MeSH term
Frequency | Condition_Probility | Clinical Trials | 3 | 0.0 |
Humans | 213 | 0.0 |
Amino Acid Sequence | 46 | 0.0 |
Animals | 148 | 0.0 |
Cell Line | 16 | 0.0 |
Cerebellum/metabolism | 2 | 4.0 |
Cerebral Cortex/metabolism | 2 | 3.0 |
Cyclin-Dependent Kinases/genetics/*metabolism | 13 | 20.0 |
Mice | 56 | 0.0 |
Mice, Knockout | 8 | 0.0 |
Molecular Sequence Data | 48 | 0.0 |
Nerve Tissue Proteins/chemistry/*metabolism | 3 | 10.0 |
Phosphorylation | 76 | 0.0 |
Research Support, Non-U.S. Gov't | 144 | 0.0 |
Research Support, U.S. Gov't, P.H.S. | 74 | 0.0 |
*Signal Transduction | 3 | 0.0 |
Aged | 21 | 0.0 |
Aged, 80 and over | 17 | 0.0 |
Alzheimer Disease/enzymology/pathology | 2 | 28.0 |
Female | 27 | 0.0 |
Male | 30 | 0.0 |
Microscopy, Confocal | 5 | 0.0 |
Neurofibrillary Tangles/*enzymology/pathology | 2 | 33.0 |
tau Proteins/metabolism | 12 | 17.0 |
Blotting, Western | 18 | 0.0 |
Cell Cycle/physiology | 4 | 1.0 |
Cell Differentiation/drug effects | 5 | 0.0 |
Cyclin-Dependent Kinases/*biosynthesis | 6 | 18.0 |
Enzyme Activation/drug effects | 4 | 0.0 |
Nerve Tissue Proteins/metabolism | 11 | 5.0 |
Neurons/cytology/*metabolism | 3 | 3.0 |
Tretinoin/pharmacology | 3 | 0.0 |
Cyclins/metabolism | 6 | 1.0 |
Enzyme Inhibitors/pharmacology | 16 | 0.0 |
Genes, Dominant | 2 | 0.0 |
Hamsters | 5 | 0.0 |
Nerve Tissue Proteins/genetics/metabolism | 2 | 2.0 |
PC12 Cells | 2 | 0.0 |
Phosphorylation/drug effects | 7 | 0.0 |
*Proto-Oncogene Proteins c-bcl-2 | 2 | 0.0 |
Purines/pharmacology | 8 | 14.0 |
Rats | 34 | 0.0 |
Transfection | 25 | 0.0 |
Base Sequence | 16 | 0.0 |
Cell Division/*genetics | 2 | 3.0 |
Cloning, Molecular | 18 | 0.0 |
In Situ Hybridization | 4 | 0.0 |
*Intracellular Signaling Peptides and Proteins | 4 | 0.0 |
Open Reading Frames | 2 | 0.0 |
Rats, Sprague-Dawley | 8 | 0.0 |
Tumor Cells, Cultured | 24 | 0.0 |
Up-Regulation | 6 | 0.0 |
Models, Molecular | 8 | 0.0 |
Protein Kinases/metabolism | 4 | 0.0 |
Brain/metabolism | 6 | 0.0 |
COS Cells | 13 | 0.0 |
Comparative Study | 17 | 0.0 |
Cyclin-Dependent Kinases/metabolism | 18 | 5.0 |
*Phosphoproteins | 2 | 1.0 |
Protein Binding | 27 | 0.0 |
Cyclin-Dependent Kinases/*genetics/metabolism | 2 | 16.0 |
Immunohistochemistry | 25 | 0.0 |
Mice, Transgenic | 11 | 0.0 |
Microscopy, Electron | 2 | 0.0 |
Nerve Tissue Proteins/*genetics | 3 | 0.0 |
Antineoplastic Agents/*pharmacology | 2 | 0.0 |
Cell Cycle/drug effects | 4 | 0.0 |
Cyclin-Dependent Kinases/*antagonists & inhibitors | 8 | 5.0 |
Cyclins/physiology | 2 | 5.0 |
