MeSH term
Frequency | Condition_Probility | Aged | 31 | 0.0 |
Aged, 80 and over | 15 | 0.0 |
Female | 59 | 0.0 |
Humans | 234 | 0.0 |
English Abstract | 6 | 0.0 |
United States | 3 | 0.0 |
Animals | 106 | 0.0 |
Fibroblasts/pathology | 2 | 2.0 |
Fibrosis | 13 | 9.0 |
Immediate-Early Proteins/*genetics | 22 | 34.0 |
Intercellular Signaling Peptides and Proteins/*genetics | 10 | 16.0 |
Male | 54 | 0.0 |
Middle Aged | 36 | 0.0 |
Neoplasm Staging | 2 | 0.0 |
Prognosis | 3 | 0.0 |
RNA, Messenger/genetics | 9 | 0.0 |
Research Support, Non-U.S. Gov't | 170 | 0.0 |
Survival Analysis | 3 | 0.0 |
Transforming Growth Factor beta/physiology | 8 | 8.0 |
Binding Sites | 8 | 0.0 |
Cattle | 8 | 0.0 |
DNA, Complementary/metabolism | 2 | 0.0 |
Endothelium, Vascular/cytology | 2 | 0.0 |
Immediate-Early Proteins/*metabolism | 15 | 25.0 |
Immunoblotting | 2 | 0.0 |
Intercellular Signaling Peptides and Proteins/*metabolism | 10 | 10.0 |
Interstitial Collagenase/metabolism | 2 | 8.0 |
Matrix Metalloproteinases/*metabolism | 3 | 7.0 |
*Neovascularization, Pathologic | 2 | 0.0 |
*Neovascularization, Physiologic | 2 | 1.0 |
Protein Binding | 13 | 0.0 |
Recombinant Proteins/metabolism | 8 | 0.0 |
Stromelysin 1/metabolism | 2 | 13.0 |
Time Factors | 11 | 0.0 |
Vascular Endothelial Growth Factor A | 8 | 0.0 |
Vascular Endothelial Growth Factors | 8 | 0.0 |
Growth Substances/*metabolism | 11 | 7.0 |
Immunoenzyme Techniques | 9 | 0.0 |
*Intercellular Signaling Peptides and Proteins | 103 | 19.0 |
Models, Biological | 4 | 0.0 |
Research Support, U.S. Gov't, P.H.S. | 74 | 0.0 |
Transforming Growth Factor beta/metabolism | 13 | 6.0 |
Up-Regulation | 12 | 0.0 |
Adult | 33 | 0.0 |
Disease Progression | 6 | 0.0 |
Immediate-Early Proteins/analysis | 2 | 50.0 |
Predictive Value of Tests | 2 | 0.0 |
RNA, Messenger/*analysis | 2 | 0.0 |
Antibodies, Monoclonal/pharmacology | 2 | 0.0 |
Cell Division/drug effects | 7 | 0.0 |
Cell Movement/drug effects/physiology | 2 | 3.0 |
Collagen Type I/genetics/metabolism | 2 | 22.0 |
DNA Primers/chemistry | 2 | 0.0 |
Dose-Response Relationship, Drug | 11 | 0.0 |
Platelet-Derived Growth Factor/pharmacology | 3 | 1.0 |
RNA, Messenger/metabolism | 25 | 0.0 |
Rats | 36 | 0.0 |
Rats, Sprague-Dawley | 11 | 0.0 |
Recombinant Proteins | 2 | 0.0 |
Reverse Transcriptase Polymerase Chain Reaction | 29 | 0.0 |
Cell Adhesion/physiology | 3 | 1.0 |
Disease Models, Animal | 7 | 0.0 |
Immunohistochemistry | 21 | 0.0 |
Mice | 44 | 0.0 |
Mice, Knockout | 3 | 0.0 |
Protein Structure, Tertiary | 4 | 0.0 |
Receptor, PAR-1 | 3 | 14.0 |
Culture Media, Conditioned | 2 | 0.0 |
Enzyme-Linked Immunosorbent Assay | 10 | 0.0 |
Fluorescent Antibody Technique | 2 | 0.0 |
Growth Substances/genetics/*physiology | 5 | 29.0 |
