.0

CHO Cells

100.0

Cell Line, Tumor

341.0

Hamsters

150.0

In Vitro

100.0

Recombinant Proteins/chemistry/genetics/metabolism

20.0

Breast Neoplasms/*genetics

273.0

Models, Genetic

50.0

Receptors, Estrogen/metabolism

103.0

Age Factors

40.0

Down-Regulation/genetics

23.0

*Gene Expression Profiling

40.0

*Intracellular Signaling Peptides and Proteins

30.0

*Tumor Suppressor Proteins

50.0

Genome, Human

20.0

Antineoplastic Agents/*pharmacology/therapeutic use

22.0

Enzyme Inhibitors/*pharmacology/therapeutic use

26.0

Protein-Tyrosine Kinase/*antagonists & inhibitors

53.0

Breast Neoplasms/drug therapy

26.0

Receptor, erbB-2/immunology/*metabolism

444.0

Signal Transduction/*drug effects

61.0

Antibodies, Monoclonal/*pharmacology

21.0

Apoptosis

80.0

Receptor, erbB-2

4125.0

Adenoviridae/genetics

20.0

Radiation Tolerance

22.0

Tumor Stem Cell Assay

31.0

Antineoplastic Agents, Hormonal/*therapeutic use

56.0

Chemotherapy, Adjuvant

62.0

Cohort Studies

60.0

Drug Resistance

30.0

Postmenopause

52.0

RNA, Neoplasm/metabolism

33.0

Treatment Outcome

90.0

Receptors, Estrogen/*analysis

20.0

Tumor Markers, Biological/genetics/*metabolism

25.0

Neoplasm Invasiveness

121.0

Receptor, erbB-2/analysis

77.0

Epithelial Cells/pathology

22.0

Mitogen-Activated Protein Kinases/*physiology

22.0

Biotinylation

21.0

DNA, Complementary/metabolism

80.0

Immunoprecipitation

20.0

NIH 3T3 Cells

41.0

Receptor, erbB-2/*chemistry

233.0

Ubiquitin/metabolism

31.0

Retrospective Studies

110.0

Risk Factors

90.0

Receptor, Epidermal Growth Factor/biosynthesis/*metabolism

313.0

Signal Transduction/*physiology

80.0

Phosphopyruvate Hydratase/metabolism

35.0

Proliferating Cell Nuclear Antigen/biosynthesis/genetics

228.0

Drug Administration Schedule

30.0

Gene Expression Regulation, Neoplastic/physiology

42.0

Lung Neoplasms/*genetics/pathology

33.0

Neoplasm Metastasis/*genetics/pathology

220.0

Tumor Markers, Biological/*genetics

32.0

Actins/metabolism

40.0

Microfilament Proteins/metabolism

22.0

Phosphoproteins/metabolism

40.0

Tyrphostins/pharmacology

64.0

src-Family Kinases/metabolism

21.0

Fluorescent Antibody Technique

90.0

Heparin/metabolism

21.0

Mice, Inbred C57BL

30.0

Quinazolines/pharmacology

33.0

Receptor, erbB-2/antagonists & inhibitors/*metabolism

2100.0

Tumor Cells, Cultured/drug effects/metabolism

21.0

Transfection/*methods

23.0

Transgenes

20.0

*Signal Transduction

180.0

*Biflavonoids

220.0

*Cacao

2100.0

Catechin/*pharmacology

225.0

DNA Primers

150.0

Flavonoids/pharmacology

30.0

*Proanthocyanidins

220.0

Receptor, erbB-2/genetics

421.0

Cell Division/drug effects/physiology

72.0

Cell Polarity

21.0

Chimeric Proteins/metabolism

21.0

*CDC2-CDC28 Kinases

40.0

Mitogen-Activated Protein Kinases/metabolism/physiology

214.0

Apoptosis/drug effects

50.0

Endothelial Growth Factors/analysis

22.0

Lymphokines/analysis

22.0

Tumor Cells, Cultured/*drug effects

24.0

Vascular Endothelial Growth Factors

50.0

Gene Therapy/methods

22.0

Liposomes

20.0

Gene Expression Regulation, Developmental

20.0

Mammary Glands, Animal/*metabolism

210.0

Mammary Neoplasms, Animal/*metabolism

225.0

Mice, Transgenic

160.0

Neoplasm Recurrence, Local

40.0

Receptor, erbB-3/*biosynthesis

350.0

Statistics

20.0

Drug Delivery Systems

22.0

Enzyme Inhibitors/*therapeutic use

33.0