4-Butyrolactone/*analogs & derivatives/pharmacology | 2 | 33.0 |
Amyloid beta-Protein/*toxicity | 2 | 18.0 |
*Cell Death | 3 | 6.0 |
Enzyme Activation | 23 | 0.0 |
JNK Mitogen-Activated Protein Kinases | 3 | 0.0 |
Mitogen-Activated Protein Kinases/metabolism | 5 | 0.0 |
Neurons/*pathology | 2 | 3.0 |
Signal Transduction/*physiology | 4 | 0.0 |
p38 Mitogen-Activated Protein Kinases | 3 | 0.0 |
Cyclin-Dependent Kinases/*metabolism | 33 | 12.0 |
Enzyme Inhibitors/*metabolism | 3 | 3.0 |
Hela Cells | 9 | 0.0 |
Kinetics | 7 | 0.0 |
Neurons/cytology/*enzymology | 6 | 31.0 |
Recombinant Proteins/metabolism | 5 | 0.0 |
Immunoblotting | 9 | 0.0 |
Middle Aged | 16 | 0.0 |
Cyclin-Dependent Kinases/metabolism/*physiology | 3 | 33.0 |
Cytoskeleton/*metabolism | 3 | 2.0 |
Neurons/*physiology | 3 | 2.0 |
Neurotransmitters/physiology | 2 | 6.0 |
Cytoskeleton/metabolism/pathology | 2 | 66.0 |
Disease Models, Animal | 9 | 0.0 |
Calcium/*metabolism | 2 | 0.0 |
Calpain/*metabolism | 3 | 20.0 |
DNA/metabolism | 2 | 0.0 |
Dose-Response Relationship, Drug | 10 | 0.0 |
Mice, Inbred C57BL | 8 | 0.0 |
Neurons/cytology/metabolism | 2 | 2.0 |
Plasmids/metabolism | 4 | 0.0 |
Protein Structure, Tertiary | 9 | 0.0 |
Sequence Analysis, DNA | 4 | 0.0 |
Time Factors | 9 | 0.0 |
Transcription, Genetic | 2 | 0.0 |
Cell Movement/physiology | 2 | 0.0 |
Signal Transduction/physiology | 6 | 0.0 |
DNA Primers | 8 | 0.0 |
Evolution, Molecular | 2 | 0.0 |
Genes, Structural | 2 | 0.0 |
Polymerase Chain Reaction | 9 | 0.0 |
Species Specificity | 3 | 0.0 |
Cell Cycle | 12 | 1.0 |
Flow Cytometry | 2 | 0.0 |
Gene Deletion | 2 | 0.0 |
Glutathione Transferase/metabolism | 3 | 0.0 |
Mutagenesis, Site-Directed | 6 | 0.0 |
Mutation | 5 | 0.0 |
Precipitin Tests | 9 | 0.0 |
Protein p53/*metabolism | 2 | 0.0 |
Binding Sites | 9 | 0.0 |
Cell Line, Tumor | 12 | 0.0 |
Electrophoresis, Polyacrylamide Gel | 6 | 0.0 |
Gene Expression Regulation, Enzymologic | 3 | 0.0 |
Immunoprecipitation | 2 | 0.0 |
Nerve Tissue Proteins/*biosynthesis | 3 | 9.0 |
Neurons/*enzymology | 7 | 10.0 |
RNA, Small Interfering/metabolism | 2 | 1.0 |
Recombinant Proteins/chemistry | 2 | 0.0 |
*CDC2-CDC28 Kinases | 16 | 2.0 |
Cell Cycle/*physiology | 2 | 0.0 |
Models, Biological | 6 | 0.0 |
Protein-Serine-Threonine Kinases/metabolism | 7 | 0.0 |
Signal Transduction | 12 | 0.0 |
Crystallography, X-Ray | 3 | 0.0 |
Cyclin-Dependent Kinases/*chemistry/metabolism | 2 | 33.0 |
Nerve Tissue Proteins/*chemistry/metabolism | 2 | 11.0 |
Protein Conformation | 7 | 0.0 |
Sequence Alignment | 8 | 0.0 |