Immediate-Early Proteins/genetics/*physiology | 2 | 18.0 |
RNA, Messenger/genetics/metabolism | 11 | 0.0 |
Tumor Cells, Cultured | 20 | 0.0 |
Amino Acid Sequence | 12 | 0.0 |
Extracellular Matrix/*metabolism | 4 | 4.0 |
Molecular Sequence Data | 25 | 0.0 |
Sequence Homology, Amino Acid | 9 | 0.0 |
Signal Transduction | 15 | 0.0 |
Transforming Growth Factor beta/genetics/*physiology | 3 | 21.0 |
Cell Differentiation | 4 | 0.0 |
Oligonucleotide Array Sequence Analysis | 13 | 1.0 |
Blotting, Western | 19 | 0.0 |
Cells, Cultured | 54 | 0.0 |
Fibroblasts/metabolism | 13 | 1.0 |
RNA, Messenger/biosynthesis/genetics | 5 | 0.0 |
Recombinant Proteins/pharmacology | 12 | 0.0 |
Research Support, U.S. Gov't, Non-P.H.S. | 12 | 0.0 |
Flow Cytometry | 3 | 0.0 |
*Gene Expression Regulation, Neoplastic | 6 | 0.0 |
*Immediate-Early Proteins | 38 | 15.0 |
Growth Substances/*physiology | 4 | 2.0 |
Immediate-Early Proteins/*physiology | 9 | 34.0 |
Scleroderma, Systemic/*etiology | 2 | 66.0 |
Immediate-Early Proteins/genetics/*metabolism | 12 | 21.0 |
Intercellular Signaling Peptides and Proteins/genetics/*metabolism | 7 | 21.0 |
Interleukin-1/pharmacology | 2 | 0.0 |
Mitogen-Activated Protein Kinases/metabolism | 5 | 0.0 |
Signal Transduction/drug effects | 3 | 0.0 |
Trans-Activators/metabolism | 4 | 0.0 |
Transforming Growth Factor beta/*pharmacology | 13 | 3.0 |
Cell Line | 22 | 0.0 |
*Gene Expression Profiling | 5 | 1.0 |
Gene Expression Regulation/drug effects | 11 | 1.0 |
Kinetics | 9 | 0.0 |
RNA, Messenger/biosynthesis | 7 | 0.0 |
Stress, Mechanical | 5 | 1.0 |
Transforming Growth Factor beta/pharmacology | 12 | 3.0 |
Child | 7 | 0.0 |
Gene Expression | 10 | 0.0 |
Infant, Newborn | 6 | 0.0 |
Cyclic AMP-Dependent Protein Kinases/metabolism | 3 | 1.0 |
*Gene Expression Regulation | 9 | 0.0 |
Granulosa Cells/*metabolism | 2 | 5.0 |
Growth Substances/biosynthesis/*genetics | 3 | 21.0 |
Immediate-Early Proteins/biosynthesis/*genetics | 5 | 71.0 |
Protein Kinase C/metabolism | 4 | 0.0 |
Collagen/*biosynthesis | 5 | 12.0 |
Blotting, Northern | 19 | 0.0 |
Comparative Study | 29 | 0.0 |
In Situ Hybridization | 19 | 0.0 |
RNA, Messenger/analysis | 19 | 0.0 |
Rats, Wistar | 5 | 0.0 |
Growth Substances/*biosynthesis/genetics | 6 | 23.0 |
Immediate-Early Proteins/*biosynthesis/genetics | 8 | 61.0 |
Mice, Inbred C57BL | 2 | 0.0 |
Two-Hybrid System Techniques | 2 | 0.0 |
Biopsy | 5 | 0.0 |
Cross-Sectional Studies | 2 | 0.0 |
Diabetic Nephropathies/*metabolism/pathology | 2 | 50.0 |
Growth Substances/*genetics | 18 | 17.0 |
RNA, Messenger/*metabolism | 4 | 0.0 |
Aorta | 2 | 1.0 |
Chickens | 5 | 0.0 |
Endothelial Growth Factors/pharmacology | 2 | 1.0 |
Fibroblast Growth Factor 2/pharmacology | 3 | 1.0 |