Receptor, Epidermal Growth Factor/*antagonists & inhibitors/immunology

225.0

Receptor, erbB-2/antagonists & inhibitors

337.0

Cell Transformation, Neoplastic/genetics

20.0

Chromosome Mapping

230.0

*Chromosomes, Human, Pair 17

203.0

DNA Topoisomerases, Type II/*genetics

646.0

*DNA Topoisomerases, Type II, Eukaryotic

210.0

Isoenzymes/*genetics

30.0

Karyotyping

150.0

Metaphase

32.0

Adenocarcinoma/*genetics/pathology

33.0

Calibration

32.0

Crosses, Genetic

40.0

DNA, Neoplasm/genetics

141.0

Disease Models, Animal

80.0

Nucleic Acid Hybridization/*methods

36.0

Breast/*physiology

220.0

Breast Neoplasms/*physiopathology

29.0

Databases, Factual

20.0

Proteins/chemistry

24.0

Alleles

90.0

*Cell Transformation, Neoplastic

51.0

*Genes, p53

71.0

Genotype

50.0

Mammary Neoplasms, Experimental/*genetics/pathology

233.0

Nucleic Acid Hybridization

110.0

Base Sequence

390.0

Computer Systems

23.0

Lymph Nodes/metabolism

23.0

RNA, Messenger/biosynthesis

70.0

Tumor Markers, Biological/*analysis/genetics

25.0

Breast Neoplasms/*drug therapy

23.0

Cell Nucleus/metabolism

20.0

Epidermal Growth Factor/metabolism

82.0

Etoposide/pharmacology

21.0

BRCA2 Protein

30.0

Biological Markers

20.0

Chi-Square Distribution

20.0

Neoplasm Proteins/genetics/*metabolism

21.0

Transcription Factors/genetics/*metabolism

20.0

*DNA Methylation

20.0

Methylation

20.0

RNA, Messenger/genetics/metabolism

30.0

Culture Media, Conditioned

20.0

Solubility

60.0

In Situ Hybridization

90.0

*Nuclear Proteins

50.0

Proto-Oncogene Proteins/genetics/*metabolism

51.0

Epidermal Growth Factor/*metabolism

61.0

Hela Cells

30.0

Sequence Deletion

30.0

Estrogen Receptor Modulators/pharmacology

29.0

Quinazolines/*pharmacology

55.0

Tamoxifen/*pharmacology

34.0

Antineoplastic Agents/therapeutic use

51.0

Receptor, erbB-3/*genetics

266.0

Gene Expression Regulation, Neoplastic/*genetics

21.0

Genes, p53/*genetics

20.0

Mutation/*genetics

20.0

Neoplasm Proteins/biosynthesis/*genetics

33.0

Sequence Homology, Nucleic Acid

40.0

Autocrine Communication

22.0

Carcinoma/genetics

26.0

Cyclin D1/*genetics

23.0

*Genes, myc

62.0

Reference Values

30.0

Thyroid Gland/metabolism

23.0

Antibody Specificity

30.0

Carcinoma, Squamous Cell/*metabolism

21.0

Cell Line, Transformed

60.0

Receptor, erbB-3/metabolism

1655.0

Breast Neoplasms/*metabolism/*pathology

38.0

Follow-Up Studies

90.0

Survival Rate

110.0

Subcellular Fractions

21.0

Tissue Distribution

40.0

Receptors, Estrogen/physiology

310.0

*Peptide Library

35.0

Cell Movement/physiology

20.0

Recombinant Proteins/pharmacology

40.0

Cadherins/*metabolism

34.0

Cell Movement/drug effects

20.0

Point Mutation

40.0

Proteasome Endopeptidase Complex

30.0

Receptors, Cell Surface/metabolism

30.0

Transcription, Genetic/drug effects

30.0

Chromosome Aberrations

112.0

Cyclin D1/genetics

57.0

DNA, Neoplasm/analysis

131.0

Risk Assessment

20.0

Receptor Protein-Tyrosine Kinases/*metabolism

83.0

Mitogen-Activated Protein Kinase 3

71.0

Transforming Growth Factor alpha/metabolism

34.0

*Genes, Tumor Suppressor

50.0

Phosphoric Monoester Hydrolases/*genetics

31.0

Promoter Regions (Genetics)/*genetics

20.0

Tumor Suppressor Proteins/*genetics

43.0

Tumor Markers, Biological/*analysis

90.0

DNA Footprinting

20.0

DNA-Binding Proteins/*metabolism

40.0

*Enhancer Elements (Genetics)