Adult | 8 | 0.0 |
Calcium/metabolism | 2 | 0.0 |
Caspases/metabolism | 3 | 0.0 |
Cell Death | 5 | 1.0 |
Neurons/metabolism/pathology | 2 | 2.0 |
Protein Processing, Post-Translational | 2 | 0.0 |
CDC2 Protein Kinase/*metabolism | 2 | 1.0 |
Cell Cycle Proteins/*metabolism | 4 | 1.0 |
Molecular Weight | 5 | 0.0 |
Peptide Fragments/metabolism | 3 | 0.0 |
Up-Regulation/genetics | 2 | 2.0 |
DNA, Complementary/genetics | 3 | 0.0 |
Gene Expression Profiling | 3 | 0.0 |
Kidney/cytology | 2 | 1.0 |
Oligonucleotide Array Sequence Analysis | 2 | 0.0 |
CDC2 Protein Kinase/metabolism | 3 | 1.0 |
Research Support, U.S. Gov't, Non-P.H.S. | 5 | 0.0 |
Neurofilament Proteins/metabolism | 4 | 7.0 |
Alzheimer Disease/etiology | 2 | 14.0 |
Cyclin-Dependent Kinases/*metabolism/physiology | 2 | 66.0 |
*Mitosis | 3 | 2.0 |
Alzheimer Disease/metabolism | 5 | 7.0 |
Ca(2+)-Calmodulin Dependent Protein Kinase/*metabolism | 3 | 1.0 |
Enzyme Inhibitors/*pharmacology | 5 | 0.0 |
Glycogen Synthase Kinase 3 | 7 | 7.0 |
Okadaic Acid/pharmacology | 3 | 3.0 |
Protein-Serine-Threonine Kinases/*metabolism | 12 | 1.0 |
Axons/physiology | 2 | 4.0 |
Brain/*enzymology | 5 | 2.0 |
Cell Membrane/metabolism | 3 | 0.0 |
Cell Movement | 2 | 0.0 |
Cell Nucleus/metabolism | 2 | 0.0 |
Microtubules/metabolism | 3 | 2.0 |
Homeostasis | 2 | 0.0 |
Tissue Distribution | 6 | 0.0 |
*Cell Cycle Proteins | 6 | 0.0 |
HL-60 Cells | 3 | 0.0 |
Cercopithecus aethiops | 3 | 0.0 |
Cyclin-Dependent Kinases/antagonists & inhibitors/metabolism | 2 | 3.0 |
Genomics | 2 | 4.0 |
Purines/*pharmacology | 3 | 17.0 |
Substrate Specificity | 5 | 0.0 |
Cytoskeletal Proteins/metabolism | 2 | 0.0 |
Nerve Tissue Proteins/*metabolism | 14 | 5.0 |
Neurons/*metabolism/pathology | 2 | 3.0 |
Apoptosis/*physiology | 2 | 0.0 |
*Apoptosis | 5 | 0.0 |
Cell Division | 5 | 0.0 |
DNA Fragmentation | 2 | 0.0 |
Protein-Serine-Threonine Kinases/*antagonists & inhibitors | 2 | 4.0 |
Cyclin-Dependent Kinases/*analysis | 3 | 15.0 |
Alzheimer Disease/*enzymology | 3 | 6.0 |
Cyclin-Dependent Kinases/chemistry/*metabolism | 2 | 25.0 |
Neurons/*cytology | 2 | 3.0 |
Brain/*metabolism | 4 | 0.0 |
Rats, Wistar | 5 | 0.0 |
Cytoskeleton/metabolism | 4 | 1.0 |
Cerebral Cortex/*cytology | 2 | 12.0 |
Cyclin-Dependent Kinases/genetics/*physiology | 2 | 22.0 |
Nerve Tissue Proteins/genetics/*physiology | 3 | 9.0 |
CHO Cells | 3 | 0.0 |
Calpain/metabolism | 2 | 8.0 |
Cytoskeletal Proteins/*metabolism | 2 | 1.0 |
Nerve Degeneration/metabolism | 2 | 25.0 |
*Trans-Activators | 2 | 0.0 |