Growth Substances/analysis/*genetics | 5 | 55.0 |
Immediate-Early Proteins/analysis/*genetics | 4 | 80.0 |
Lymphokines/pharmacology | 3 | 1.0 |
Mice, Nude | 5 | 0.0 |
Transplantation, Heterologous | 2 | 0.0 |
Cell Division | 8 | 0.0 |
Fibroblasts/drug effects/*metabolism/pathology | 2 | 100.0 |
Growth Substances/pharmacology | 2 | 1.0 |
Microscopy, Confocal | 2 | 0.0 |
Phenotype | 5 | 0.0 |
Phosphoproteins/metabolism | 2 | 0.0 |
Reactive Oxygen Species/metabolism | 2 | 0.0 |
Scleroderma, Localized/*metabolism | 2 | 100.0 |
Scleroderma, Systemic/*metabolism/pathology | 3 | 50.0 |
DNA-Binding Proteins/physiology | 4 | 1.0 |
Multigene Family | 3 | 0.0 |
Receptors, Transforming Growth Factor beta/metabolism | 3 | 6.0 |
Trans-Activators/physiology | 4 | 2.0 |
Protein Synthesis Inhibitors/pharmacology | 5 | 1.0 |
Transcription Factors/genetics | 3 | 0.0 |
Cholera Toxin/pharmacology | 2 | 2.0 |
DNA-Binding Proteins/metabolism | 3 | 0.0 |
Enzyme Inhibitors/pharmacology | 6 | 0.0 |
Fibroblasts/cytology/drug effects/*metabolism | 2 | 13.0 |
Protein Isoprenylation/drug effects | 2 | 11.0 |
Protein Kinase C/antagonists & inhibitors/metabolism | 2 | 2.0 |
Antibodies/pharmacology | 4 | 1.0 |
Diabetic Nephropathies/*metabolism | 2 | 22.0 |
Cell Culture Techniques | 3 | 0.0 |
Fibroblasts | 7 | 1.0 |
Transforming Growth Factor beta/immunology | 2 | 22.0 |
Bronchoalveolar Lavage Fluid/cytology | 2 | 1.0 |
Collagen/*metabolism | 2 | 1.0 |
Prothrombin Time | 2 | 1.0 |
*Drosophila Proteins | 2 | 0.0 |
Phylogeny | 2 | 0.0 |
Sequence Alignment | 6 | 0.0 |
Software | 2 | 0.0 |
Fluorescent Antibody Technique, Indirect | 2 | 0.0 |
Glomerular Mesangium/cytology/*metabolism | 2 | 8.0 |
Phosphorylation | 6 | 0.0 |
Precipitin Tests | 7 | 0.0 |
Tetradecanoylphorbol Acetate/pharmacology | 2 | 0.0 |
Transfection | 17 | 0.0 |
Cloning, Molecular | 9 | 0.0 |
DNA, Complementary | 4 | 0.0 |
Fibronectins/metabolism | 4 | 2.0 |
Intercellular Signaling Peptides and Proteins/*physiology | 6 | 23.0 |
Kidney/metabolism | 2 | 0.0 |
Oligonucleotides, Antisense/pharmacology | 6 | 2.0 |
Recombinant Fusion Proteins/metabolism | 3 | 0.0 |
Gene Expression Regulation | 9 | 0.0 |
Transcription, Genetic | 9 | 0.0 |
Biological Markers/blood | 2 | 0.0 |
Reference Values | 5 | 0.0 |
Skin/*pathology | 3 | 3.0 |
Growth Substances/genetics/*metabolism | 9 | 21.0 |
Antigens, CD31/analysis | 2 | 2.0 |
Immediate-Early Proteins/*analysis | 5 | 83.0 |
Mitogens/*analysis | 3 | 100.0 |
Transforming Growth Factor beta/analysis | 2 | 4.0 |
RNA, Messenger/drug effects/genetics/metabolism | 2 | 2.0 |
Simvastatin/pharmacology | 2 | 11.0 |
rho GTP-Binding Proteins/*physiology | 2 | 5.0 |
Down-Regulation | 6 | 0.0 |
Extracellular Matrix/genetics/*metabolism | 2 | 66.0 |