20.0

Forecasting

20.0

Gene Therapy

20.0

Macromolecular Substances

70.0

Repetitive Sequences, Nucleic Acid

30.0

Trans-Activators/*metabolism

20.0

Transcription Factors/*metabolism

30.0

*Adaptor Proteins, Signal Transducing

130.0

Breast Neoplasms/genetics/*metabolism/pathology

49.0

Oligodeoxyribonucleotides, Antisense/pharmacology

24.0

Receptor, erbB-2/*genetics/metabolism

660.0

Estrogen Antagonists/pharmacology

44.0

Estrogens/pharmacology

22.0

Receptor, erbB-2/*drug effects/genetics/metabolism

2100.0

Antibody Affinity

31.0

Epitopes/immunology

20.0

Iodine Radioisotopes

30.0

Acrylamides/*chemical synthesis/chemistry/pharmacology

250.0

Enzyme Inhibitors/*chemical synthesis/chemistry/pharmacology

26.0

Pyrimidines/*chemical synthesis/chemistry/pharmacology

29.0

Quinazolines/*chemical synthesis/chemistry/pharmacology

228.0

Receptor, Epidermal Growth Factor/*antagonists & inhibitors/metabolism

49.0

Transplantation, Heterologous

80.0

Cadherins/metabolism

32.0

Gene Expression Regulation, Neoplastic/drug effects

30.0

Receptor, erbB-2/*antagonists & inhibitors/genetics

266.0

Adenocarcinoma/genetics/pathology

24.0

Carcinoma, Non-Small-Cell Lung/*genetics/pathology

27.0

Genes, erbB-1

316.0

*Ploidies

22.0

Prospective Studies

20.0

Breast Neoplasms/*genetics/metabolism/pathology

59.0

In Situ Hybridization, Fluorescence/*methods

33.0

Reproducibility of Results

70.0

Mice, Inbred ICR

20.0

Mice, SCID

60.0

RNA, Messenger/*genetics

20.0

Central Nervous System Depressants/*pharmacology

212.0

Ethanol/*pharmacology

21.0

Benzoquinones/pharmacology

225.0

Genes, erbB-2/*physiology

675.0

Heat-Shock Proteins 70/metabolism

35.0

Membrane Proteins/metabolism

30.0

Molecular Chaperones/*metabolism

35.0

Phosphotransferases/metabolism

24.0

Protein Structure, Tertiary/physiology

21.0

Drug Resistance, Neoplasm/*physiology

26.0

Genes, Retinoblastoma

22.0

Genes, myc

93.0

*In Situ Hybridization, Fluorescence

42.0

Ki-67 Antigen/analysis

31.0

Receptors, Androgen/genetics

23.0

Animals, Newborn

50.0

Cell Communication

20.0

Coculture Techniques

30.0

Models, Neurological

21.0

Rats, Sprague-Dawley

50.0

Fibroblasts

40.0

Neoplasm Proteins/*metabolism

30.0

Neuregulin-1/*metabolism

642.0

Cell Separation

30.0

*Down-Regulation

20.0

Paclitaxel/therapeutic use

222.0

*Alternative Splicing

20.0

Biological Transport

20.0

Rabbits

20.0

1-Phosphatidylinositol 3-Kinase/antagonists & inhibitors/metabolism

22.0

Blotting, Southern

250.0

Ca(2+)-Calmodulin Dependent Protein Kinase/metabolism

82.0

Serine/metabolism

30.0

Breast/*metabolism

35.0

*Gene Transfer Techniques

20.0

Genes, myc/genetics

33.0

Loss of Heterozygosity

30.0

Multivariate Analysis

100.0

Breast Neoplasms/enzymology/*genetics

27.0