Cells, Cultured | 19 | 0.0 |
Centrosome/metabolism | 2 | 10.0 |
Conserved Sequence | 2 | 0.0 |
Cyclin-Dependent Kinases/antagonists & inhibitors/*metabolism | 3 | 6.0 |
Microtubule-Associated Proteins/*metabolism | 2 | 1.0 |
Neurons/drug effects/metabolism/ultrastructure | 2 | 50.0 |
Organ Specificity | 2 | 0.0 |
Sequence Homology, Amino Acid | 16 | 0.0 |
Testis/metabolism | 2 | 0.0 |
Two-Hybrid System Techniques | 6 | 0.0 |
Blotting, Northern | 6 | 0.0 |
Central Nervous System/metabolism | 2 | 5.0 |
DNA Mutational Analysis | 4 | 0.0 |
DNA, Complementary/metabolism | 3 | 0.0 |
Microscopy, Fluorescence | 3 | 0.0 |
Mitogen-Activated Protein Kinase 3 | 5 | 0.0 |
Protein-Tyrosine Kinase/metabolism | 3 | 0.0 |
Recombinant Fusion Proteins/metabolism | 7 | 0.0 |
Brain Chemistry | 5 | 1.0 |
Neurons/*metabolism | 8 | 2.0 |
Silver Staining | 2 | 2.0 |
Microscopy, Immunoelectron | 3 | 0.0 |
tau Proteins/*metabolism | 14 | 30.0 |
Neurites/*metabolism | 2 | 10.0 |
Neuroblastoma | 5 | 2.0 |
Neurofilament Proteins/*metabolism | 4 | 50.0 |
RNA, Messenger/metabolism | 5 | 0.0 |
Binding, Competitive | 2 | 0.0 |
Carrier Proteins/*metabolism | 2 | 0.0 |
Macromolecular Substances | 3 | 0.0 |
Mutation/genetics | 2 | 0.0 |
Osmolar Concentration | 2 | 0.0 |
Protein Structure, Secondary | 3 | 0.0 |
Chromatography, Gel | 3 | 0.0 |
*Tumor Suppressor Proteins | 2 | 0.0 |
Amino Acid Substitution | 2 | 0.0 |
Cattle | 12 | 0.0 |
Adolescent | 2 | 0.0 |
Child | 2 | 0.0 |
Family Health | 2 | 0.0 |
Introns | 2 | 0.0 |
Peptides/chemistry | 2 | 0.0 |
Phenotype | 4 | 0.0 |
Reverse Transcriptase Polymerase Chain Reaction | 6 | 0.0 |
Cyclin-Dependent Kinases/genetics/metabolism/*physiology | 2 | 40.0 |
Signal Transduction/drug effects/physiology | 3 | 1.0 |
Biological Markers | 2 | 0.0 |
Up-Regulation/drug effects | 3 | 0.0 |
Gene Expression | 9 | 0.0 |
RNA, Messenger/genetics/metabolism | 2 | 0.0 |
Recombinant Fusion Proteins/genetics/metabolism | 6 | 0.0 |
Cyclin-Dependent Kinases/*physiology | 9 | 18.0 |
Epitopes | 4 | 0.0 |
Catalysis | 2 | 0.0 |
Enzyme Activators/pharmacology | 2 | 10.0 |
Alzheimer Disease/*pathology | 2 | 3.0 |
Neurofibrillary Tangles/*pathology | 2 | 9.0 |
*Vesicular Transport Proteins | 3 | 1.0 |
Protein-Serine-Threonine Kinases/*genetics/metabolism | 2 | 3.0 |
*Proto-Oncogene Proteins | 11 | 0.0 |
3T3 Cells | 2 | 0.0 |
Apoptosis | 3 | 0.0 |
Brain/enzymology | 3 | 1.0 |
Culture Techniques | 2 | 0.0 |
Neurofibrillary Tangles/enzymology | 2 | 50.0 |
Fluorescent Antibody Technique | 4 | 0.0 |