Collagen/biosynthesis | 3 | 6.0 |
Lens, Crystalline/cytology/*metabolism | 2 | 22.0 |
Cell Proliferation/drug effects | 2 | 2.0 |
Signal Transduction/drug effects/physiology | 2 | 0.0 |
Base Sequence | 21 | 0.0 |
Intercellular Signaling Peptides and Proteins/*biosynthesis/genetics | 3 | 9.0 |
Mice, Transgenic | 2 | 0.0 |
Promoter Regions (Genetics)/genetics | 3 | 0.0 |
Oligonucleotides, Antisense/*pharmacology | 2 | 2.0 |
Actins/genetics | 2 | 1.0 |
Fibronectins/genetics | 3 | 10.0 |
Gene Expression Regulation/drug effects/*physiology | 3 | 3.0 |
Transforming Growth Factor beta/*genetics | 3 | 3.0 |
Genotype | 3 | 0.0 |
*Promoter Regions (Genetics) | 2 | 0.0 |
Astrocytes/*metabolism | 2 | 3.0 |
Endothelium, Vascular/*metabolism/pathology | 2 | 5.0 |
Fibroblasts/*metabolism/pathology | 2 | 8.0 |
Tissue Distribution | 5 | 0.0 |
Cell Count | 2 | 0.0 |
Cell Culture Techniques/methods | 2 | 0.0 |
Cell Differentiation/*genetics | 2 | 2.0 |
Gene Library | 2 | 0.0 |
Proteoglycans/biosynthesis | 2 | 18.0 |
Intercellular Signaling Peptides and Proteins/*analysis | 4 | 14.0 |
Mutagenesis, Site-Directed | 2 | 0.0 |
Neovascularization, Physiologic/*physiology | 3 | 2.0 |
Recombinant Proteins/chemistry/metabolism | 2 | 0.0 |
Umbilical Veins | 4 | 0.0 |
Gene Expression Regulation, Neoplastic | 5 | 0.0 |
Growth Substances/*genetics/metabolism | 3 | 13.0 |
Neoplasm Proteins/*genetics/metabolism | 3 | 2.0 |
Cell Survival | 3 | 0.0 |
Collagen/genetics | 4 | 4.0 |
DNA Fragmentation | 3 | 0.0 |
Gene Expression Regulation/*physiology | 3 | 0.0 |
Species Specificity | 2 | 0.0 |
Fibroblasts/drug effects/physiology | 2 | 10.0 |
Transforming Growth Factor beta/antagonists & inhibitors/*pharmacology | 3 | 23.0 |
Adolescent | 11 | 0.0 |
Child, Preschool | 6 | 0.0 |
Infant | 4 | 0.0 |
Up-Regulation/drug effects | 4 | 1.0 |
Transforming Growth Factor beta/genetics/metabolism | 4 | 11.0 |
Cell Differentiation/physiology | 4 | 0.0 |
Protein-Lysine 6-Oxidase/*genetics | 2 | 22.0 |
3T3 Cells | 7 | 0.0 |
Immediate-Early Proteins/metabolism | 4 | 13.0 |
Transforming Growth Factor beta/*metabolism | 4 | 1.0 |
Actins/metabolism | 5 | 0.0 |
Collagen/metabolism | 5 | 1.0 |
Tenascin/metabolism | 2 | 20.0 |
Cell Division/physiology | 2 | 0.0 |
Wound Healing | 2 | 1.0 |
Cell Adhesion | 7 | 0.0 |
Cell Membrane/metabolism | 2 | 0.0 |
Enzyme Activation | 3 | 0.0 |
Fibroblasts/*metabolism | 7 | 4.0 |
Integrins/metabolism | 2 | 1.0 |
Microscopy, Fluorescence | 2 | 0.0 |
Mitogen-Activated Protein Kinase 1/metabolism | 2 | 0.0 |
Mitogen-Activated Protein Kinase 3 | 3 | 0.0 |
RNA/metabolism | 2 | 0.0 |
Wound Healing/physiology | 5 | 8.0 |
Immediate-Early Proteins/*analysis/genetics | 2 | 66.0 |
Pregnancy | 3 | 0.0 |
Epithelium/physiology | 2 | 2.0 |