Receptor, Epidermal Growth Factor/*genetics

83.0

Sequence Alignment

60.0

Antibodies, Monoclonal/therapeutic use

42.0

Drug Resistance/genetics

21.0

Ki-67 Antigen/biosynthesis/genetics

240.0

Receptor, Epidermal Growth Factor/biosynthesis/genetics

28.0

Cell Count/drug effects

22.0

*Cell Death

24.0

Culture Media, Serum-Free

20.0

Cell Proliferation/drug effects

33.0

Immunotherapy/methods

22.0

Mice, Inbred NOD

20.0

Oncogene Proteins v-erbB/*metabolism

233.0

RNA, Neoplasm/analysis

20.0

Carcinoma, Squamous Cell/*genetics/pathology

34.0

Centromere/genetics

22.0

Chromosomes, Human/*genetics/ultrastructure

350.0

*Gene Duplication

21.0

Interphase

21.0

*Nucleic Acid Hybridization

47.0

Paraffin Embedding

41.0

Antibodies, Monoclonal

110.0

Fluorescent Antibody Technique, Indirect

40.0

Breast Neoplasms/metabolism/*pathology

33.0

*Cell Cycle Proteins

30.0

Cyclin-Dependent Kinases/metabolism

20.0

Proto-Oncogene Proteins c-myc/metabolism

22.0

Cytoplasm/metabolism

20.0

Protein-Serine-Threonine Kinases/*metabolism

30.0

*ADP Ribose Transferases

67.0

*Bacterial Toxins

42.0

*Virulence Factors

78.0

Breast/metabolism

22.0

Heterozygote

50.0

Proto-Oncogene Proteins/genetics

91.0

*Oncogenes

143.0

Receptor, erbB-2/*antagonists & inhibitors/immunology

3100.0

Breast Neoplasms/*genetics/metabolism

76.0

Receptor, Epidermal Growth Factor/biosynthesis

24.0

Glycoproteins/*metabolism

73.0

Protein p53/*metabolism

30.0

Tumor Markers, Biological/*metabolism

40.0

Cell Movement

30.0

*Proteins

20.0

Receptors, Estrogen/genetics

23.0

Recombinant Proteins/chemistry/metabolism

50.0

Spodoptera

20.0

Chromosomes, Human/*genetics

24.0

Cell Proliferation

31.0

Electrophoresis, Gel, Two-Dimensional

20.0

Luciferases/metabolism

20.0

Luminescent Proteins/metabolism

20.0

Protein Synthesis Inhibitors/pharmacology

20.0

Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

20.0

Antigens, Differentiation/metabolism

21.0

Microscopy, Electron

30.0

*Gene Therapy

41.0

Cell Division/genetics

20.0

Cell Transformation, Neoplastic/*genetics

42.0

DNA, Neoplasm/*genetics

73.0

Bladder/cytology/*metabolism/pathology

266.0

Epidermal Growth Factor/genetics/metabolism/*physiology

240.0

Mice, Inbred Strains

20.0

Mitogens/pharmacology

20.0

Muscle, Smooth/cytology/*metabolism/pathology

2100.0

Urethral Obstruction/*metabolism/pathology

2100.0

Gene Expression/drug effects

30.0

DNA/biosynthesis

20.0

Receptor, erbB-2/chemistry/drug effects/*metabolism

2100.0

DNA, Neoplasm

21.0

Receptor, Epidermal Growth Factor/analysis/biosynthesis

240.0

Colonic Neoplasms/*enzymology/pathology

216.0

Isoenzymes/*metabolism

20.0

Protein-Tyrosine Kinase/*metabolism

20.0

Biopsy, Needle

20.0

Chromosomes, Human, Pair 17

51.0

Neoplasm Proteins/metabolism

30.0

