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Taipei Medical University

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Gene Symbol
Gene NameAliasesPrevious_Symbol

CDKN2A

cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)CDK4I, p16, INK4a, MTS1, CMM2, ARF, p19, p14, INK4


Gene CDKN2A gene interaction
View Neighborhood Gene

Result number fewer <<<< << < ALL > >> >>> more

MeSH term
FrequencyCondition_Probility

Animals

380.0

Humans

3110.0

Comparative Study

280.0

*DNA Methylation

274.0

DNA, Neoplasm/*genetics

31.0

Disease Progression

200.0

Follow-Up Studies

20.0

Gene Expression Regulation, Neoplastic

130.0

Middle Aged

1110.0

Precancerous Conditions/*genetics

27.0

*Promoter Regions (Genetics)

60.0

Prospective Studies

60.0

Protein p16/*genetics

5457.0

Research Support, Non-U.S. Gov't

2280.0

Risk Factors

160.0

Cyclin-Dependent Kinases/*genetics

1421.0

Dysplastic Nevus Syndrome/*genetics/pathology

2100.0

*Genes, p16

4748.0

Melanoma/*genetics/pathology

725.0

*Mutation

270.0

*Proto-Oncogene Proteins

291.0

Research Support, U.S. Gov't, P.H.S.

630.0

Skin Neoplasms/*genetics/pathology

610.0

Cell Division

100.0

In Situ Hybridization

30.0

Loss of Heterozygosity

414.0

Mutation

490.0

Polymerase Chain Reaction

500.0

Polymorphism, Genetic/*genetics

30.0

Promoter Regions (Genetics)/*genetics

40.0

Protein p16/metabolism

610.0

Survival Analysis

180.0

Australia

52.0

Genes, p16

2828.0

*Genetic Predisposition to Disease

121.0

Melanoma/epidemiology/*genetics

960.0

United States

20.0

Variation (Genetics)

50.0

Alleles

210.0

Child

300.0

*Chromosome Deletion

121.0

In Situ Hybridization, Fluorescence

140.0

Prognosis

260.0

Adult

1040.0

Cells, Cultured

60.0

Gene Deletion

271.0

Male

1410.0

Protein p16/genetics/*metabolism

422.0

Protein p53/metabolism

30.0

Ultraviolet Rays

20.0

p14ARF Protein/genetics/*metabolism

222.0

Aged

860.0

Immunohistochemistry

190.0

Risk

40.0

Sequence Analysis, DNA

100.0

Base Sequence

300.0

DNA, Neoplasm

43.0

Female

1420.0

Genetic Predisposition to Disease

261.0

*Germ-Line Mutation

163.0

Melanoma/*genetics

6241.0

Molecular Sequence Data

360.0

Mutation, Missense

40.0

Pedigree

410.0

Protein p16/genetics

1720.0

Tumor Suppressor Proteins/*genetics

21.0

p14ARF Protein/*genetics

728.0

Aged, 80 and over

300.0

Cell Cycle

80.0

Codon

40.0

DNA Mutational Analysis

400.0

Exons

140.0

*Genes, p53

51.0

Homozygote

120.0

Models, Genetic

50.0

Polymorphism, Genetic

130.0

Promoter Regions (Genetics)