Genes, Reporter | 2 | 0.0 |
Mitogens/genetics | 5 | 50.0 |
*Transcription, Genetic | 2 | 0.0 |
Biological Markers | 4 | 0.0 |
Vimentin/metabolism | 2 | 1.0 |
Fibroblasts/metabolism/pathology | 2 | 4.0 |
Liver/cytology/metabolism | 2 | 4.0 |
Cycloheximide/pharmacology | 4 | 0.0 |
Coculture Techniques | 3 | 0.0 |
In Vitro | 4 | 0.0 |
Up-Regulation/genetics | 2 | 2.0 |
Biological Markers/analysis | 2 | 0.0 |
Immunohistochemistry/methods | 2 | 0.0 |
Gene Expression Profiling | 3 | 0.0 |
RNA, Messenger/analysis/biosynthesis | 2 | 0.0 |
Horses | 2 | 1.0 |
Immediate-Early Proteins/pharmacology | 2 | 50.0 |
Insulin-Like Growth Factor I/pharmacology | 2 | 1.0 |
Peptide Fragments/pharmacology | 2 | 0.0 |
Swine | 5 | 0.0 |
Catalysis | 2 | 0.0 |
Cell Line, Tumor | 5 | 0.0 |
NIH 3T3 Cells | 2 | 0.0 |
Scleroderma, Systemic/*metabolism | 2 | 15.0 |
*Gene Expression | 4 | 0.0 |
Fibroblasts/cytology/drug effects/metabolism | 2 | 3.0 |
Luciferases/genetics | 2 | 0.0 |
Promoter Regions (Genetics) | 4 | 0.0 |
*Signal Transduction | 2 | 0.0 |
Aorta/cytology/drug effects | 2 | 40.0 |
Apoptosis/*drug effects | 2 | 0.0 |
Cell Survival/drug effects | 2 | 0.0 |
DNA Fragmentation/drug effects | 2 | 2.0 |
Growth Substances/*pharmacology | 4 | 1.0 |
Immediate-Early Proteins/*pharmacology | 4 | 66.0 |
Growth Substances/chemistry/*genetics | 2 | 33.0 |
Glomerular Mesangium/*metabolism/pathology | 2 | 50.0 |
Glucose/metabolism | 2 | 0.0 |
Rats, Inbred F344 | 3 | 0.0 |
Transforming Growth Factor beta/*physiology | 5 | 3.0 |
Adenoviridae/genetics | 2 | 0.0 |
Cell Differentiation/drug effects | 2 | 0.0 |
Rabbits | 5 | 0.0 |
Caspases/metabolism | 2 | 0.0 |
*Apoptosis | 2 | 0.0 |
Fibrosis/etiology | 2 | 28.0 |
Gene Expression/drug effects | 2 | 0.0 |
Cell Line, Transformed | 4 | 0.0 |
Fibrosis/physiopathology | 3 | 60.0 |
Mice, Inbred BALB C | 4 | 0.0 |
Mitogens/*pharmacology | 3 | 2.0 |
Homeostasis | 2 | 0.0 |
*Platelet Activation | 2 | 1.0 |
Growth Substances/genetics | 3 | 4.0 |
Transforming Growth Factor beta/pharmacology/*physiology | 2 | 8.0 |
Immediate-Early Proteins/genetics | 3 | 6.0 |
Intercellular Signaling Peptides and Proteins/genetics | 2 | 7.0 |
RNA, Messenger/drug effects/metabolism | 2 | 1.0 |
Osmolar Concentration | 2 | 0.0 |
Receptors, Transforming Growth Factor beta/analysis | 2 | 18.0 |
Gene Expression Regulation/*drug effects | 5 | 0.0 |
Nucleic Acid Hybridization | 2 | 0.0 |
Sequence Homology, Nucleic Acid | 3 | 0.0 |
Immediate-Early Proteins/genetics/metabolism | 3 | 17.0 |
Dogs | 2 | 0.0 |
Recombinant Fusion Proteins/biosynthesis | 2 | 0.0 |
Intercellular Signaling Peptides and Proteins/genetics/metabolism | 2 | 9.0 |
DNA Primers | 4 | 0.0 |
Fibroblasts/drug effects | 3 | 3.0 |