Fibroblast Growth Factors/genetics

25.0

Neoplasm Proteins/genetics

30.0

Breast Neoplasms/*enzymology/metabolism/pathology

225.0

Breast Neoplasms/*genetics/pathology

104.0

*Gene Deletion

40.0

Isoenzymes/metabolism

20.0

Cell Compartmentation/physiology

25.0

DNA, Complementary

30.0

Neuregulins

1424.0

Receptor, erbB-2/analysis/genetics/metabolism

2100.0

1-Phosphatidylinositol 3-Kinase/*physiology

35.0

Ca(2+)-Calmodulin Dependent Protein Kinase/*physiology

28.0

Glycoproteins/*pharmacology

55.0

*Mitogen-Activated Protein Kinases

30.0

Protein-Tyrosine Kinase/metabolism

111.0

Protein Kinase C/*metabolism

20.0

Piperazines/therapeutic use

210.0

Pyrimidines/therapeutic use

29.0

Cytoplasm/enzymology

22.0

Sequence Analysis, DNA

30.0

Genes, Reporter

40.0

Genetic Vectors/*genetics

22.0

Receptor, erbB-2/biosynthesis/*genetics

571.0

Recombinant Fusion Proteins/physiology

20.0

Receptor, Epidermal Growth Factor/antagonists & inhibitors

25.0

Recombinant Proteins/genetics/metabolism

20.0

Tumor Cells, Cultured/physiology

210.0

Receptor, Epidermal Growth Factor/chemistry/*metabolism

38.0

Carrier Proteins/*pharmacology

24.0

*Neuregulin-1

1350.0

Proto-Oncogene Proteins/analysis/*biosynthesis

28.0

Receptor, Epidermal Growth Factor/analysis/*biosynthesis

313.0

Receptor, erbB-2/analysis/*biosynthesis

233.0

Growth Substances/*metabolism

32.0

Protein Binding/genetics

20.0

Proteins/metabolism

80.0

Receptor, Epidermal Growth Factor/*genetics/metabolism

23.0

*Transcription Factors

20.0

Receptor, erbB-2/physiology

337.0

Transforming Growth Factor alpha/*pharmacology

23.0

Receptor, erbB-2/immunology

333.0

Rats, Inbred F344

20.0

Sialoglycoproteins/metabolism

24.0

Exons

40.0

RNA/genetics

21.0

Ca(2+)-Calmodulin Dependent Protein Kinase/*metabolism

20.0

Oligonucleotides, Antisense/pharmacology

41.0

Enzyme Activation/drug effects

80.0

Growth Substances/physiology

21.0

Receptor, Epidermal Growth Factor/metabolism/*physiology

212.0

Receptors, Growth Factor/metabolism

21.0

Carcinoma/*genetics

21.0

Gastrointestinal Neoplasms/*genetics

26.0

Gene Amplification/*genetics

109.0

Genetic Markers

90.0

Hybrid Cells

30.0

Receptor, erbB-2/biosynthesis/genetics/immunology

2100.0

Ki-67 Antigen/metabolism

62.0

Pancreatic Neoplasms/*pathology

25.0

Protein p53/analysis

31.0

Carcinoma

25.0

NF-kappa B/metabolism

20.0

Neurofibromin 1

21.0

Adenocarcinoma/*genetics

32.0

Genes, myc/*genetics

22.0

Proto-Oncogene Proteins/*genetics

141.0

Stomach Neoplasms/*genetics

43.0

*Tumor Cells, Cultured

22.0

*Polymerase Chain Reaction

20.0

Age of Onset

20.0

Intercellular Signaling Peptides and Proteins/metabolism/*pharmacology

250.0

Receptor, Epidermal Growth Factor/drug effects/metabolism

24.0

Receptor, erbB-2/drug effects/metabolism

337.0