Cell Differentiation | 5 | 0.0 |
Cell Cycle/*drug effects | 4 | 2.0 |
Cyclin-Dependent Kinases/*antagonists & inhibitors/chemistry | 2 | 28.0 |
Cell Cycle Proteins/genetics/*metabolism | 2 | 1.0 |
Xenopus laevis | 3 | 0.0 |
Inhibitory Concentration 50 | 2 | 0.0 |
Structure-Activity Relationship | 2 | 0.0 |
Alzheimer Disease/*enzymology/pathology | 2 | 6.0 |
Dimerization | 2 | 0.0 |
Cell Death/genetics | 2 | 5.0 |
Cell Differentiation/genetics | 3 | 1.0 |
Neurodegenerative Diseases/*enzymology/genetics/physiopathology | 2 | 100.0 |
Alzheimer Disease/*metabolism | 6 | 2.0 |
Cell Size | 3 | 1.0 |
Glycogen Synthase Kinase 3/metabolism | 5 | 16.0 |
Growth Inhibitors/pharmacology | 2 | 1.0 |
Serine/metabolism | 3 | 0.0 |
Tretinoin/*pharmacology | 2 | 0.0 |
DNA-Binding Proteins/genetics/*metabolism | 2 | 0.0 |
Cyclin-Dependent Kinases/*antagonists & inhibitors/metabolism | 3 | 7.0 |
Histones/metabolism | 2 | 0.0 |
Retinoblastoma Protein/metabolism | 2 | 0.0 |
*Cyclin-Dependent Kinases | 34 | 18.0 |
*Nuclear Proteins | 2 | 0.0 |
Antibody Specificity | 4 | 0.0 |
Embryo | 2 | 0.0 |
Epitopes/analysis | 2 | 0.0 |
Peptide Mapping | 2 | 0.0 |
Swine | 3 | 0.0 |
Threonine | 2 | 3.0 |
Sequence Deletion | 3 | 0.0 |
Ca(2+)-Calmodulin Dependent Protein Kinase/metabolism | 5 | 1.0 |
Microtubules/*metabolism | 2 | 2.0 |
Protein-Serine-Threonine Kinases/*analysis | 2 | 15.0 |
Hippocampus/enzymology | 2 | 9.0 |
DNA, Complementary | 3 | 0.0 |
Mitogen-Activated Protein Kinases/*metabolism | 2 | 0.0 |
Postmortem Changes | 2 | 2.0 |
Microtubule-Associated Proteins/metabolism | 5 | 3.0 |
Phosphoproteins/*metabolism | 2 | 0.0 |
Tubulin/metabolism | 2 | 2.0 |
Glycogen Synthase Kinases | 2 | 3.0 |
tau Proteins/genetics/*metabolism | 2 | 33.0 |
Signal Transduction/genetics | 2 | 0.0 |
Gene Expression Regulation, Developmental | 2 | 0.0 |
Nerve Tissue Proteins/genetics/*metabolism | 8 | 5.0 |
Protein-Serine-Threonine Kinases/chemistry/genetics/*metabolism | 5 | 10.0 |
Mitogen-Activated Protein Kinase 1/metabolism | 2 | 0.0 |
Apoptosis/*drug effects/physiology | 2 | 1.0 |
Chromosome Mapping | 4 | 0.0 |
Pregnancy | 2 | 0.0 |
Cell Nucleus/*metabolism | 3 | 0.0 |
Cyclins/*metabolism | 3 | 1.0 |
*DNA-Binding Proteins | 2 | 0.0 |
Cyclin D1 | 4 | 3.0 |
*Drosophila Proteins | 2 | 0.0 |
Cyclins/*biosynthesis | 2 | 3.0 |
Cell Division/drug effects | 2 | 0.0 |
Proteins | 2 | 3.0 |
RNA, Messenger/genetics | 3 | 0.0 |
Cyclic AMP-Dependent Protein Kinases/metabolism | 3 | 1.0 |
tau Proteins/immunology/*metabolism | 2 | 66.0 |