170.0

Protein p53/biosynthesis

21.0

Sulfites/pharmacology

26.0

Chromosomes, Human, Pair 9/*genetics

1816.0

*Gene Deletion

222.0

Gene Dosage

51.0

Bladder Neoplasms/*genetics

33.0

Carcinoma, Transitional Cell/genetics

228.0

Chromosome Aberrations

61.0

Chromosome Deletion

101.0

Chromosome Painting

36.0

Gene Expression

40.0

*Genes, Tumor Suppressor

141.0

Genetic Markers/genetics

30.0

Loss of Heterozygosity/genetics

107.0

Tumor Cells, Cultured

470.0

Translocation, Genetic

20.0

Adolescent

410.0

Australia/epidemiology

23.0

Case-Control Studies

80.0

Melanoma/*epidemiology/etiology/genetics

2100.0

Sunlight/adverse effects

210.0

Antineoplastic Combined Chemotherapy Protocols/therapeutic use

20.0

Treatment Outcome

40.0

Vincristine/administration & dosage

21.0

*Cell Cycle Proteins

181.0

Enzyme Inhibitors

33.0

Genotype

160.0

Recombinant Fusion Proteins/physiology

20.0

Transfection

90.0

Family Health

131.0

Nevus/genetics

2100.0

Skin Neoplasms/*genetics

3226.0

Age of Onset

40.0

Germ-Line Mutation

123.0

Pancreatic Neoplasms/*genetics/pathology

25.0

Phenotype

180.0

*Genetic Markers

30.0

Signal Transduction

30.0

Amino Acid Sequence

140.0

Cell Line, Tumor

50.0

Chromosomes, Human, Pair 9/genetics

1613.0

DNA, Neoplasm/genetics

151.0

Gene Amplification

70.0

*Genes, abl

27.0

Age Factors

80.0

Child, Preschool

150.0

CpG Islands/genetics

75.0

Amino Acid Substitution

30.0

DNA, Neoplasm/chemistry/genetics

75.0

Gene Frequency

20.0

Italy

50.0

Polymorphism, Single-Stranded Conformational

361.0

Promoter Regions (Genetics)/genetics

30.0

Astrocytoma/*genetics/pathology

28.0

Brain Neoplasms/*genetics/pathology

57.0

Chromosomes, Human, Pair 1/*genetics

31.0

Cyclin-Dependent Kinases/genetics

1525.0

DNA, Neoplasm/analysis

141.0

Molecular Biology

20.0

Neoplasm Proteins/*genetics

20.0

Neoplasm Staging

100.0

Oligodendroglioma/*genetics/pathology

216.0

Protein p53/genetics

74.0

Receptor, Epidermal Growth Factor/genetics

65.0

Tumor Markers, Biological/genetics

22.0

Cell Cycle Proteins/*genetics/metabolism

23.0

Chi-Square Distribution

20.0

Protein p16/*genetics/metabolism

945.0

*Tumor Suppressor Proteins

312.0

Ependymoma/*genetics/pathology

240.0

Methylation

40.0

Reverse Transcriptase Polymerase Chain Reaction

210.0

Blotting, Southern

90.0

Blotting, Western

70.0

Gene Expression Regulation, Neoplastic/*drug effects

20.0

Gene Silencing

82.0

RNA, Messenger/genetics/metabolism

40.0

Bladder Neoplasms/*genetics/pathology

25.0

Chromosome Mapping

240.0

*Chromosomes, Human, Pair 9

176.0

DNA Methylation

233.0

Genes, Tumor Suppressor

131.0

Microsatellite Repeats

231.0

Neoplasm Recurrence, Local/genetics

29.0

Sequence Deletion

70.0

Tumor Suppressor Proteins/genetics

68.0

Alternative Splicing/genetics

21.0

Haplotypes

60.0

Point Mutation

120.0

Polymerase Chain Reaction/methods

70.0

Germ-Line Mutation/*genetics

85.0

Head and Neck Neoplasms/*genetics/pathology

26.0

Protein p16/analysis/*genetics

350.0

CpG Islands

41.0

Exons/genetics

30.0

Protein p16/*physiology

333.0

Cell Cycle Proteins/*genetics

53.0

Genes, p53/*genetics

51.0

Heterozygote

60.0

Introns

30.0

*Polymorphism, Single Nucleotide

20.0

Genetic Predisposition to Disease/*genetics

41.0

Mutation/*genetics

80.0

Blotting, Northern

40.0

Cell Differentiation

20.0

DNA, Complementary/metabolism

30.0

*Gene Expression Regulation, Neoplastic

90.0

Genes, myc/genetics

22.0

Mice

270.0

Mice, Inbred BALB C

60.0

*Protein p16

25.0

RNA, Messenger/metabolism

30.0

*Loss of Heterozygosity

71.0

Proteins/genetics

50.0

Retinoblastoma Protein/*genetics

511.0

DNA Mutational Analysis/methods

41.0

*Founder Effect

32.0

Genetic Predisposition to Disease/genetics

30.0

Heterozygote Detection

50.0

Neoplasms, Multiple Primary/*genetics

922.0

3' Untranslated Regions

21.0

5' Untranslated Regions/genetics

21.0

Alternative Splicing

30.0

Neoplasms/*genetics

31.0

Physical Chromosome Mapping

20.0

Sequence Deletion/*genetics

21.0

Sequence Homology, Amino Acid

40.0

Sequence Homology, Nucleic Acid

20.0

Disease Susceptibility

40.0

G1 Phase

41.0

Genetic Screening

70.0

Italy/epidemiology

20.0

Linkage (Genetics)