Signal Transduction/*drug effects/physiology

23.0

Cell Membrane/chemistry

32.0

Protein Structure, Secondary

40.0

Receptor, erbB-2/metabolism/*physiology

466.0

Chromosome Aberrations/*genetics

21.0

Chromosome Banding

50.0

Chromosome Disorders

51.0

DNA Probes/genetics

21.0

Deoxyribonucleases, Type II Site-Specific/metabolism

21.0

Genes, Structural, Neoplasm

213.0

Epithelial Cells/metabolism

20.0

Breast Neoplasms/epidemiology/*genetics/pathology

225.0

Incidence

20.0

Fluorouracil/administration & dosage

21.0

*Gene Expression Regulation, Neoplastic/drug effects

23.0

Protein p53/*analysis

21.0

*Cell Division

21.0

Combined Modality Therapy

30.0

Carrier Proteins/*metabolism

50.0

Neoplasm Invasiveness/*genetics

25.0

Neoplasm Metastasis/*genetics

35.0

Pseudopodia/metabolism

310.0

Binding Sites, Antibody

30.0

Protein Folding

20.0

*Adaptor Proteins, Vesicular Transport

51.0

Proteins/*metabolism

20.0

*Chromosome Deletion

30.0

Esophageal Neoplasms/*genetics

34.0

Epithelial Cells/*metabolism

43.0

Growth Substances/metabolism

32.0

Receptor, Epidermal Growth Factor/genetics/metabolism

47.0

Receptor, erbB-3/genetics/metabolism

375.0

Reverse Transcriptase Polymerase Chain Reaction/methods

30.0

Carcinoma/*metabolism

22.0

Ovarian Neoplasms/*metabolism/pathology

34.0

Oncogenes

93.0

*Zebrafish Proteins

20.0

Gene Expression/genetics

20.0

Transforming Growth Factor alpha/pharmacology

33.0

Carcinoma, Squamous Cell/metabolism

23.0

Receptor, Epidermal Growth Factor/*biosynthesis

43.0

Immunoglobulin Fragments/*immunology

214.0

Ovarian Neoplasms

25.0

Tumor Markers, Biological/analysis

30.0

Fluorescence Resonance Energy Transfer

24.0

Green Fluorescent Proteins

20.0

Plasmids/metabolism

20.0

*Protein Conformation

20.0

Receptor, erbB-2/chemistry/*metabolism

333.0

Electrophoresis, Polyacrylamide Gel

30.0

*Translocation, Genetic

30.0

Cysteine Endopeptidases/*metabolism

20.0

Rifabutin/*analogs & derivatives/*pharmacology

436.0

Colorectal Neoplasms/pathology

214.0

Mucins/analysis

25.0

Genes, ras

31.0

Proto-Oncogene Proteins c-myc/genetics

23.0

DNA Probes

111.0

Genes, Tumor Suppressor

80.0

Carcinoma, Ductal, Breast/*genetics/pathology

27.0

Chromosome Deletion

40.0

DNA, Neoplasm/isolation & purification

310.0

*Milk Proteins

20.0

Proto-Oncogene Proteins/drug effects/genetics/*metabolism

222.0

Down-Regulation/drug effects

31.0

Antibodies, Monoclonal/immunology/therapeutic use

210.0

Oncogenes/*genetics

56.0

Organ Specificity

20.0

*Transcription, Genetic

30.0

Breast Neoplasms/classification/*genetics/pathology

240.0

Epidermal Growth Factor/metabolism/*pharmacology

34.0

Chromosomes, Human, Pair 11

41.0

Transforming Growth Factor beta/*metabolism

20.0

Estradiol/*pharmacology

20.0

Linkage (Genetics)