Adenosine Triphosphate/metabolism | 2 | 0.0 |
Antineoplastic Agents/pharmacology | 2 | 0.0 |
Mitogen-Activated Protein Kinase 1 | 2 | 1.0 |
*Mitogen-Activated Protein Kinases | 2 | 0.0 |
Protein Kinase Inhibitors | 2 | 1.0 |
Starfish | 2 | 25.0 |
Immunoenzyme Techniques | 2 | 0.0 |
Protein Kinases/*metabolism | 3 | 0.0 |
Crosses, Genetic | 2 | 0.0 |
Mice, Neurologic Mutants | 4 | 3.0 |
Recombination, Genetic | 2 | 0.0 |
Cell Survival | 4 | 0.0 |
Glycogen Synthase Kinase 3/*metabolism | 2 | 13.0 |
Immunoblotting/methods | 2 | 4.0 |
Protein-Serine-Threonine Kinases/*immunology | 2 | 33.0 |
In Vitro | 5 | 0.0 |
Cell Culture Techniques | 2 | 0.0 |
tau Proteins/drug effects/*metabolism | 2 | 66.0 |
Anti-Bacterial Agents/pharmacology | 2 | 1.0 |
Protein-Serine-Threonine Kinases/*physiology | 2 | 1.0 |
Models, Neurological | 2 | 1.0 |
DNA Primers/genetics | 2 | 0.0 |
*Cell Aging | 2 | 3.0 |
Retinoblastoma Protein/genetics/metabolism | 2 | 5.0 |
Enzyme Inhibitors/chemistry/*pharmacology | 2 | 6.0 |
Transcription, Genetic/drug effects | 2 | 0.0 |
Virus Replication/*drug effects | 2 | 1.0 |
Gene Library | 2 | 0.0 |
Disease Progression | 3 | 0.0 |
Nerve Tissue Proteins/deficiency/genetics/*metabolism | 2 | 50.0 |
Survival Rate | 3 | 0.0 |
Nerve Tissue Proteins/*physiology | 3 | 4.0 |
Protamine Kinase/metabolism | 2 | 8.0 |
Gene Expression Regulation, Neoplastic/drug effects | 2 | 0.0 |
Protein-Serine-Threonine Kinases/chemistry/*metabolism | 2 | 5.0 |
Tissue Extracts/metabolism | 2 | 25.0 |
Cell Adhesion Molecules, Neuronal/genetics/*metabolism | 2 | 20.0 |
Extracellular Matrix Proteins/genetics/*metabolism | 2 | 15.0 |
English Abstract | 2 | 0.0 |
DNA | 2 | 0.0 |
Cyclins/genetics | 2 | 1.0 |
Cell Cycle/*genetics | 2 | 2.0 |
*Protein-Serine-Threonine Kinases | 2 | 0.0 |
Proliferating Cell Nuclear Antigen | 2 | 0.0 |
Gene Expression Regulation/physiology | 2 | 0.0 |
Neurons/enzymology | 3 | 6.0 |
Nerve Tissue Proteins/metabolism/*physiology | 2 | 14.0 |
Chick Embryo | 2 | 0.0 |
Detergents/pharmacology | 2 | 1.0 |
Green Fluorescent Proteins | 2 | 0.0 |
Luminescent Proteins/metabolism | 2 | 0.0 |
Osteosarcoma/*metabolism | 2 | 14.0 |
Mice, Mutant Strains | 2 | 0.0 |
Neurons/metabolism | 4 | 1.0 |
Enzyme Inhibitors/*pharmacology/therapeutic use | 2 | 6.0 |
Ligands | 2 | 0.0 |
Cell Movement/*physiology | 2 | 0.0 |
Serine/*metabolism | 2 | 2.0 |
Amyloid beta-Protein Precursor/*metabolism | 2 | 2.0 |
Genetic Vectors | 3 | 0.0 |
Neurons/cytology | 2 | 4.0 |
Phosphoprotein Phosphatase/metabolism | 2 | 2.0 |