60.0

Transcription, Genetic

90.0

Age Distribution

30.0

Cell Transformation, Neoplastic/genetics

41.0

Genes, Retinoblastoma

22.0

Genes, p53

102.0

*Nuclear Proteins

120.0

Sex Distribution

20.0

Cell Transformation, Neoplastic

20.0

Protein p16/genetics/physiology

233.0

p14ARF Protein

1924.0

Genes, p16/*genetics

3170.0

Carrier Proteins/*genetics

201.0

Chromosomes, Human, Pair 1

31.0

Chromosomes, Human, Pair 9

63.0

Cyclin-Dependent Kinases/antagonists & inhibitors

22.0

Cyclins/*genetics

21.0

*Enzyme Inhibitors

37.0

Proteins/*genetics

120.0

DNA, Neoplasm/*analysis

42.0

Introns/genetics

20.0

Polymorphism, Genetic/genetics

50.0

Adenocarcinoma/etiology/*genetics

225.0

CpG Islands/*genetics

22.0

Genes, Tumor Suppressor/genetics

84.0

Neurofibroma/*genetics

213.0

Immunoenzyme Techniques

60.0

Genes, p16/genetics

836.0

RNA, Messenger/biosynthesis/genetics

30.0

*Repressor Proteins

30.0

Phosphoric Monoester Hydrolases/genetics

1317.0

Protein p53/analysis

20.0

Chromosomes, Human, Pair 10

21.0

Cyclins/genetics

32.0

Environment

22.0

Nevus/*genetics

233.0

*Point Mutation

70.0

Valine/genetics

22.0

Likelihood Functions

52.0

Sweden

41.0

English Abstract

60.0

Radiation Dosage

33.0

Ultraviolet Rays/*adverse effects

36.0

Adenocarcinoma/*genetics/pathology

22.0

Esophageal Neoplasms/*genetics/pathology

26.0

Gene Expression Profiling

20.0

Precancerous Conditions/genetics

314.0

Adenocarcinoma/*genetics

53.0

Pancreatic Neoplasms/*genetics

55.0

Proto-Oncogenes

42.0

Syndrome

40.0

Pancreatic Neoplasms/epidemiology/*genetics/therapy

2100.0

United States/epidemiology

61.0

*Gene Silencing

31.0

Neoplasm Proteins/metabolism

30.0

Protein p16/*metabolism

412.0

Necrosis

20.0

Sensitivity and Specificity

60.0

Spain

30.0

DNA, Neoplasm/genetics/metabolism

33.0

Genetic Markers

120.0

Cluster Analysis

21.0

Oligonucleotide Array Sequence Analysis/methods

22.0

Genes, Tumor Suppressor/*genetics

103.0

Gene Frequency/genetics

20.0

Genes, ras/*genetics

33.0

Chromosome Aberrations/*genetics

21.0

In Situ Hybridization, Fluorescence/methods

33.0

Inversion, Chromosome

23.0

Kidney Neoplasms/*genetics/pathology

34.0

Protein Binding

20.0

Protein-Serine-Threonine Kinases/metabolism

20.0

Astrocytoma/*genetics

36.0

Brain Neoplasms/*genetics

53.0

Transplantation, Heterologous

20.0

Magnetic Resonance Imaging

20.0

Protein p16/genetics/metabolism

415.0

Protein p53/genetics/metabolism

22.0

Tomography, X-Ray Computed

20.0

Dysplastic Nevus Syndrome/genetics

375.0

Germ-Line Mutation/genetics

57.0

Cell Division/radiation effects

24.0

Cell Line

40.0

Enzyme Induction

30.0

Carcinoma, Squamous Cell/*genetics

74.0

Genes, Suppressor

26.0

Mouth Neoplasms/*genetics

24.0

Gene Library

20.0

*Alleles

50.0

*Carrier Proteins