30.0

Phosphotyrosine/metabolism

51.0

Aneuploidy

63.0

Gene Deletion

50.0

Ploidies

31.0

Chimeric Proteins

22.0

Luciferases/genetics

20.0

Crystallography, X-Ray

30.0

Receptor Aggregation

22.0

Adenocarcinoma/*enzymology/pathology

222.0

Cell Differentiation/drug effects

20.0

Enzyme Induction/drug effects

20.0

Epithelial Cells

40.0

Protein Processing, Post-Translational

20.0

Receptors, Estrogen/analysis

72.0

Receptors, Progesterone/analysis

52.0

*Cell Cycle

20.0

Mammary Glands, Animal/pathology

233.0

Adenocarcinoma/metabolism/pathology

35.0

Calcium/metabolism

20.0

Carcinoma, Squamous Cell

21.0

Recombinant Proteins

20.0

Receptor, Epidermal Growth Factor/*analysis

41.0

Breast Neoplasms/drug therapy/*genetics/pathology

228.0

Estradiol/*analogs & derivatives/pharmacology

24.0

Tamoxifen/*analogs & derivatives/pharmacology

28.0

Signal Transduction/drug effects/*physiology

20.0

Genes, p53

40.0

DNA, Neoplasm/analysis/genetics

22.0

Immunotherapy

20.0

Receptor, erbB-2/biosynthesis

312.0

Antigens, Neoplasm/metabolism

22.0

Mucins/*metabolism

44.0

Ovarian Neoplasms/*genetics

41.0

BRCA1 Protein

32.0

DNA, Neoplasm/*analysis

21.0

Polymorphism, Single-Stranded Conformational

20.0

Proto-Oncogenes

52.0

Transcription Factors/genetics

30.0

Estradiol/pharmacology

41.0

Oncogenes/genetics

34.0

Immunoglobulin Variable Region

28.0

Fluorouracil/pharmacology

23.0

Chromosomes, Human, Pair 16

32.0

DNA Topoisomerases, Type II, Eukaryotic/*genetics

225.0

Gene Amplification/genetics

35.0

Species Specificity

20.0

Breast Neoplasms/*chemistry/pathology

23.0

Fibroblast Growth Factors/*genetics

24.0

Breast Neoplasms/genetics/*metabolism

46.0

Estrogen Antagonists/*pharmacology

22.0

RNA, Messenger/genetics

90.0

RNA, Neoplasm/genetics

51.0

1-Phosphatidylinositol 3-Kinase

32.0

Immunotoxins/pharmacology

216.0

Phosphotransferases (Alcohol Group Acceptor)/metabolism

22.0

Restriction Mapping

50.0

Breast Neoplasms/etiology/*genetics

26.0

Gastric Mucosa/pathology

25.0

*Point Mutation

20.0

Polymerase Chain Reaction/methods

20.0

Polymorphism, Restriction Fragment Length

90.0

Stomach Neoplasms/*genetics/pathology

24.0

Neoplasm Proteins/*biosynthesis/genetics

21.0

Receptor, erbB-2/*biosynthesis/genetics

225.0

*Breast Neoplasms

315.0

Carrier Proteins/genetics

20.0

Glycoproteins/genetics

22.0

Neoplasms/*drug therapy/metabolism

28.0

*Proto-Oncogenes

192.0

Tamoxifen/pharmacology

22.0

RNA, Neoplasm/*analysis

24.0

Phosphotyrosine

31.0

Proto-Oncogene Proteins/*physiology

20.0

Tyrosine/analogs & derivatives/metabolism

32.0

Genes, p53/genetics

31.0

Neoplasm Metastasis/genetics

24.0

*Chromosomes, Human, Pair 1

20.0

Cricetulus

30.0

Neuroblastoma/*genetics

22.0

Immunologic Techniques

20.0

Case-Control Studies

40.0

Gene Expression Regulation/*physiology

20.0

Cyclin D1/*metabolism

23.0