Platelet-Derived Growth Factor/metabolism | 2 | 3.0 |
Receptors, Platelet-Derived Growth Factor/metabolism | 2 | 4.0 |
Molecular Weight | 2 | 0.0 |
Chondrocytes/*metabolism | 2 | 6.0 |
Mitogens/*genetics | 2 | 28.0 |
Sclerosis | 2 | 3.0 |
Extracellular Matrix Proteins/biosynthesis/genetics | 2 | 28.0 |
Immediate-Early Proteins/physiology | 2 | 22.0 |
Intercellular Signaling Peptides and Proteins/physiology | 2 | 11.0 |
Actins/biosynthesis/genetics | 2 | 13.0 |
Cell Movement/physiology | 2 | 0.0 |
Epithelial Cells/metabolism | 2 | 0.0 |
Signal Transduction/*physiology | 5 | 0.0 |
Polymerase Chain Reaction | 2 | 0.0 |
Immediate-Early Proteins/*genetics/*metabolism | 2 | 33.0 |
Intercellular Signaling Peptides and Proteins/*genetics/*metabolism | 2 | 40.0 |
Skin/metabolism/*pathology | 2 | 28.0 |
Transforming Growth Factor beta/genetics | 2 | 2.0 |
Extracellular Matrix/metabolism | 5 | 2.0 |
Growth Substances/metabolism | 2 | 1.0 |
Intercellular Signaling Peptides and Proteins/biosynthesis/*genetics | 3 | 42.0 |
Gene Deletion | 2 | 0.0 |
Crystallization | 2 | 0.0 |
Risk Factors | 2 | 0.0 |
RNA, Messenger/*biosynthesis | 2 | 0.0 |
Scleroderma, Systemic/*pathology | 2 | 28.0 |
Immediate-Early Proteins/pharmacology/*physiology | 3 | 75.0 |
Intercellular Signaling Peptides and Proteins/pharmacology/*physiology | 3 | 30.0 |
Kidney | 2 | 0.0 |
Neoplasm Invasiveness | 2 | 0.0 |
Oligonucleotides, Antisense | 2 | 2.0 |
Cell Movement | 3 | 0.0 |
Endothelium, Vascular/cytology/*physiology | 3 | 4.0 |
*Gene Expression Regulation/drug effects | 2 | 1.0 |
*Wound Healing | 2 | 3.0 |
Gene Expression Regulation/physiology | 2 | 0.0 |
Gene Expression Regulation, Neoplastic/genetics | 2 | 1.0 |
Neovascularization, Pathologic/*physiopathology | 2 | 2.0 |
Culture Media | 2 | 0.0 |
Hypertrophy | 3 | 2.0 |
Intercellular Signaling Peptides and Proteins/metabolism | 5 | 6.0 |
Liver/metabolism/*pathology | 2 | 10.0 |
Electrophoresis, Polyacrylamide Gel | 2 | 0.0 |
Mitogens/metabolism | 3 | 12.0 |
Antibodies, Monoclonal | 2 | 0.0 |
Insulin-Like Growth Factor Binding Proteins/metabolism | 2 | 18.0 |
Angiotensin II/*pharmacology | 2 | 1.0 |
Fibrosis/metabolism | 2 | 16.0 |
Lung/pathology | 2 | 2.0 |
Cell Adhesion/drug effects | 3 | 0.0 |
Pyridines/pharmacology | 2 | 0.0 |
Enzyme Induction | 2 | 0.0 |
Blood Pressure | 2 | 0.0 |
Signal Transduction/physiology | 3 | 0.0 |
Chondrocytes/*cytology | 2 | 12.0 |
Up-Regulation/physiology | 2 | 1.0 |
Glial Fibrillary Acidic Protein/metabolism | 2 | 0.0 |
Glutathione Transferase/metabolism | 2 | 0.0 |
Phosphorylation/drug effects | 2 | 0.0 |
Solubility | 2 | 0.0 |
Intercellular Signaling Peptides and Proteins/*pharmacology | 2 | 6.0 |
Proline/metabolism | 2 | 3.0 |
Stimulation, Chemical | 2 | 0.0 |