20.0

*DNA-Binding Proteins

20.0

Genes, p53/genetics

62.0

Neoplasm Invasiveness

20.0

Neoplasm Recurrence, Local/genetics/pathology

220.0

Proto-Oncogene Proteins/genetics

91.0

Transcription Factors/genetics

30.0

Carrier Proteins/genetics

30.0

Genes, ras/genetics

21.0

Mice, Inbred DBA

30.0

Mice, Knockout

40.0

Protein p16

2315.0

Tumor Stem Cell Assay

31.0

Dysplastic Nevus Syndrome/*genetics

375.0

Netherlands

21.0

*Gene Amplification

30.0

Karyotyping

60.0

Disease-Free Survival

20.0

Neoplasm Proteins/genetics

30.0

Nuclear Proteins/genetics

20.0

Neoplastic Syndromes, Hereditary/*genetics

37.0

Nevus, Pigmented/genetics

350.0

Chromosomes, Human, Pair 10/genetics

33.0

Phosphoric Monoester Hydrolases/*genetics

20.0

Dysplastic Nevus Syndrome/epidemiology/*genetics

2100.0

Lung Neoplasms/genetics

23.0

Pancreatic Neoplasms/epidemiology/*genetics

342.0

Retrospective Studies

60.0

Skin Neoplasms/epidemiology/*genetics

857.0

Binding Sites

20.0

Glioblastoma/*genetics

45.0

Mutagenesis

20.0

Protein p53/*genetics

31.0

Disease Models, Animal

50.0

Immunoblotting

30.0

Protein p16/genetics/immunology/*metabolism

2100.0

Retinoblastoma Protein/genetics/metabolism

25.0

Cyclin-Dependent Kinases/*antagonists & inhibitors

32.0

Gene Expression Regulation, Neoplastic/*genetics

21.0

Hela Cells

30.0

Pilot Projects

30.0

Chromosomes, Human, Pair 11/genetics

20.0

Breast Neoplasms/*genetics

20.0

Sex Factors

20.0

Genetic Heterogeneity

41.0

Time Factors

70.0

Molecular Biology/methods

27.0

Mutation/genetics

30.0

Cyclin D1/genetics

23.0

DNA-Binding Proteins/genetics

20.0

*Genes, Retinoblastoma

21.0

Predictive Value of Tests

50.0

Transcription Factors/*genetics

20.0

Melanoma/genetics

617.0

RNA, Messenger/analysis

40.0

Skin Neoplasms/genetics

26.0

*Ultraviolet Rays

20.0

Up-Regulation

20.0

Carrier Proteins/*genetics/metabolism

41.0

Cell Line, Transformed

30.0

Cell Transformation, Neoplastic/*genetics

21.0

Clone Cells

20.0

Rats

50.0

*Chromosome Aberrations

30.0

Nucleic Acid Hybridization

50.0

Soft Tissue Neoplasms/*genetics

27.0

Chromosomes, Human, Pair 17/genetics

42.0

Mice, Nude

40.0

Nasopharyngeal Neoplasms/*genetics

29.0

Genetic Screening/*methods

21.0

In Situ Hybridization, Fluorescence/*methods

22.0

O(6)-Methylguanine-DNA Methyltransferase/genetics

27.0

Brain Neoplasms/genetics

211.0

Multiple Myeloma/*genetics

24.0

Species Specificity

20.0

Carcinoma, Small Cell/*genetics

23.0

Chromosome Banding

30.0

*Homozygote

42.0

Lung Neoplasms/*genetics

41.0

Hybrid Cells

20.0

Lod Score

50.0

Azacitidine/*analogs & derivatives/pharmacology

22.0

Hydroxamic Acids/pharmacology

21.0

Amino Acid Substitution/genetics

20.0

Receptor, Melanocortin, Type 1/*genetics

320.0

Skin Pigmentation/genetics

318.0