Gene Frequency

20.0

Neoplasm Proteins/*genetics

20.0

Tamoxifen/therapeutic use

23.0

Proto-Oncogenes/*genetics

45.0

Proto-Oncogene Proteins/analysis

31.0

DNA Primers/genetics

20.0

Antineoplastic Agents/pharmacology/therapeutic use

26.0

Neoplasms/drug therapy/metabolism

211.0

Morphogenesis

20.0

Conserved Sequence

20.0

Receptor, Epidermal Growth Factor/*analysis/biosynthesis

222.0

Breast Neoplasms/*chemistry/genetics

215.0

Lactams, Macrocyclic

2100.0

MAP Kinase Signaling System/drug effects

22.0

DNA, Neoplasm/genetics/isolation & purification

32.0

Receptors, Estrogen/biosynthesis

36.0

Carcinoma, Squamous Cell/*genetics

42.0

Variation (Genetics)

20.0

Ovarian Neoplasms/*genetics/pathology

22.0

Genetic Markers/genetics

20.0

*Bile Ducts, Intrahepatic

26.0

*Multigene Family

20.0

Carcinoma/*genetics/pathology

23.0

Neuregulin-1/*pharmacology

423.0

Epithelium/pathology

21.0

Cyclin D1/metabolism

21.0

Proto-Oncogene Proteins c-bcl-2/metabolism

20.0

Retinoblastoma Protein/metabolism

20.0

Germany

20.0

Receptors, Cell Surface/*metabolism

20.0

Antibodies, Monoclonal/administration & dosage

26.0

Melanoma/pathology

26.0

*Polymorphism, Restriction Fragment Length

20.0

Insulin-Like Growth Factor I/*metabolism

21.0

Epidermal Growth Factor/genetics

22.0

Protein-Tyrosine Kinase/*genetics

20.0

Receptor, erbB-2/*antagonists & inhibitors/metabolism

225.0

Cyclin D1/biosynthesis

24.0

Signal Transduction/genetics

20.0

Protein-Tyrosine Kinase/genetics

21.0

Lung Neoplasms/genetics

23.0

Actins/genetics

21.0

Platelet-Derived Growth Factor/genetics

26.0

Pancreatic Neoplasms/genetics

25.0

RNA, Messenger/*metabolism

20.0

Astrocytoma/*genetics

24.0

Double-Blind Method

20.0

Nitriles/*therapeutic use

233.0

Triazoles/*therapeutic use

228.0

Receptor, erbB-2/deficiency/genetics/*physiology

2100.0

Algorithms

20.0

Expressed Sequence Tags

20.0

Gene Expression Profiling/*methods

22.0

Oligonucleotide Array Sequence Analysis/*methods

21.0

*Signal Transduction/drug effects

22.0

DNA/metabolism

20.0

Molecular Weight

20.0

Mitogen-Activated Protein Kinase Kinases/metabolism

21.0

Receptor, erbB-2/antagonists & inhibitors/*physiology

250.0

Esophageal Neoplasms/*genetics/pathology

26.0

Quality Control

21.0

*Genes, Structural

30.0

Ki-67 Antigen/biosynthesis

22.0

Receptors, Progesterone/biosynthesis

26.0

Rifabutin/*analogs & derivatives/pharmacology

250.0

Introns

20.0

*Promoter Regions (Genetics)

20.0

Cell Death

20.0

Hydrogen Bonding

21.0

Cyclins/*metabolism

20.0

Cytoskeletal Proteins/*metabolism

21.0

Cytoskeletal Proteins/metabolism

20.0

DNA-Binding Proteins/metabolism

20.0

Trans-Activators/metabolism

30.0

DNA-Binding Proteins/genetics

20.0

Protein p53/metabolism

20.0

Drug Combinations

20.0

Bladder Neoplasms/*genetics

22.0

MAP Kinase Kinase 1

21.0

Neuregulin-1/genetics/*metabolism

2100.0