Penetrance

21.0

Glioma/*genetics

33.0

Glioma/*genetics/pathology

26.0

Environmental Exposure

21.0

Incidence

50.0

Risk Assessment

30.0

Prevalence

20.0

Cloning, Molecular

40.0

Cyprinodontiformes/*genetics

220.0

Phylogeny

20.0

DNA Primers

80.0

Protein Biosynthesis

40.0

Microsatellite Repeats/genetics

20.0

Polymorphism, Restriction Fragment Length

20.0

Receptors, Melanocortin

22.0

Astrocytoma/genetics

312.0

Chromosomes, Human, Pair 19

21.0

Glioblastoma/genetics

26.0

Survival Rate

50.0

Linkage (Genetics)/*genetics

31.0

Melanoma/genetics/*metabolism

212.0

Head and Neck Neoplasms/*genetics

45.0

Melanoma/etiology/*genetics/mortality

2100.0

Proto-Oncogene Proteins B-raf

34.0

Proto-Oncogene Proteins c-raf/*genetics

37.0

*Chromosome Mapping

30.0

Carcinoma/*genetics

21.0

Protein p53/genetics/*metabolism

21.0

Proto-Oncogene Proteins/genetics/*metabolism

30.0

Azacitidine/analogs & derivatives/pharmacology

28.0

DNA Modification Methylases/antagonists & inhibitors

27.0

Enzyme Inhibitors/pharmacology

30.0

Neoplasms/genetics

32.0

Melanoma/etiology/*genetics

444.0

Research Support, U.S. Gov't, Non-P.H.S.

50.0

p14ARF Protein/genetics

314.0

Chromosomes, Human, Pair 1/genetics

21.0

Chromosomes, Human, Pair 19/genetics

21.0

Neoplasm Recurrence, Local/*genetics

318.0

*Alternative Splicing

20.0

Genes, Retinoblastoma/*genetics

24.0

RNA Splicing

20.0

Mice, Inbred C57BL

20.0

Lung Neoplasms/*genetics/pathology

22.0

Crosses, Genetic

20.0

Brain Neoplasms/*genetics/*pathology

216.0

Cyclin-Dependent Kinases/analysis/*genetics

250.0

Glioblastoma/*genetics/*pathology

228.0

Purine-Nucleoside Phosphorylase/*genetics

320.0

Infant

80.0

Liver Neoplasms/*genetics

21.0

Repetitive Sequences, Nucleic Acid

20.0

Protein Kinase Inhibitors

32.0

Mesothelioma/*genetics

210.0

RNA, Messenger/genetics

30.0

RNA, Neoplasm/genetics

41.0

Carcinoma, Non-Small-Cell Lung/*genetics

22.0

Cell Division/genetics

20.0

Phosphorylation

20.0

Tumor Markers, Biological/analysis

40.0

Loss of Heterozygosity/*genetics

22.0

Carrier Proteins/genetics/*metabolism

20.0

Retinoblastoma Protein/metabolism

30.0

Genome

31.0

Sweden/epidemiology

32.0

Tumor Markers, Biological/*genetics

21.0

DNA, Neoplasm/genetics/isolation & purification

21.0

Combined Modality Therapy

20.0

Gene Expression Regulation, Neoplastic/genetics

21.0

Neoplasm Transplantation

20.0

Infant, Newborn

20.0

Oligonucleotide Array Sequence Analysis

20.0

Melanoma/*genetics/metabolism

214.0

Two-Hybrid System Techniques

20.0

Blotting, Western/methods

21.0

Immunohistochemistry/methods

20.0

Drug Combinations

20.0

Ultraviolet Rays/adverse effects

34.0

Glutathione Transferase/genetics

20.0

Jews/*genetics

21.0

DNA/metabolism

40.0

Glial Fibrillary Acidic Protein/metabolism

20.0